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Yaşlı Hemodiyaliz Hastalarında Mortalite Düzeyi ve Bakım/ Mortality Rate and Care in Elderly Hemodialysis Patients

Year 2025, Volume: 20 Issue: 1, 61 - 70, 31.01.2025

Abstract

The mortality rate among elderly individuals undergoing hemodialysis is unacceptably high compared to the general population. The reasons behind the increased risk of death in elderly hemodialysis patients are highly complex. There is a lack of clear consensus on how best to manage end-stage renal disease in the elderly. This situation often leads to higher healthcare costs and additional clinical challenges for healthcare professionals, as the geriatric population generally requires more intensive healthcare services. Therefore, it is essential to investigate strategies focused on preventing high-risk complications, hospital admissions, and mortality rates in these patients. Understanding the distinct impact of aging on mortality is crucial for adapting effective interventions and optimizing patient care. Nurses and healthcare providers should strive to improve outcomes and enhance the quality of life for elderly individuals through personalized care plans, multidisciplinary collaboration, patient education, and ongoing research. Given the complex nature of aging and the care process, it is particularly important to examine the mortality risk specific to hemodialysis in this population. This review explores the nature of aging, the causes of mortality in elderly individuals receiving hemodialysis treatment, and the details of care strategies.

References

  • Canaud B, Tong L, Tentori F, Akiba T, Karaboyas A, Gillespie B, et al. Clinical practices and outcomes in elderly hemodialysis patients: results from the Dialysis Outcomes and Practice Patterns Study (DOPPS). Clin J Am Soc Nefrol 2011;6(7):1651-62.doi: 10.2215/CJN.03530410.
  • Sladoje-Martinovic B, Mikolasevic I, Bubic I, Racki S, Orlic L. Survival of chronic hemodialysis patients over 80 years of age. Clin Interv Aging. 2014:689-96.doi: 10.2147/CIA.S58976.
  • Coric A, Resic H, Celik D, Masnic F, Ajanovic S, Prohic N, et al. Mortality in hemodialysis patients over 65 years of age. Mater Sociomed. 2015;27(2):91.doi: 10.5455/msm.2015.27.91-94.
  • Mailloux LU, Bellucci AG, Wilkes BM, Napolitano B, Mossey RT, Lesser M, et al. Mortality in dialysis patients: analysis of the causes of death. Am J Kidney Dis. 1991;18(3):326-35.doi: 10.1016/s0272-6386(12)80091-6.
  • Chisavu L, Mihaescu A, Bob F, Motofelea A, Schiller O, Marc L, et al. Trends in mortality and comorbidities in hemodialysis patients between 2012 and 2017 in an East-European Country: a retrospective study. International Int Urol Nephrol. 2023;55(10):2579-87.doi: 10.1007/s11255-023-03549-6.
  • Dobričić M, Pakić V, Pejović V, Kuzmanović A, Milić M, Marinković J, et al. Factors influencing mortality in prevalent hemodialysis patients with different types of heart failure-a single-center experience. Srp Arh Celok Lek. 2024(00):65-.doi: 10.2298/SARH230921065D.
  • Goungounga J, Ren L, Adoli LK, Charvat H, Giorgi R, Vigneau C, et al. # 1778 Effects of comorbidities, social deprivation and sex on the excess mortality of French ESKD patients on dialysis. Nephrol Dial Transplant. 2024;39(Supplement_1):gfae069-0168-1778.doi: 10.1093/ndt/gfae069.168.
  • Hiyamuta H, Yamada S, Taniguchi M, Nakano T, Tsuruya K, Kitazono T. Causes of death in patients undergoing maintenance hemodialysis in Japan: 10-year outcomes of the Q-Cohort Study. Clin Exp Nephrol 2021;25(10):1121-30.doi: 10.1007/s10157-021-02089-6.
  • Nguyen B, Fukuuchi F. Survival rates and causes of death in Vietnamese chronic hemodialysis patients. RRT 2017;3( ):1-10.doi: 10.1186/s41100-017-0099-6.
  • Dodig S, Čepelak I, Pavić I. Hallmarks of senescence and aging. Biochem Med (Zagreb). 2019;29(3):483-97.doi: 10.11613/BM.2019.030501.
  • Chalise HN. Aging: basic concept. Am J Biomed Sci & Res. 2019;1(1):8-10.doi: 10.34297/AJBSR.2019.01.000503.
  • Hodgson R, Kennedy BK, Masliah E, Scearce-Levie K, Tate B, Venkateswaran A, et al. Aging: therapeutics for a healthy future. Neurosci Biobehav Rev. 2020;108:453-8.doi: 10.1016/j.neubiorev.2019.11.021.
  • Charan GS, Kaur A, Kaur K, Kaur N. Psychosocial Problems in Community-dwelling Older Adults: A Cross-sectional Study. Ann Afr Med. 2024;23(2):140-8.doi: 10.4103/aam.aam_139_23.
  • Schneider RH, Irigaray TQ. O envelhecimento na atualidade: aspectos cronológicos, biológicos, psicológicos e sociais. Estud Psicol (Campinas). 2008;25:585-93.doi: 10.1590/S0103-166X2008000400013.
  • un.org. [Internet]. United Nations Department of Economic and Social Affairs Population Division; 2020 [cited 2024 August 20]. Available from: https://www.un.org/development/desa/pd/sites/www.un.org.development.desa.pd/files/undesa_pd-2020_world_population_ageing_highlights.pdf.
  • unfpa.org. [Internet]. UNFPA 2024. Ageing; 2024 [cited 2024 August 20]. Available from: https://hemodiyaliz.unfpa.org/ageing.
  • tuik.gov. [Internet]. TÜİK Veri Portalı İstatistiklerle Yaşlılar; 2023 [cited 2024 August 20]. Available from: https://data.tuik.gov.tr/Bulten/Index?p=Istatistiklerle-Yaslilar-2023-53710.
  • Chmielewski P, Strzelec B, Borysławski K, Chmielowiec K, Chmielowiec J, Dąbrowski P. Effects of aging on the function of the urinary system: longitudinal changes with age in selected urine parameters in a hospitalized population of older adults. Anthropol Review. 2016;79(3):331-45.doi:10.1515/anre-2016-0024.
  • Kim B, Park CI, Hong YA, Yoon HE, Kim YK, Kim H, et al. Mortality in patients receiving renal replacement therapy in South Korea. Kidney Res Clin Pract.doi: 10.23876/j.krcp.24.035.
  • Fedeli U, Pierobon S, Grande E, Nordio M. Trends in chronic kidney disease-related mortality before and during the pandemic in Northeastern Italy. J Nephrol. 2024:1-3.doi: 10.1007/s40620-024-02020-8.
  • Tuğcu M, Kasapoğlu U, Şahin G, Apaydın S. The factors affecting survival in geriatric hemodialysis patients. Int J Nephrol. 2018;2018(1):5769762.doi:10.1155/2018/5769762.
  • Erdoğmuş Ş, Kaymakamtorunları F. Factors Associated with Mortality in Maintenance Hemodialysis Patients: A Single-Center Data from East Anatolian Region of Turkey. J Ankara Üniv Fac Med. 2020;73(3).doi: 10.4274/atfm.galenos.2020.68552.
  • Hamczyk MR, Nevado RM, Barettino A, Fuster V, Andrés V. Biological versus chronological aging: JACC focus seminar. J Am Coll Cardiol. 2020;75(8):919-30.doi: 10.1016/j.jacc.2019.11.062.
  • Ciumărnean L, Milaciu MV, Negrean V, Orășan OH, Vesa SC, Sălăgean O, et al. Cardiovascular risk factors and physical activity for the prevention of cardiovascular diseases in the elderly. Int J Environ Res Public Health. 2021;19(1):207.doi: 10.3390/ijerph19010207.
  • Oliva JS, Roa LM, Lara A, Garrido S, Salgueira M, Palma A, et al. Survival and factors predicting mortality in hemodialysis patients over 75 years old. J Nephrol. 2013;26(1):129-35.doi: 10.5301/jn.5000117.
  • Sharma G, Goodwin J. Effect of aging on respiratory system physiology and immunology. Clin Interv Aging. 2006;1(3):253-60.doi: 10.2147/ciia.2006.1.3.253.
  • Nikolich-Žugich J. The twilight of immunity: emerging concepts in aging of the immune system. Nat Immunol. 2018;19(1):10-9.doi: 10.1038/s41590-017-0006-x.
  • Kawasaki S, Aoki N, Kikuchi H, Nakayama H, Saito N, Shimada H, et al. Clinical and microbiological evaluation of hemodialysis-associated pneumonia (HDAP): should HDAP be included in healthcare-associated pneumonia? J Infect Chemother. 2011;17(5):640-5.doi: 10.1007/s10156-011-0228-z.
  • Daratha KB, Short RA, Corbett CF, Ring ME, Alicic R, Choka R, et al. Risks of subsequent hospitalization and death in patients with kidney disease. Clin J Am Soc Nephrol. 2012;7(3):409-16.doi: 10.2215/CJN.05070511.
  • Cruz-Jentoft AJ, Kiesswetter E, Drey M, Sieber CC. Nutrition, frailty, and sarcopenia. Aging Clin Exp Res. 2017;29:43-8.doi: 10.1007/s40520-016-0709-0.
  • Donato B, Almeida R, Raimundo M, Velho S, Primitivo A, Correia F, et al. Myosteatosis: an underrecognized risk factor for mortality in non-dialysis chronic kidney disease patients. J Nephrol. 2024:1-9.doi: 10.1007/s40620-024-02042-2. Nefroloji Hemşireliği Dergisi 2025; 20(1): 61-70
  • Dumic I, Nordin T, Jecmenica M, Stojkovic Lalosevic M, Milosavljevic T, Milovanovic T. Gastrointestinal tract disorders in older age. Can J Gastroenterol Hepatol. 2019;2019(1):6757524.doi: 10.1155/2019/6757524.
  • Luo J-C, Leu H-B, Huang K-W, Huang C-C, Hou M-C, Lin H-C, et al. Incidence of bleeding from gastroduodenal ulcers in patients with end-stage renal disease receiving hemodialysis. CMAJ. 2011;183(18):E1345-E51.doi: 10.1503/cmaj.110299.
  • Karabey T, Karagözoğlu Ş. Hemodiyaliz Sürecinde Semptom Yönetimi ve Hemşirelik Bakımı. J TOGU Heal Sci [Internet]. 2021[cited 2024 Aug 19];1(1):21-9.Available from: https://dergipark.org.tr/en/pub/togusagbilderg/issue/65817/1027002.
  • Koştu N, Ok D. Kateter Yeri Enfeksiyonu Gelişen Hemodiyaliz Hastasının Fonksiyonel Sağlık Örüntülerine Göre Hemşirelik Bakımı: Olgu Sunumu. Hemşirelik Bilimi Dergisi[Internet]. 2021[cited 2024 Aug 19];4(2):106-13.Available from: https://dergipark.org.tr/tr/pub/hbd/issue/64902/956533.
  • Ak ÖB, Gençtürk N, Şen E. Türk toplumunun ulusal kanser tarama programları konusunda bilgi ve davranış düzeylerinin belirlenmesi: Kesitsel bir çalışma. Sağlık ve Yaşam Bilimleri Dergisi. 2024;6(2):77-86.doi:10.33308/2687248X.202462338.
  • Aydemir T, Çetin Ş. Kronik hastalıklar ve psikososyal bakım. JAMER [Internet]. 2019[cited 2024 Aug 18];4(3):109-15.Available from: https://dergipark.org.tr/tr/pub/jamer/issue/50387/642116.
  • Topbaş E, Bingöl G. Psikososyal boyutu ile diyaliz tedavisi ve uyum sürecine yönelik hemşirelik girişimleri. Nefro Hem Dergi [Internet]. 2017[cited 2024 Aug 18];12(1):36-42.Available from: https://dergipark.org.tr/tr/download/article-file/363922.

Yaşlı Hemodiyaliz Hastalarında Mortalite Düzeyi ve Bakım/ Mortality Rate and Care in Elderly Hemodialysis Patients

Year 2025, Volume: 20 Issue: 1, 61 - 70, 31.01.2025

Abstract

Hemodiyaliz tedavisi gören yaşlı bireylerde ölüm oranı genel popülasyona kıyasla kabul edilemez derecede yüksektir. Yaşlı hemodiyaliz hastalarında ölüm riskinin artmasının nedenleri oldukça karmaşıktır. Yaşlılarda son dönem böbrek yetmezliğinin en iyi şekilde nasıl yönetileceğine dair net görüşler bulunmamaktadır. Bu durum, geriatrik popülasyonun genellikle daha zorlu sağlık bakım ihtiyaçlarını karşılaması için daha yüksek sağlık bakım maliyetlerine ve sağlık profesyonelleri açısından ek klinik zorluklara dönüşmektedir. Dolayısıyla bu hastalarda yüksek riskli komplikasyonlara odaklanan, hastane yatışını ve mortalite düzeyini önleme stratejilerinin incelenmesine ihtiyaç vardır. Yaşlılığın mortalite üzerindeki farklı etkisinin anlaşılması, etkili müdahalelerin uyarlanması ve hasta bakımının optimize edilmesi için önemlidir. Kişiselleştirilmiş bakım planları, multidisipliner iş birliği, hasta eğitimi ve bu konuda yapılan araştırmalarla hemşireler ve sağlık hizmeti sağlayıcıları yaşlı bireylerin sonuçlarını iyileştirmek ve yaşam kalitesini artırmak için çabalamalıdır. Yaşlılığın ve bakım sürecinin karmaşık doğası sebebiyle, bu popülasyonda hemodiyalize özgü mortalite riskini incelemek ayrıca önemlidir. Bu derlemede; yaşlılığın doğası, hemodiyaliz tedavisi alan yaşlı bireylerde mortalite sebepleri ve bakım stratejilerine ilişkin ayrıntılar incelenmiştir.

References

  • Canaud B, Tong L, Tentori F, Akiba T, Karaboyas A, Gillespie B, et al. Clinical practices and outcomes in elderly hemodialysis patients: results from the Dialysis Outcomes and Practice Patterns Study (DOPPS). Clin J Am Soc Nefrol 2011;6(7):1651-62.doi: 10.2215/CJN.03530410.
  • Sladoje-Martinovic B, Mikolasevic I, Bubic I, Racki S, Orlic L. Survival of chronic hemodialysis patients over 80 years of age. Clin Interv Aging. 2014:689-96.doi: 10.2147/CIA.S58976.
  • Coric A, Resic H, Celik D, Masnic F, Ajanovic S, Prohic N, et al. Mortality in hemodialysis patients over 65 years of age. Mater Sociomed. 2015;27(2):91.doi: 10.5455/msm.2015.27.91-94.
  • Mailloux LU, Bellucci AG, Wilkes BM, Napolitano B, Mossey RT, Lesser M, et al. Mortality in dialysis patients: analysis of the causes of death. Am J Kidney Dis. 1991;18(3):326-35.doi: 10.1016/s0272-6386(12)80091-6.
  • Chisavu L, Mihaescu A, Bob F, Motofelea A, Schiller O, Marc L, et al. Trends in mortality and comorbidities in hemodialysis patients between 2012 and 2017 in an East-European Country: a retrospective study. International Int Urol Nephrol. 2023;55(10):2579-87.doi: 10.1007/s11255-023-03549-6.
  • Dobričić M, Pakić V, Pejović V, Kuzmanović A, Milić M, Marinković J, et al. Factors influencing mortality in prevalent hemodialysis patients with different types of heart failure-a single-center experience. Srp Arh Celok Lek. 2024(00):65-.doi: 10.2298/SARH230921065D.
  • Goungounga J, Ren L, Adoli LK, Charvat H, Giorgi R, Vigneau C, et al. # 1778 Effects of comorbidities, social deprivation and sex on the excess mortality of French ESKD patients on dialysis. Nephrol Dial Transplant. 2024;39(Supplement_1):gfae069-0168-1778.doi: 10.1093/ndt/gfae069.168.
  • Hiyamuta H, Yamada S, Taniguchi M, Nakano T, Tsuruya K, Kitazono T. Causes of death in patients undergoing maintenance hemodialysis in Japan: 10-year outcomes of the Q-Cohort Study. Clin Exp Nephrol 2021;25(10):1121-30.doi: 10.1007/s10157-021-02089-6.
  • Nguyen B, Fukuuchi F. Survival rates and causes of death in Vietnamese chronic hemodialysis patients. RRT 2017;3( ):1-10.doi: 10.1186/s41100-017-0099-6.
  • Dodig S, Čepelak I, Pavić I. Hallmarks of senescence and aging. Biochem Med (Zagreb). 2019;29(3):483-97.doi: 10.11613/BM.2019.030501.
  • Chalise HN. Aging: basic concept. Am J Biomed Sci & Res. 2019;1(1):8-10.doi: 10.34297/AJBSR.2019.01.000503.
  • Hodgson R, Kennedy BK, Masliah E, Scearce-Levie K, Tate B, Venkateswaran A, et al. Aging: therapeutics for a healthy future. Neurosci Biobehav Rev. 2020;108:453-8.doi: 10.1016/j.neubiorev.2019.11.021.
  • Charan GS, Kaur A, Kaur K, Kaur N. Psychosocial Problems in Community-dwelling Older Adults: A Cross-sectional Study. Ann Afr Med. 2024;23(2):140-8.doi: 10.4103/aam.aam_139_23.
  • Schneider RH, Irigaray TQ. O envelhecimento na atualidade: aspectos cronológicos, biológicos, psicológicos e sociais. Estud Psicol (Campinas). 2008;25:585-93.doi: 10.1590/S0103-166X2008000400013.
  • un.org. [Internet]. United Nations Department of Economic and Social Affairs Population Division; 2020 [cited 2024 August 20]. Available from: https://www.un.org/development/desa/pd/sites/www.un.org.development.desa.pd/files/undesa_pd-2020_world_population_ageing_highlights.pdf.
  • unfpa.org. [Internet]. UNFPA 2024. Ageing; 2024 [cited 2024 August 20]. Available from: https://hemodiyaliz.unfpa.org/ageing.
  • tuik.gov. [Internet]. TÜİK Veri Portalı İstatistiklerle Yaşlılar; 2023 [cited 2024 August 20]. Available from: https://data.tuik.gov.tr/Bulten/Index?p=Istatistiklerle-Yaslilar-2023-53710.
  • Chmielewski P, Strzelec B, Borysławski K, Chmielowiec K, Chmielowiec J, Dąbrowski P. Effects of aging on the function of the urinary system: longitudinal changes with age in selected urine parameters in a hospitalized population of older adults. Anthropol Review. 2016;79(3):331-45.doi:10.1515/anre-2016-0024.
  • Kim B, Park CI, Hong YA, Yoon HE, Kim YK, Kim H, et al. Mortality in patients receiving renal replacement therapy in South Korea. Kidney Res Clin Pract.doi: 10.23876/j.krcp.24.035.
  • Fedeli U, Pierobon S, Grande E, Nordio M. Trends in chronic kidney disease-related mortality before and during the pandemic in Northeastern Italy. J Nephrol. 2024:1-3.doi: 10.1007/s40620-024-02020-8.
  • Tuğcu M, Kasapoğlu U, Şahin G, Apaydın S. The factors affecting survival in geriatric hemodialysis patients. Int J Nephrol. 2018;2018(1):5769762.doi:10.1155/2018/5769762.
  • Erdoğmuş Ş, Kaymakamtorunları F. Factors Associated with Mortality in Maintenance Hemodialysis Patients: A Single-Center Data from East Anatolian Region of Turkey. J Ankara Üniv Fac Med. 2020;73(3).doi: 10.4274/atfm.galenos.2020.68552.
  • Hamczyk MR, Nevado RM, Barettino A, Fuster V, Andrés V. Biological versus chronological aging: JACC focus seminar. J Am Coll Cardiol. 2020;75(8):919-30.doi: 10.1016/j.jacc.2019.11.062.
  • Ciumărnean L, Milaciu MV, Negrean V, Orășan OH, Vesa SC, Sălăgean O, et al. Cardiovascular risk factors and physical activity for the prevention of cardiovascular diseases in the elderly. Int J Environ Res Public Health. 2021;19(1):207.doi: 10.3390/ijerph19010207.
  • Oliva JS, Roa LM, Lara A, Garrido S, Salgueira M, Palma A, et al. Survival and factors predicting mortality in hemodialysis patients over 75 years old. J Nephrol. 2013;26(1):129-35.doi: 10.5301/jn.5000117.
  • Sharma G, Goodwin J. Effect of aging on respiratory system physiology and immunology. Clin Interv Aging. 2006;1(3):253-60.doi: 10.2147/ciia.2006.1.3.253.
  • Nikolich-Žugich J. The twilight of immunity: emerging concepts in aging of the immune system. Nat Immunol. 2018;19(1):10-9.doi: 10.1038/s41590-017-0006-x.
  • Kawasaki S, Aoki N, Kikuchi H, Nakayama H, Saito N, Shimada H, et al. Clinical and microbiological evaluation of hemodialysis-associated pneumonia (HDAP): should HDAP be included in healthcare-associated pneumonia? J Infect Chemother. 2011;17(5):640-5.doi: 10.1007/s10156-011-0228-z.
  • Daratha KB, Short RA, Corbett CF, Ring ME, Alicic R, Choka R, et al. Risks of subsequent hospitalization and death in patients with kidney disease. Clin J Am Soc Nephrol. 2012;7(3):409-16.doi: 10.2215/CJN.05070511.
  • Cruz-Jentoft AJ, Kiesswetter E, Drey M, Sieber CC. Nutrition, frailty, and sarcopenia. Aging Clin Exp Res. 2017;29:43-8.doi: 10.1007/s40520-016-0709-0.
  • Donato B, Almeida R, Raimundo M, Velho S, Primitivo A, Correia F, et al. Myosteatosis: an underrecognized risk factor for mortality in non-dialysis chronic kidney disease patients. J Nephrol. 2024:1-9.doi: 10.1007/s40620-024-02042-2. Nefroloji Hemşireliği Dergisi 2025; 20(1): 61-70
  • Dumic I, Nordin T, Jecmenica M, Stojkovic Lalosevic M, Milosavljevic T, Milovanovic T. Gastrointestinal tract disorders in older age. Can J Gastroenterol Hepatol. 2019;2019(1):6757524.doi: 10.1155/2019/6757524.
  • Luo J-C, Leu H-B, Huang K-W, Huang C-C, Hou M-C, Lin H-C, et al. Incidence of bleeding from gastroduodenal ulcers in patients with end-stage renal disease receiving hemodialysis. CMAJ. 2011;183(18):E1345-E51.doi: 10.1503/cmaj.110299.
  • Karabey T, Karagözoğlu Ş. Hemodiyaliz Sürecinde Semptom Yönetimi ve Hemşirelik Bakımı. J TOGU Heal Sci [Internet]. 2021[cited 2024 Aug 19];1(1):21-9.Available from: https://dergipark.org.tr/en/pub/togusagbilderg/issue/65817/1027002.
  • Koştu N, Ok D. Kateter Yeri Enfeksiyonu Gelişen Hemodiyaliz Hastasının Fonksiyonel Sağlık Örüntülerine Göre Hemşirelik Bakımı: Olgu Sunumu. Hemşirelik Bilimi Dergisi[Internet]. 2021[cited 2024 Aug 19];4(2):106-13.Available from: https://dergipark.org.tr/tr/pub/hbd/issue/64902/956533.
  • Ak ÖB, Gençtürk N, Şen E. Türk toplumunun ulusal kanser tarama programları konusunda bilgi ve davranış düzeylerinin belirlenmesi: Kesitsel bir çalışma. Sağlık ve Yaşam Bilimleri Dergisi. 2024;6(2):77-86.doi:10.33308/2687248X.202462338.
  • Aydemir T, Çetin Ş. Kronik hastalıklar ve psikososyal bakım. JAMER [Internet]. 2019[cited 2024 Aug 18];4(3):109-15.Available from: https://dergipark.org.tr/tr/pub/jamer/issue/50387/642116.
  • Topbaş E, Bingöl G. Psikososyal boyutu ile diyaliz tedavisi ve uyum sürecine yönelik hemşirelik girişimleri. Nefro Hem Dergi [Internet]. 2017[cited 2024 Aug 18];12(1):36-42.Available from: https://dergipark.org.tr/tr/download/article-file/363922.
There are 38 citations in total.

Details

Primary Language Turkish
Subjects ​Internal Diseases Nursing​, Nursing (Other)
Journal Section Article
Authors

Tuğba Aydemir 0000-0002-2496-5304

Publication Date January 31, 2025
Submission Date August 21, 2024
Acceptance Date October 10, 2024
Published in Issue Year 2025 Volume: 20 Issue: 1

Cite

Vancouver Aydemir T. Yaşlı Hemodiyaliz Hastalarında Mortalite Düzeyi ve Bakım/ Mortality Rate and Care in Elderly Hemodialysis Patients. JoNN. 2025;20(1):61-70.

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