İnflamatuvar Barsak Hastalıklarında Laboratuvar Sonuçları ile Endoskopik Bulgular Arasındaki İlişki

Year 2024, Volume: 6 Issue: 2, 153 - 160, 30.06.2024

Mehtap Şahin , Nihat Okçu

https://doi.org/10.52827/hititmedj.1415074

Abstract

Amaç: Bu çalışmanın amacı, inflamatuvar barsak hastalığı (İBH) olan olgularda rutin laboratuvar bulguları (hemoglobin, beyaz küre, trombosit, eritrosit sedimentasyon hızı (ESH), C-reaktif protein (CRP)) ile endoskopik tutulum alanları arasındaki ilişkiyi belirlemektir.
Gereç ve Yöntem: 2009-2015 yılları arasında Ülseratif Kolit (ÜK) ve Crohn Hastalığı (CH) tanısı alan hastaların tıbbi kayıtları geriye dönük olarak incelendi. Endoskopik bulgular ile kolonoskopi sırasındaki hemoglobin, beyaz kan hücresi, trombosit, ESR ve CRP değerleri kaydedildi. Laboratuvar parametreleri ile endoskopik tutulum lokalizasyonu arasındaki ilişkiyi incelemek için multinominal lojistik regresyon modeli oluşturuldu.
Bulgular: ÜK’te; ekstensif kolit/pankolit tutulumunda distal tip kolite göre hemoglobin değerinde anlamlı derecede düşüş saptanmışken (p=0.02), sol taraf kolitiyle distal tip kolit arasında anlamlı fark saptanmamıştır. Sol taraf koliti (p=0,007) ve ekstensif kolit/pankolit (p=0.043) tutulumunda distal tip kolite göre ESH değerleri belirgin yüksek bulunmuştur. CRP değeri sadece ekstensif kolit/pankolit tutulumunda anlamlı yüksek çıkmıştır (p=0.015). CH için laboratuvar parametreleri ile tutulum yerleri arasında herhangi bir ilişki bulunamamıştır.
Sonuç: ÜK'te hemoglobin değeri, ESR ve CRP düzeyleri tutulumun yerini belirlemede yardımcı olsa da CH’de etkileri görülmemiştir. Hastaların değerlendirilmesinde bu temel laboratuvar değerlerinin yanı sıra diğer parametrelerin de dikkate alınması gerekir.

Keywords

C-reaktif protein, Crohn Hastalığı, eritrosit sedimentasyon hızı, Ülseratif kolit

The Relationship Between Endoscopic Findings and Laboratory Results in Inflammatory Bowel Diseases

Abstract

Objective: The aim of this study was to determine the relationship between routine laboratory indicators [Including hemoglobin, white blood cells, platelets, erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP)] and the extent of endoscopic involvement in individuals with inflammatory bowel disease (IBD).
Material and Method: The medical records of patients who were diagnosed with Ulcerative Colitis (UC) and Crohn’s Disease (CD) between 2009 and 2015 were retrospectively examined. Endoscopic findings and hemoglobin, white blood cell, platelet, ESR, and CRP values at the time of colonoscopy were analyzed. An exploratory multinomial regression model was created to examine the association of laboratory parameters and endoscopic involvement localization.
Results: In UC, a significant decrease in hemoglobin levels was present in cases with extensive colitis/pancolitis compared to distal type colitis (p=0.02), while no significant difference was found between left-sided colitis and distal type colitis. Elevated ESR values were notably found in left-sided colitis (p=0.007) and extensive colitis/ pancolitis (p=0.043) compared to distal type colitis. CRP levels were significantly higher in cases with extensive colitis/pancolitis (p=0.015). No relationship was identified between laboratory parameters and the endoscopic location of involvement in CD.
Conclusion: Although hemoglobin value, ESR and CRP levels are helpful in determining the location of involvement in UC, their effects have not been observed in CD. In addition to these basic laboratory values, other parameters should also be taken into consideration in the evaluation of patients.

Keywords

C-reactive protein, Crohn, Erythrocyte Sedimentation Rate, Ulcerative Colitis

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