İn-vitro Fertilizasyon Tedavisi Alan İnfertil Kadınlarda Serum Büyüme Farklılaşma Faktörü-15 (GDF-15) Düzeyi İle Klinik Sonuçlar Arası İlişki

Year 2024, , 48 - 55, 26.02.2024

Ercan Ayaz , Ümit Görkem , Özgür Kan , Cihan Toğrul , Ülkü Şimşek , Orkun Han

https://doi.org/10.52827/hititmedj.1363447

Abstract

Amaç: Büyüme Farklılaşma Faktörü-15 (GDF-15)'in fizyolojik veya patolojik süreçlerde önemli rolu olduğu bir çok çalışmada bildirilmiştir. Güncel literatürde, GDF-15’in infertilitedeki durumunu ve tedavi sonrası sonuçlarını inceleyen bir çalışma bulunmamasından dolayı bunu araştırmayı amaçladık.
Gereç ve Yöntemler: Çalışmaya 88 infertil kadın dahil edildi ve over rezerv özelliklerine göre çalışma populasyonu üç gruba ayrıldı. Bunlar; normal over rezervi (NOR) , azalmış over rezervi (AOR) grubu, polikistik over sendromu (PKOS) grubu. Serumlarında östradiol (E2), follikül uyarıcı hormon (FSH) ve luteinize edici hormon (LH), anti-müllerian hormon (AMH) ve GDF-15 düzeyleri ölçülmüştür. Antagonist protokolü ile tedaviye alınan hastaların total oosit , mayoz II (MII) oosit, embriyo sayısı ve klinik gebelik oranları dökümente edilmiştir.
Bulgular: Serum GDF-15 konsantrasyonları dikkate alındığında her üç çalışma grubunun ortalama değerleri arasında istatistiksel yönden anlamlı bir fark bulunmamıştır. Bazal FSH ortalaması AOR grubunda PKOS grubundaki katılımcılara göre anlamlı düzeyde yüksekti. Her üç grubun serum AMH düzey ortancası istatistiksel anlamlılıkta farklı bulunmuştur. Total Oosit, MII oosit ve embriyo ortalama karşılaştırmalarında NOR grubu AOR grubuna göre ve PKOS grubu AOR grubuna göre daha yüksek değerlere sahiptir.
Sonuç: Çalışmamızda serum GDF-15 düzeyinin in-vitro fertilizasyon (İVF) tedavisi sonucunda oluşan embriyo sayıları arasında anlamlı ve güçlü bir ilişki saptanmıştır. Dolayısı ile serum GDF-15 düzeyi İVF klinik sonuçlarını öngören bir biyobelirteç olabileceği düşünülebilir.

Keywords

Büyüme Farklılaşma Faktörü-15, GDF-15, İVF, İnfertilite, Over rezervi

Ethical Statement

Hitit Üniversitesi Etik Kurulu (13.10.2021, Karar No: 493) tarafından etik onayı yapılmıştır.

Project Number

Hitit Üniversitesi Bilimsel Araştırma Projelereri Koordinatörlüğü (Proje No: TIP19001.21.008)

The Relationship Between Serum Growth Differentiation Factor-15 (GDF-15) Levels and Clinical Outcomes in Infertile Women Receiving In-vitro Fertilization Treatment

Abstract

Objective: It has been reported in many studies that Growth Differentiation Factor-15 (GDF-15) has an important role in physiological or pathological processes. As there is no study in the current scientific literature examining the status of GDF-15 in infertility and its treatment outcomes, we aimed to investigate this.
Material and methods: According to their ovarian reserve characteristics, 88 infertile women were divided into three groups: normal ovarian reserve (NOR), diminished ovarian reserve (DOR), and polycystic ovary syndrome (PCOS). Estradiol (E2), follicle-stimulating hormone (FSH), luteinizing hormone (LH), anti-mullerian hormone (AMH), and GDF-15 levels were measured in their serum. The antagonist protocol patients' total oocyte, meiosis II (MII) oocytes, embryo count, and clinical pregnancy rates were documented.
Results: In terms of serum GDF-15 concentrations, there was no statistically significant difference among the mean values of the three study groups. The mean FSH level at baseline was substantially higher in the DOR group compared to the PCOS group. The median serum AMH levels of all three groups were found to be statistically different. The antagonist protocol patients' total oocytes, meiosis II (MII) oocytes, embryo count, and clinical pregnancy rates were documented.
Conclusion: In the present study, a significant and strong correlation between serum GDF-15 level and consequent embryo number was detected. Thereby, serum GDF-15 level may be considered to be a biomarker for predicting IVF clinical outcomes.

Keywords

Keywords: Growth Differentiation Factor- 15, GDF-15, IVF, Infertility, Ovarian reserve

Project Number

Hitit Üniversitesi Bilimsel Araştırma Projelereri Koordinatörlüğü (Proje No: TIP19001.21.008)

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