Serum ve Folikül Sıvısı Fetuin-B Düzeylerinin Tüp Bebek Tedavisi Üzerine Etkisi

Year 2025, Volume: 7 Issue: 2, 235 - 243, 23.06.2025

Orhan Ay , Cihan Toğrul , Ümit Görkem , Ercan Ayaz , Deniz Taşkıran

https://doi.org/10.52827/hititmedj.1585893

Abstract

Amaç: İnfertilite tanısı olan ve tüp bebek tedavisi gören açıklanamayan infertilite, polikistik over sendromu ve kötü over yanıtlı hasta gruplarında serum ve folikül sıvılarındaki fetuin-B düzeyleri arasındaki farkı araştırmak ve fetuin -B düzeyinin oosit kalitesi, embriyo sayısı ve klinik gebelik üzerine etkisini araştırmaktır.
Gereç ve Yöntem: Bu prospektif çalışmaya, infertilite tanılı ve tüp bebek tedavisine başlayan açıklanamayan infertilitesi olan kadınlar (n=25), polikistik over sendromlu kadınlar (n=25) ve kötü over yanıtı olan kadınlar (n=25) dahil edildi. Grupların serum ve foliküler sıvısındaki fetuin-B düzeyleri ELIZA yöntemi kullanılarak test edildi. Ayrıca gruplar arasındaki fetuin-B düzeyi farklılığının üreme başarısına etkisi araştırıldı.
Bulgular: Her üç grupta da folikül sıvısından ölçülen fetuin-B değerinin dağılımları arasındaki farklar istatistiksel olarak anlamlı değildi (p>0.05). Öte yandan serumda bakılan fetuin-B düzeyi istatistiksel olarak anlamlı şekilde PCOS grubunda kötü over grubundan daha yüksekti (p<0.05). Post Hoc olarak yapılan Mann Whitney U testi sonuçlarına göre, sadece PKOS grubu ile kötü over grubu arasındaki serum fetuin-B düzeyi arasındaki farklar istatistiksel olarak anlamlıydı (p<0.05).
Sonuç: PKOS grubunda serum fetuin-B ve folikül sıvısındaki fetuin-B arasında istatistiksel olarak anlamlı bir ilişki bulunamadı. Ancak açıklanamayan infertilite grubunda folikül sıvısındaki fetuin-B seviyesi ile biyokimyasal gebelik ve aynı zamanda klinik gebelik sayısı arasında istatistiksel olarak anlamlı ve negatif yönde ilişki bulundu. Fetuin-B düzeyi bu bakımdan açıklanamayan infertilite grubunda in vitro fertilizasyon (IVF) sürecinin sonuçlarını tahmin etmede prediktif değere sahip olabilir.

Keywords

Açıklanamayan kısırlık , Fetuin-B , foliküler sıvı , PKOS , tüp bebek tedavisi

Project Number

409

The Effect of Serum and Follicular Fluid Fetuin-B Levels on In Vitro Fertilization Treatment

Abstract

Objective: The aim of this study was to investigate the difference between fetuin-B levels in serum and follicular fluid of patients with unexplained infertility, polycystic ovary syndrome (PCOS) and poor ovarian response undergoing In vitro fertilization (IVF) treatment and to investigate the effect of fetuin-B levels on oocyte quality, embryo number and clinical pregnancy.
Material and Method: In this prospective study, women with unexplained infertility (n=25), women with polycystic ovary syndrome (n=25), and women with poor ovarian response (n=25) who were diagnosed with infertility and started IVF treatment were included. Fetuin-B levels in serum and follicular fluid of the groups were tested using the ELISA method. In addition, the effect of the difference in fetuin-B levels between the groups on reproductive success was investigated.
Results: The differences between the distributions of fetuin-B levels measured in follicular fluid were not statistically significant in all three groups (p>0.05). On the other hand, the fetuin-B level measured in serum was statistically significantly higher in the PCOS group than in the bad ovary group (p<0.05). According to the results of the Mann-Whitney U test performed as post-hoc, only the differences in serum fetuin-B levels between the PCOS group and the bad ovary group were statistically significant (p<0.05).
Conclusion: No statistically significant correlation was found between serum fetuin-B and fetuin-B in follicular fluid in the PCOS group. However, in the unexplained infertility group, there was a statistically significant and negative correlation between the level of fetuin-B in the follicular fluid and the number of biochemical pregnancies as well as the number of clinical pregnancies. In this respect, fetuin-B level may have predictive value in predicting the outcome of in vitro fertilization (IVF) in the unexplained infertility group.

Keywords

Fetuin-B , follicular fluid , in vitro fertilization , PCOS , unexplained infertility

Ethical Statement

Approval for the study was obtained from the Hitit University Clinical Research Ethics Committee on 08/09/2021. Decision no: 490.

Project Number

409

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