Tüp Bebek Tedavisinde Polikistik Over Sendromu ve Açıklanamayan İnfertilite Hasta Gruplarında Serum ve Folikül Sıvısı Melatonin Düzeylerinin Tüp Bebek Başarısı Üzerine Etkisi

Year 2025, Volume: 7 Issue: 1, 70 - 77, 25.02.2025

Deniz Taşkıran , Özgür Koçak , Ercan Ayaz , Ümit Görkem , Cihan Toğrul

https://doi.org/10.52827/hititmedj.1458893

Abstract

Amaç: Açıklanamayan infertilite ve tüp bebek tedavisi gören PKOS (Polikistik Over Sendromu) hastalarında serum
ve folikül sıvısı melatonin düzeyleri arasındaki farkı araştırmak ve melatonin düzeyinin oosit kalitesi, embriyo sayısı
ve klinik gebelik üzerine etkilerini araştırmak.
Gereç ve Yöntem: Bu prospektif çalışmaya, açıklanamayan infertilitesi olan kadınlar (n=26) ve polikistik over
sendromlu (n=26) tüp bebek tedavisine başlayan kadınlar dahil edildi. Grupların serum ve foliküler sıvısındaki
melatonin düzeyleri ELIZA yöntemi kullanılarak test edildi. Ayrıca gruplar arasındaki melatonin düzeyi farklılığının
IVF başarısına etkisi araştırıldı.
Bulgular: Polikistik over sendromlu hastaların serum melatonin düzeyleri anlamlı düzeyde az idi (p=0.018).
Foliküler sıvıdaki melatonin düzeyleri her iki grupta da benzerdi (p=0.701). Toplam oosit, M2 oosit, PN2 oosit, A
sınıfı embriyo, ikinci gün embriyo sayısı ve transfer edilen embriyo sayısı açısından gruplar arasında anlamlı fark
yoktu (p>0.05). Serum ve foliküler sıvı melatonin düzeyleri arasında anlamlı bir ilişki saptanmadı (p>0.05). Klinik
gebelik ile melatonin düzeyi arasında anlamlı bir ilişki bulunmadı (p>0.05). Gruplar arasında yaş, kilo, boy ve
vücut kitle indeksi açısından istatistiksel fark yoktu (p>0.05).
Sonuç: Çalışmamızda polikistik over sendromlu infertil kadınlarda serum melatonin düzeyleri daha düşüktü.
Bunun nedeni yüksek melatonin tüketimi olabilir. Ancak serum ve foliküler sıvıdaki melatonin düzeylerinin IVF
sonucuna doğrudan bir etkisinin olmadığı görüldü.

Keywords

Açıklanamayan İnfertilite, Foliküler Sıvı, Melatonin, Polikistik Over Sendromu

Ethical Statement

Çalışma için Hitit Üniversitesi Tıp Fakültesi Klinik Araştırmalar Etik Kurulu tarafından 11/08/2021 tarihli 488 karar numaralı etik kurul onayı alınmıştır.

Supporting Institution

Çalışma için herhangi bir kurumdan yardım alınmamıştır.

Project Number

1

Thanks

yok

The Effect of Serum and Follicle Fluid Melatonin Levels on In-Vitro Fertilization Success Between Polycystic Ovary Syndrome and Unexplained Infertility Patient Groups in In-Vitro Fertilization

Abstract

Objective: To investigate the difference in the serum melatonin and follicle fluid melatonin levels at unexplained
infertility and polycystic ovary syndrome (PCOS) patients who underwent in-vitro fertilization (IVF) treatment,
and to investigate whether the melatonin level affects oocyte quality, embryo number, and clinical pregnancy.
Material and Method: Women with unexplained infertility (n=26) and women with the polycystic ovarian
syndrome (n=26) who started IVF treatment were included in this prospective trial. The levels of melatonin in
the groups’ were tested using the enzyme-linked immunosorbent (ELIZA) method. In addition, the effect of the
difference in melatonin levels between the groups on IVF success was investigated.
Results: Patients with the polycystic ovarian syndrome had significantly low serum melatonin levels (p=0.018).
Melatonin levels in follicular fluid were similar in both groups (p=0.701). Total oocyte, M2 oocyte, PN2 oocyte,
grade A embryo, second-day embryo count, and the number of transferred embryos did not differ across the
groups (p>0.05). There was no significant relationship between serum and follicular fluid melatonin levels
(p>0.05). There was no significant relationship between clinical pregnancy and melatonin level (p>0.05). There
was no statistical difference between the groups regarding age, weight, height, and body mass index (p>0.05).
Conclusion: In our study, serum melatonin levels were lower in infertile women with polycystic ovary syndrome. This may be due to high melatonin consumption. However, melatonin levels in the serum and follicular fluid had
no direct effect on IVF outcomes.

Keywords

Unexplained infertility, Follicular Fluid, Melatonin, PCOS

Ethical Statement

Approval for the study was obtained from the Hitit University Clinical Research Ethics Committee on 11/08/2021. Decision no: 488.

Supporting Institution

none

Project Number

1

Thanks

none

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