Kanser Çoklu İlaç Dirençliliğinin Yenilmesinde İmidazopiridinler: Yeni Umutlar

Year 2024, Volume: 6 Issue: 2, 216 - 225, 30.06.2024

Cevriye Yıldırım , Erkan Yurtcu

https://doi.org/10.52827/hititmedj.1425486

Abstract

Kanser tedavisinde kullanılan farmakoterapi protokolleri ilaçlara bağlı toksisite ve ilacın etkinliğinin azalması gibi nedenlerden ötürü birçok hasta için tedavi edici olmaktan uzaktır. Çoklu ilaç direnci kanser hücresinin birbirinden farklı ilaç gruplarına ya da ilaç kombinasyonlarına karşı geliştirdiği bir savunma mekanizmasıdır. En önemli nedenlerinden biri hücreden ilaç atımını sağlayan ABC taşıyıcılarının etkinliğinin ya da sayısının artmasıdır. Birçok biyomolekülün yapısına katılan imidazopiridinler uzun yıllardır laboratuvar koşullarında üretilebilmektedirler. İmidazopiridinler kanser hücrelerini çeşitli yollarla öldürebilen etkin antikanser ajanlardır. Bu derlemede imidazopiridinlerin kanser hücrelerinde ABC taşıyıcılarını hedefleyerek çoklu ilaç direncinin üstesinden gelinmesinde kullanıldığı çalışmaların ayrıntılı bir özetini sunduk. Bu amaçla sentezlenen ve ilaç olarak kullanılan ajanlar ile henüz klinik denemelerine başlanmamış bileşiklerin sentezlenme stratejilerini ve laboratuvar sonuçlarını toplu halde değerlendirdik. Birkaç imidazopiridin türevinin reçete edilebilen ilaçlar olarak piyasaya sunulması bu moleküllerin potansiyelini yansıtmaktadır. Hedefe yönelik tedavi sağlayabilen ajanların klinikte daha sık kullanılacağını ve tedavi başarılarını iyileştireceğini düşünüyoruz.

Keywords

ABC Taşıyıcılar, çoklu ilaç direnci, imidazopiridin, kanser

Imidazopyridines in Overcoming Cancer Multidrug Resistance: New Hopes

Abstract

Pharmacotherapy protocols used in cancer treatment are far from curative for many patients due to reasons such as drug-related toxicity and decreased effectiveness of the drug. Multidrug resistance is a defense mechanism developed by the cancer cell against different drug groups or drug combinations. One of the most important reasons is the increase in the efficiency or number of ABC transporters that ensure drug removal from the cell. Imidazopyridines, which are incorporated into the structure of many biomolecules, have been produced under laboratory conditions for many years. Imidazopyridines are effective anticancer agents that can kill cancer cells in various ways. In this review, we presented a detailed summary of studies in which imidazopyridines were used to overcome multidrug resistance by targeting ABC transporters in cancer cells. For this purpose, we collectively evaluated the synthesis strategies and laboratory results of the agents synthesized and used as drugs and the compounds whose clinical trials have not yet started. The introduction of several imidazopyridine derivatives as prescription drugs reflects the potential of these molecules. We think that agents that can provide targeted therapy will be used more frequently in the clinic and will improve treatment success.

Keywords

ABC Transporters, cancer, imidazopyridine, multidrug resistance

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