İntrahepatik Gebelik Kolestazında Plazma Lipid Düzeylerinin Değerlendirilmesi

Year 2023, Volume: 5 Issue: 3, 190 - 194, 10.10.2023

Merve Öztürk Ağaoğlu , Zahid Ağaoğlu , Şevki Çelen

https://doi.org/10.52827/hititmedj.1321034

Abstract

Amaç: Çalışmamızın amacı, intrahepatik gebelik kolestazı tanılı gebelerde total kolesterol, trigliserid, LDL, VLDL, HDL düzeylerini araştırmak ve hastalık şiddeti ile ilişkisini incelemektir.
Gereç ve Yöntem: İntrahepatik gebelik kolestazı tanılı 40 ve benzer yaş grubunda 40 kontrol olmak üzere toplam 80 gebe prospektif olarak çalışmaya dahil edildi. Vaka ve kontrol grubu arasında lipid parametreleri karşılaştırıldı ve hastalık şiddeti ile ilişkisi analiz edildi. Doğum ağırlığı, doğumdaki gebelik haftası ve yenidoğan sonuçları incelendi.
Bulgular: İntrahepatik gebelik kolestazı tanılı grupta sağlıklı gebelere göre LDL, VLDL düzeyleri anlamlı olarak daha yüksek ve HDL düzeyleri daha düşük saptandı (p<0,05). Total kolesterol ve trigliserid seviyeleri iki grupta benzerdi. Gebelik kolestazı grubunda doğum haftası, doğum kilosu ve 1-5.dakika Apgar skorları daha düşük, yenidoğan yoğun bakıma yatış ve primer sezaryen oranları daha yüksekti (p<0,05). Korelasyon analizinde, serum LDL ile safra asiti seviyeleri arasında pozitif yönde korelasyon saptandı (r=0,349, p=0,027). LDL düzeyi, şiddetli hastalık grubunda hafif hastalık grubuyla karşılaştırıldığında anlamlı olarak yüksekti (p=0,009).
Sonuç: İntrahepatik gebelik kolestazında lipid homeostazında önemli değişiklikler meydana gelmektedir. LDL ve VLDL yüksekliği gibi anormal lipid düzeyleri gebelik kolestazı patogenezinde rol oynayabilir ve özellikle yüksek LDL kolesterol düzeyi kolestaz şiddetinin tahminine katkıda bulunabilir.

Keywords

Gebeliğin intrahepatik kolestazı, kolesterol, safra asitleri, triglseridler

Evaluation of Plasma Lipid Levels in Intrahepatic Cholestasis of Pregnancy

Abstract

Objective: To investigate the total cholesterol, triglyceride, LDL, VLDL, and HDL levels of pregnant women diagnosed with intrahepatic cholestasis of pregnancy and to examine the association with disease severity.
Material and Method: A total of 80 pregnant women, 40 of whom were diagnosed with intrahepatic cholestasis of pregnancy, and 40 age-matched controls, were prospectively enrolled in this study. Lipid levels were compared among the case and controls, and their association with disease severity was analyzed. Birth weight, birth week, and neonatal outcomes were studied.
Results: LDL and VLDL were significantly higher, and HDL levels were lower in the intrahepatic cholestasis of the pregnancy group than in the healthy pregnancies (p<0.05). Total cholesterol and triglyceride levels did not differ among the two groups. Birth weight, birth week, and 1-5-minute Apgar scores were lower, and the neonatal intensive care unit admission and the rate of primary cesarean section were higher in the group with intrahepatic cholestasis in pregnancy (p<0.05). In correlation analysis, a positive correlation was found between serum LDL and bile acids levels (r=0.349, p=0.027). LDL levels were significantly higher in severe disease than in mild disease (p=0.009)
Conclusion: There are significant changes in lipid homeostasis in intrahepatic cholestasis of pregnancy. Abnormal lipid levels, such as high LDL and VLDL levels, could have a role in the pathogenesis, and in particular high LDL levels may contribute to the prediction of disease severity.

Keywords

Bile acids, cholesterol, intrahepatic cholestasis of pregnancy, triglycerides

Supporting Institution

none

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