Leptin bir obese (leptin; ob/LEP) gen ürünü olup, başta adipoz doku
olmak üzere çeşitli dokulardan salgılanan bir hormondur. Leptinin enerji
metobolizmasının düzenlenmesinde önemli bir rol oynadığı ve ruminantlarda kuru
madde tüketimindeki rolü nedeniyle hayvansal üretim bakımından önemli
fonksiyonlara sahip olduğu bilinmektedir. Buna rağmen ruminant türlerinde leptin
hakkındaki bilgiler oldukça azdır ve bu hormon hakkındaki mevcut bilgilerin
çoğu insan ve kemirgenlerden elde edilmiştir. Leptin konsantrasyonu yetersiz
besleme koşullarında β-agonist enjekte edilmesi durumunda azalma
göstermektedir. Plazma leptin konsantrasyonu vücut kondüsyonu, pozitif enerji dengesi veya yeterli besleme
düzeyi ile pozitif ilişkilidir. Plazma leptin konsantrasyonu aynı zamanda tür,
ırk, gebelik, laktasyon, genotip ve çevresel koşullara bağlıdır. Son yıllarda
leptin genindeki polimorfizmlerin de plazma leptin konsantrasyonu üzerinde
etkili olduğu düşünülmektedir. Bu çalışmada yetişkin ruminatların adipoz
dokularında ve meme bezlerindeki leptin gen ekpresyonunda ve
özellikle plazma leptin konsantrasyonlarında değişikliklere etki
eden faktörler değerlendirmektedir.
Anonim. 2005. http://www.igenity.com. (Erişim : 29 Haziran 2005)
Bonnet, M., Gourdou, I., Leroux, C., Chilliard, Y., Djiane J. 2002. Leptin expression in the ovine mammary gland: Putative sequential involvement of adipose, epithelial, and myoepithelial cells during pregnancy and lactation. J. Anim. Sci. 80: 723–728.
Block, S.S., Butler, W.R., Ehrhardt, R.A., Bell, A.W., Van Amburgh, M.E., Boisclair, Y.R. 2001. Decreased concentration of plasma leptin in periparturient dairy cows is caused by negative energy balance. J. Endocrinol. 171: 339–348.
Buchanan, F. C., Fitzsimmons, C. J., Van Kessel, A. G., Thue, T.D., Winkelman-Sim, C., Schmutz, S.M. 2002. Association of a missense mutation in the bovine leptin gene with carcass fat content and leptin mRNA levels. Genet. Sel. Evol. 34: 105–116.
Buchanan, F.C., Van Kessel, A.G., Waldner, C., Christensen, D.A., Laarveld, B., Schmutz, S.M. 2003. An association between a leptin single nucleotide polymorphism and milk and protein yield. J. Dairy Sci. 86: 3164-3166.
Chilliard Y., Bonnet, M., Delavaud, C., Faulconnier, Y., Leroux, C., Djiane, J., Bocquier, F. 2001. Leptin in ruminants. Gene expression in adipose tissueand mammary gland, and regulation of plasmaconcentration. Domest. Anim. Endocrinol. 21: 271–295.
Delavoud, C., Ferlay, A., Faulconnier, Y., Bocquier, F., Kann, G., Chiliard, Y. 2002. Plasma Leptin Concentration in adult cattle: Effects of breed, adiposity, feeding level, and meal intake. J. Anim. Sci. 80: 1317-1328.
Housekneckt, K.L., Portocarreo, C.P., Ji, S., Lemenager, R., Spurlock, M.E. 2000. Growth Hormone regulates leptin gene expression in bovine adipose tissue: correlation with adipose IGF-1 expression. J. Endocrinol. 164: 51-57.
Garcia, M. R., Amstalden, M., Williams, S.W., Stanko, R.L., Morrison, C.D., Keisler, D.H., Nizielski, S.E., Williams, G. L. 2002. Serum leptin and its adipose gene expression during pubertal development, the estrous cycle, and different seasons in cattle. J. Anim. Sci. 80: 2158–2167.
Feuermann, Y., Mabjeesh, S.J., Shamay, A. 2004. Leptin affects prolactin action on milk protein and fat synthesis in the bovine mammary gland. J. Dairy Sci. 87: 2941–2946.
Ingvartsen K.L., Boisclair, Y.R. 2001. Leptin and the regulation of food intake, energy homeostasis and immunity with special focus on periparturient ruminants. Domest. Anim. Endocrinol. 21: 215-250.
Liefers, S.C., Veerkamp, R. F., Pas, M.F.W., Delavaud, C., Chilliard, Y., Lende, T. 2003a. Leptin concentrations in relation to energy balance, milk yield, intake, live weight, and estrus in dairy cows. J. Dairy Sci. 86: 799–807.
Liefers, S. C., te Pas, M. F. W, Veerkamp, R. F., Chilliard, Y., Delavaud, C., Gerritsen, R., van der Lende, T. 2003b. Association of leptin gene polymorphisms with serum leptin concentration in dairy cows. Mamm. Genome 14: 657–663.
Liefers, S.C., Veerkamp, R.F., Te Pas, M.F., Chilliard, Y., Van der Lende, T. 2005. Genetics and physiology of leptin in periparturient dairy cows. Domest. Anim. Endocrinol. 29: 227–238.
Mann, G.E., Mann, S.J., Blanhe, D., Webb, R. 2005. Metabolic variables and plasma leptin concentrations in dairy cows exhibiting reproductive cycle abnormalities identified through milk progesterone monitoring during the postpartum period. Anim. Reprod. Sci. 88: 191–202.
Marie, M., Findlay, P.A., Thomas, L., Adam, C.L. 2001. Daily patterns of plasma leptin in sheep: effects of photoperiod and food intake. J. Endocrinology 170: 277-286.
Nkrumah, J.D., Li, C., Yu, J., Hansen, C., Keisler, D.H, Moore, S.S. 2005. Polymorphisms in the bovine leptin promoter associated with serum leptin concentration, growth, feed intake, feeding behavior, and measures of carcass merit. J. Anim. Sci. 83: 20-28.
Reist, M. D., Erdin, D., Von Euw, K. Tschuemperlin, H., Leuenberger, C., Delavaud, Y., Chilliard, H., Hammon, M., Kuenzi, N., Blum, J. W. 2003. Concentrate Feeding strategy in lactating dairy cows:metabolic and endocrine changes with emphasis on leptin. J. Dairy Sci. 86: 1690–1706.
Silva, L.F., VandeHaar, M.J., Weber Nielsen, M.S., Smith, G.W. 2002. Evidence for a local effect of leptin in bovine mammary gland. J. Dairy Sci. 85(12): 3277-3286.
Tunçbilek, E. 2005. Obesite genetik bir hastalık mıdır? Çocuk Sağlığı Hast. Derg. 48: 101-108.
Wangensteen, T., Undlien, D., Tonstad, S. 2005. Lars Retterstøl Genetiske årsaker til fedme. Tidsskr. Nor. Lægeforen nr.125: 3090–3093.
Anonim. 2005. http://www.igenity.com. (Erişim : 29 Haziran 2005)
Bonnet, M., Gourdou, I., Leroux, C., Chilliard, Y., Djiane J. 2002. Leptin expression in the ovine mammary gland: Putative sequential involvement of adipose, epithelial, and myoepithelial cells during pregnancy and lactation. J. Anim. Sci. 80: 723–728.
Block, S.S., Butler, W.R., Ehrhardt, R.A., Bell, A.W., Van Amburgh, M.E., Boisclair, Y.R. 2001. Decreased concentration of plasma leptin in periparturient dairy cows is caused by negative energy balance. J. Endocrinol. 171: 339–348.
Buchanan, F. C., Fitzsimmons, C. J., Van Kessel, A. G., Thue, T.D., Winkelman-Sim, C., Schmutz, S.M. 2002. Association of a missense mutation in the bovine leptin gene with carcass fat content and leptin mRNA levels. Genet. Sel. Evol. 34: 105–116.
Buchanan, F.C., Van Kessel, A.G., Waldner, C., Christensen, D.A., Laarveld, B., Schmutz, S.M. 2003. An association between a leptin single nucleotide polymorphism and milk and protein yield. J. Dairy Sci. 86: 3164-3166.
Chilliard Y., Bonnet, M., Delavaud, C., Faulconnier, Y., Leroux, C., Djiane, J., Bocquier, F. 2001. Leptin in ruminants. Gene expression in adipose tissueand mammary gland, and regulation of plasmaconcentration. Domest. Anim. Endocrinol. 21: 271–295.
Delavoud, C., Ferlay, A., Faulconnier, Y., Bocquier, F., Kann, G., Chiliard, Y. 2002. Plasma Leptin Concentration in adult cattle: Effects of breed, adiposity, feeding level, and meal intake. J. Anim. Sci. 80: 1317-1328.
Housekneckt, K.L., Portocarreo, C.P., Ji, S., Lemenager, R., Spurlock, M.E. 2000. Growth Hormone regulates leptin gene expression in bovine adipose tissue: correlation with adipose IGF-1 expression. J. Endocrinol. 164: 51-57.
Garcia, M. R., Amstalden, M., Williams, S.W., Stanko, R.L., Morrison, C.D., Keisler, D.H., Nizielski, S.E., Williams, G. L. 2002. Serum leptin and its adipose gene expression during pubertal development, the estrous cycle, and different seasons in cattle. J. Anim. Sci. 80: 2158–2167.
Feuermann, Y., Mabjeesh, S.J., Shamay, A. 2004. Leptin affects prolactin action on milk protein and fat synthesis in the bovine mammary gland. J. Dairy Sci. 87: 2941–2946.
Ingvartsen K.L., Boisclair, Y.R. 2001. Leptin and the regulation of food intake, energy homeostasis and immunity with special focus on periparturient ruminants. Domest. Anim. Endocrinol. 21: 215-250.
Liefers, S.C., Veerkamp, R. F., Pas, M.F.W., Delavaud, C., Chilliard, Y., Lende, T. 2003a. Leptin concentrations in relation to energy balance, milk yield, intake, live weight, and estrus in dairy cows. J. Dairy Sci. 86: 799–807.
Liefers, S. C., te Pas, M. F. W, Veerkamp, R. F., Chilliard, Y., Delavaud, C., Gerritsen, R., van der Lende, T. 2003b. Association of leptin gene polymorphisms with serum leptin concentration in dairy cows. Mamm. Genome 14: 657–663.
Liefers, S.C., Veerkamp, R.F., Te Pas, M.F., Chilliard, Y., Van der Lende, T. 2005. Genetics and physiology of leptin in periparturient dairy cows. Domest. Anim. Endocrinol. 29: 227–238.
Mann, G.E., Mann, S.J., Blanhe, D., Webb, R. 2005. Metabolic variables and plasma leptin concentrations in dairy cows exhibiting reproductive cycle abnormalities identified through milk progesterone monitoring during the postpartum period. Anim. Reprod. Sci. 88: 191–202.
Marie, M., Findlay, P.A., Thomas, L., Adam, C.L. 2001. Daily patterns of plasma leptin in sheep: effects of photoperiod and food intake. J. Endocrinology 170: 277-286.
Nkrumah, J.D., Li, C., Yu, J., Hansen, C., Keisler, D.H, Moore, S.S. 2005. Polymorphisms in the bovine leptin promoter associated with serum leptin concentration, growth, feed intake, feeding behavior, and measures of carcass merit. J. Anim. Sci. 83: 20-28.
Reist, M. D., Erdin, D., Von Euw, K. Tschuemperlin, H., Leuenberger, C., Delavaud, Y., Chilliard, H., Hammon, M., Kuenzi, N., Blum, J. W. 2003. Concentrate Feeding strategy in lactating dairy cows:metabolic and endocrine changes with emphasis on leptin. J. Dairy Sci. 86: 1690–1706.
Silva, L.F., VandeHaar, M.J., Weber Nielsen, M.S., Smith, G.W. 2002. Evidence for a local effect of leptin in bovine mammary gland. J. Dairy Sci. 85(12): 3277-3286.
Tunçbilek, E. 2005. Obesite genetik bir hastalık mıdır? Çocuk Sağlığı Hast. Derg. 48: 101-108.
Wangensteen, T., Undlien, D., Tonstad, S. 2005. Lars Retterstøl Genetiske årsaker til fedme. Tidsskr. Nor. Lægeforen nr.125: 3090–3093.
Öner, Y., & Canbolat, Ö. (2014). Süt İneklerinde Leptin Düzeyine Etki Eden Bazı Faktörler. Hayvansal Üretim, 55(2), 43-48. https://doi.org/10.29185/hayuretim.363953
Creative Commons License Journal of Animal Production is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.