Üremide Metabolizma Değişiklikleri

Year 2011, Volume: 08 Issue: 1, 36 - 41, 30.06.2011

Feray Gökdoğan

Abstract

Üremi, böbrek fonksiyonlarında ilerleyici bozulma sonucunda

sıvı-elektrolit, hormon dengesizlikleri ve metabolik

anormallikler gelişen klinik bir sendromdur. Böbreklerde yaşamsal

bazı metabolik düzenleyicilerin (eritropoetin, aktif D

vitamini vb) sentezinin bozulması da bu değişikliklere önemli

katı› sağlar. Diyaliz öncesi ve diyaliz tedavisi sırasında

tüm bu faktörler atheroskleroz gelişlimi, kardiyovasküler hastalı

k, malnütrisyon, anemi, renal osteodistrofi, hiperparatiroidizm

vb. çok ciddi komplikasyonlar›n yanı sıra, hastaların

yaşam kalitesini ve prognozu önemli derecede etkileyen ciddi

sorunlara yol açar. Böbrek hastalıkları erken dönemde tanımlanır

 ve komplikasyonlar erken dönemde tedavi edilirse,

hastalığın seyri iyileştirilebilir ve maliyeti azaltılabilir.

Keywords

Üremi, Metabolik değişiklikler, Komplikasyonlar

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