Safra Taşı Hastalığının Serum RBP4 Düzeyi, D Vitamini, Lipid Profili, İnsülin Direnci ve Ürik Asit Düzeyleri ile İlişkisi

Year 2024, Volume: 6 Issue: 2, 161 - 169, 30.06.2024

Bediz Kurt İnci , Kamil İnci , Özge Paşaoğlu , Hatice Pasaoglu , Gıyasettin Şükrü Dumlu

https://doi.org/10.52827/hititmedj.1424453

Abstract

Amaç: Safra taşları ile ilişkilendirilen metabolik parametreler birçok çalışmanın konusunu oluşturmaktadır. RBP4, bir adipokin olup metabolik hastalıklarla ilişkilendirilmiştir; ancak bildiğimiz dahilinde, safra taşı hastalığı ile ilişkisini belirleyen bir çalışma bulunmamaktadır. Çalışmamızda, öncelikle serum RBP4 olmak üzere safra taşı ile ilişkilendirilen biyokimyasal parametreleri değerlendirmeyi amaçladık.
Gereç ve Yöntem: 2015-2016 yılları arasında gastroenteroloji kliniğine başvuran 80 hastanın abdominal ultrason, serum biyokimyasal testler, lipid profilleri, ürik asit, insulin ve açlık glukoz değerleri mevcuttu ve çalışmaya dahil edildi. RBP4 seviyeleri, alınan serum örneklerinde analiz edildi.
Bulgular: Seksen hastanın 42’sinde safra taşı bulunurken, 38’inde yoktu. Biyokimyasal parametreler arasında, toplam kolesterol değerleri (p= 0.483), LDL değerleri (p=0.224) ve trigliserit değerleri (p=0.764) açısından gruplar arasında anlamlı fark bulunmamıştır. İki grup arasında HDL değerleri açısından anlamlı fark gözlemlenmiştir (p=0.017). Serum ürik asit (p=0.411), açlık glukozu (p=0.214), açlık insulin ve HOMA-IR skoru (p=0.157), vitamin D seviyeleri (p=0.340) açısından iki grup arasında anlamlı fark bulunmamıştır. Çalışmaya katılan kişilerin incelenen serum RBP4 seviyelerinin ortalama±SD değerleri kontrol grubunda 40,24±7,12, hasta grubunda ise 39,75±8,55 olarak belirlenmiştir. İki grup arasında anlamlı fark bulunmamıştır (p=0.776). Korelasyon analizlerinde; RBP4 ile vitamin D seviyeleri (r: 0.277, p= 0.013), toplam kolesterol (r: 0.268, p=0.016), trigliserit (r: 0.387, p<0.001), GGT (r: 0.294, p=0.008), AST (r: 0.299, p=0.007) ve ürik asit (r: 0.255, p=0.022) arasında anlamlı pozitif korelasyon bulunmuştur.
Sonuç: Sonuç olarak, çalışmamızda safra kesesi taşları ile RBP4, vitamin D, LDL, TG, toplam kolesterol, ürik asit ve HOMA-IR arasında anlamlı ilişki bulunamamıştır. Ancak çalışmamızda saptanan D vitamin ve RBP4 düzeyi arasındaki pozitif korelasyonun gelecekteki çalışmalar için yol gösterici olduğu düşünülmüştür.

Keywords

Kolelitiazis, RBP4, Safra Taşı Hastalığı

Ethical Statement

Hastanın Gazi Ünivestesi Tıp Fakültesinden alınan 26.5.2014 tarihli etik kurul onam belgesi ek dosya olarak ana makale metini ile yüklenmiştir sunulmuştur.

Supporting Institution

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Thanks

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The Relationship of Gallestone Disease with Serum RBP4 Level, Vitamın D, Lipid Profile, Insulin Resistance and Uric Acid Levels

Abstract

Objective: The metabolic parameters associated with gallstones are the subject of numerous studies. RBP4, an adipokine, has been linked to various metabolic diseases; however, no study in the literature establishes its relationship with gallstone disease. Therefore, our study aimed to evaluate the biochemical parameters associated with gallstone disease, primarily serum RBP4.
Material and Method: Between 2015 and 2016, abdominal ultrasound, serum biochemical tests, lipid profiles, uric acid, insulin, and fasting glucose values were available for 80 patients who presented to our hospital’s gastroenterology clinic, were included in the study. RBP4 levels were analyzed in the serum samples obtained from the patients.
Results: Out of the 80 participants in the study, 42 had gallstones, while 38 did not. Among the biochemical parameters, no significant difference was found between the groups in terms of total cholesterol values (p= 0.483), LDL values (p=0.224), and TG values (p=0.764). A significant difference was observed between the two groups regarding HDL values(p=0.017). No significant difference was found between the two groups in terms of serum uric acid (p=0.411), fasting glucose (p=0.214), fasting insulin, HOMA-IR score (p=0.157), and vitamin D levels (p=0.340). The mean±SD values of the studied serum RBP-4 levels in the participants were determined as 40.24±7.12 in the control group and 39.75±8.55 in the patient group. No statistically significant difference was found between the two groups (p=0.776). In correlation analyses, a significant positive correlation was found between RBP4 and vitamin D levels (r: 0.277, p= 0.013), total cholesterol (r: 0.268, p=0.016), triglycerides (r: 0.387, p<0.001), GGT (r: 0.294, p=0.008), AST (r: 0.299, p=0.007), and uric acid (r: 0.255, p=0.022).
Conclusion: In conclusion, our study did not find a statistically significant relationship between gallstones and RBP4, vitamin D, LDL, TG, total cholesterol, uric acid, and HOMA-IR. However, our study found a positive correlation between vitamin D levels and RBP4. This has guided future research.

Keywords

Cholelithiasis, Gallstone Disease, RBP4

Project Number

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