Mortaliteyle Sonuçlanan Geç Başlangıçlı Warfarin Kaynaklı Cilt Nekrozu Olgusu

Year 2023, , 59 - 61, 20.02.2023

Sinem Bayrakçı , Pınar Korkmaz

https://doi.org/10.52827/hititmedj.1173309

Abstract

Warfarine bağlı cilt nekrozu, warfarin tedavisinin nadir görülen bir komplikasyonudur ve yüksek mortalite ile ilişkilidir. Burada 5,5 yıl önce atriyal fibrilasyon ve geçirilmiş mitral kapak cerrahisi nedeniyle warfarin tedavisine başlanan 53 yaşında kadın hastada ölümcül seyreden warfarine bağlı cilt nekrozu olgusu sunulmaktadır. Warfarin kullanan hastalar cilt lezyonları ile başvurduklarında warfarine bağlı cilt nekrozu açısından değerlendirilmelidir. Erken tanı, ilacın erken kesilmesi ve destek tedavisine erken başlanması hayat kurtarıcı olabilir.

Keywords

cilt nekrozu, geç başlangıçlı, warfarin

A Case Of Late-onset Warfarin Induced Skin Necrosis Resulting In Mortality

Abstract

Warfarin-induced skin necrosis is a rare complication of warfarin therapy and is associated with high mortality. Here, we present a case of warfarin-induced skin necrosis, that was fatal in a 53-year-old female patient who was started on warfarin treatment 5.5 years ago due to atrial fibrillation and previous mitral valve surgery. Patients using warfarin should be evaluated for warfarin-induced skin necrosis when they present with skin lesions. Early diagnosis, early discontinuation of the drug, early initiation of supportive treatment can be life-saving.

Keywords

late onset, skin necrosis, warfarin

References

• 1. Chan YC, Valenti D, Mansfield AO, Stansby G. Warfarin induced skin necrosis. Br J Surg. 2000;87(3):266-272.
• 2. Sternberg ML, Pettyjohn FS. Warfarin sodium-induced skin necrosis. Ann Emerg Med. 1995;26(1):94-97.
• 3. Goldberg SL, Orthner CL, Yalisove BL, Elgart ML, Kessler CM. Skin necrosis following prolonged administration of coumarin in a patient with inherited protein S deficiency. Am J Hematol. 1991;38(1):64-66.
• 4. Muniesa C, Marcoval J, Moreno A, et al. Coumarin necrosis induced by renal insufficiency. Br J Dermatol. 2004;151(2):502-504.
• 5. Kumar M, Abrina VM, Chittimireddy S. Coumadin-induced skin necrosis in a 64 year-old female despite LMWH bridging therapy. Am J Case Rep. 2012;13:157-159.
• 6. Teepe RG, Broekmans AW, Vermeer BJ, Nienhuis AM, Loeliger EA. Recurrent coumarin-induced skin necrosis in a patient with an acquired functional protein C deficiency. Arch Dermatol. 1986;122(12):1408-1412.