Objective: Excess adiposity
has effects on various aspects of
pubertal development as the timing of pubertal initiation and hormonal parameters during puberty. We aimed to determine the effect of
BMI on peak LH (luteinizing hormone)
levels obtained by standard GnRH (Gonadotropin
Releasing Hormone) stimulation test in girls with central precicous puberty.
Materials and Methods: A total of 59 female patients who were diagnosed as
idiopathic central precicous pubertywere
included in the study. Anthropometric measurements at the time of GnRH stimulation test and basal/stimulated
gonadotropin levels were evaluated. The relationship between BMI and gonadotropins
was investigated.
Results: The mean age
of the participants was 7.11±1.01 (3.20-7.94) years. 21 cases(35
%) were overweight/obese. 67.8% (n = 40) of the cases were presented with
breast development and 64.4% (n = 38) were in stage 2, 35.6% (n = 21) were in
stage 3 puberty. There was no significant correlation between BMI SDS and
basal/peak LH levels (p=0.531, p= 0.598 for stage 2 and p=0.126, p=0.827 for stage
3 puberty respectively), peak LH
/ FSH (follicle-stimulating
hormone)ratio (p=0.408
for stage 2 and p=0.797 for stage
3 puberty) in patients
according to both puberty stages. There was not also any correlation between BMI /BMI SDS and peak LH in total study group.Basal LH, FSH, E2
and peak LH levels did not
vary among normal weight,
overweight and obese
cases.
Conclusion: Body mass index had no effect on
basal and stimulated gonadotropin levels in girls with central precicous puberty
in different stages of puberty.
Primary Language | English |
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Journal Section | Research Articles |
Authors | |
Publication Date | February 29, 2020 |
Submission Date | November 25, 2019 |
Acceptance Date | February 12, 2020 |
Published in Issue | Year 2020 Volume: 2 Issue: 1 |
Hitit Medical Journal is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License (CC BY NC).