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Geleneksel Olmayan Topikal Negative Basınç Uygulamarı

Year 2025, Volume: 7 Issue: 3, 453 - 460, 13.10.2025
https://doi.org/10.52827/hititmedj.1686616

Abstract

Topikal negatif basınç, son yıllarda kronik yara kapanmasında akla gelen ilk tedavi yöntemlerinden biri olup, özellikle rekonstrüktif cerrahide topikal negatif basınç tedavisi sıklıkla kullanılan kesin bir tedavi yöntemidir. Bu makalenin amacı literatürdeki geleneksel olmayan uygulamaları derlemek ve bilim insanlarını bu yöntemin farklı alanlarda kullanılabilirliği konusunda düşünce oluşturmaya teşvik etmektir. Geleneksel olmayan topikal negatif basınç uygulamaları için yapılan deneysel ve klinik araştırmalar göz önüne alındığında, birçoğunda olumlu sonuçlar elde edilmesine rağmen, yeterli sayıda denek veya hasta olmadığından daha kapsamlı araştırmalara ihtiyaç duyulduğu anlaşılmaktadır. Özellikle deneysel olarak kanıtlanmış hipotermi kaynaklı miyokard enfarktüsü ve flep gecikmesi sorunlarında klinik pratiğe uygulanabileceğini düşünmekteyiz.

References

  • Voinchet V, Magalon G. Vacuum assisted closure. Wound healing by negative pressure. Ann Chir Plast Esthet 1996;41(5):583–589.
  • Morykwas MJ, Argenta LC, Shelton-Brown EI, McGuirt W. Vacuum-Assisted Closure: A New Method for Wound Control and Treatment: Animal Studies and Basic Foundation. Ann Plast Surg 1997;38(6):553–562.
  • Argenta LC, Morykwas MJ. Vacuum-assisted closure: a new method for wound control and treatment: clinical experience. Ann Plast Surg 1997;38(6):563–576.
  • Hallberg H, Holmström H. Vaginal construction with skin grafts and vacuum-assisted closure. Scand J Plast Reconstr Surg Hand Surg 2003;37(2):97–101.
  • Erdmann D, Drye C, Heller L, Wong MS, Levin SL. Abdominal wall defect and enterocutaneous fistula treatment with the Vacuum-Assisted Closure (V.A.C.) system. Plast Reconstr Surg 2001;108(7):2066–2068.
  • Attinger C, Cooper P. Soft tissue reconstruction for calcaneal fractures or osteomyelitis. Orthop Clin North Am 2001;32(1):135–170.
  • Tang AT, Okri SK, Haw MP. Vacuum-assisted closure to treat deep sternal wound infection following cardiac surgery. J Wound Care 2000;9(5):229–230.
  • Bludau M, Fuchs HF, Herbold T, et al. Results of endoscopic vacuum-assisted closure device for treatment of upper GI leaks. Surg Endosc 2018;32(4):1906–1914.
  • Greer SE, Longaker MT, Margiotta M, Mathews AJ, Kasabian A. The use of subatmospheric pressure dressing for the coverage of radial forearm free flap donor-site exposed tendon complications. Ann Plast Surg 1999;43(5):551–554.
  • Tan APP, Chng JK. Fish Skin Acellular Dermal Matrix Combined With Negative Pressure Wound Therapy for Diabetic Foot Ulcers. Cureus. 2025;17(3):e80488.
  • Schlatterer DR, Hirschfeld AG, Webb LX. Negative Pressure Wound Therapy in Grade IIIB Tibial Fractures: Fewer Infections and Fewer Flap Procedures. Clin Orthop 2015;473(5):1802–1811.
  • Baskett TF. Alexander Graham Bell and the vacuum jacket for assisted respiration. Resuscitation 2004;63(2):115–117.
  • Spalding JM, Opie L. Artificial respiration with the Tunnicliffe breathing-jacket. Lancet 1958;1(7021):613–615.
  • Shneerson JM. Assisted ventilation. 5. Non-invasive and domiciliary ventilation: negative pressure techniques. Thorax 1991;46(2):131–135.
  • Münster K, Andersen U, Mikkelsen J, Pettersson G. Vacuum assisted venous drainage. Perfusion 1999;14(6):419–423.
  • Mustoe TA. The mechanical bra for breast enlargement. Aesthet Surg J 2000;20(2):176–178.
  • Greco RJ. Nonsurgical breast enhancement—fact or fiction. Plast Reconstr Surg 2002;110(1):337–339.
  • Schlenz I, Kaider A. The Brava External Tissue Expander: Is Breast Enlargement without Surgery a Reality. Plast Reconstr Surg 2007;120(6):1680–1689.
  • Baudoin J, Jafari P, Meuli J, Applegate LA, Raffoul W. Topical Negative Pressure on Burns: An Innovative Method for Wound Exudate Collection. Plast Reconstr Surg Glob Open 2016;4(11):e1117.
  • Lin D, Kao Y, Chen C, Wang H, Chiu W. Negative pressure wound therapy for burn patients: A meta-analysis and systematic review. Int Wound J 2021;18(1):112–123.
  • Kamolz LP, Andel H, Haslik W, Winter W, Meissl G, Frey M. Use of subatmospheric pressure therapy to prevent burn wound progression in human: first experiences. Burns 2004;30(3):253–258.
  • Wasiak J, Cleland H. Topical negative pressure (TNP) for partial thickness burns. Cochrane Database Syst Rev 2007;(3):CD006215.
  • Lindstedt S, Malmsjö M, Ingemansson R. The effect of different topical negative pressures on microvascular blood flow in reperfused myocardium during hypothermia. Innov Phila Pa 2007;2(5):231–236.
  • Saadi A, Perentes JY, Gonzalez M, et al. Vacuum-Assisted Closure Device: A Useful Tool in the Management of Severe Intrathoracic Infections. Ann Thorac Surg 2011;91(5):1582–1589.
  • Sciortino CM, Mundinger GS, Kuwayama DP, Yang SC, Sussman MS. Case report: treatment of severe subcutaneous emphysema with a negative pressure wound therapy dressing. Eplasty 2009;9:e1.
  • Seyfried F, Reimer S, Miras AD, et al. Successful treatment of a gastric leak after bariatric surgery using endoluminal vacuum therapy. Endoscopy 2013;45 Suppl 2 UCTN:E267–268.
  • Newton NJ, Sharrock A, Rickard R, Mughal M. Systematic review of the use of endo-luminal topical negative pressure in oesophageal leaks and perforations. Dis Esophagus 2017;30(3):1–5.
  • Kollmann C, Kusnezov B, Kollmann L, et al. The effects of endoscopic vacuum therapy for non-operative treatment of anastomotic leakage on oncological outcomes in rectal cancer patients. Langenbecks Arch Surg 2025;410(1):107.
  • Kajihara I, Jinnin M, Yamada S, et al. Successful treatment of skin fistulas in systemic sclerosis patients with the combination of topical negative pressure therapy and split-thickness skin grafting. Mod Rheumatol 2014;24(2):374–376.
  • Menezes PFC, Requena MB, Bagnato VS. Optimization of photodynamic therapy using negative pressure. Photomed Laser Surg 2014;32(5):296–301.
  • Lee JW, Han YS, Kim SR, Kim HK, Kim H, Park JH. A rabbit model of fat graft recipient site preconditioning using external negative pressure. Arch Plast Surg 2015;42(2):150–158.
  • Aydin OE, Algan S, Tan O, Demirci E, Keles ON, Kantarci A. A novel method for flap delay vacuum assisted flap delay: an experimental study in rabbits. J Plast Surg Hand Surg 2019;53(4):208–215.
  • Brown CA, Ghareeb PA. Early Experience with External Negative Pressure Delay in Free Anterolateral Thigh Perforator Flap Reconstruction. Plast Reconstr Surg Glob Open 2021;9(6):e3606.
  • Yu P, Yu N, Yang X, Jin X, Lu H, Qi Z. Clinical Efficacy and Safety of Negative-Pressure Wound Therapy on Flaps: A Systematic Review. J Reconstr Microsurg 2017;33(05):358–366.
  • Liang K, Ke Z, Huang J, Fei X, Qi L, Wang J. Analysis of vacuum negative pressure therapy and traditional Chinese medicine lavage in combination with tadalafil for vascular erectile dysfunction. Front Reprod Health 2024;6:1335239.
  • Currie RV, Durand CJ, Bond J. Reducing the incidence of problematic seroma formation and skin necrosis post-lymphadenectomy: Triple action of topical tranexamic acid, negative pressure wound therapy, and prolonged drainage. J Plast Reconstr Aesthet Surg 2024;94:54–61.
  • Pelham FR, Kubiak EN, Sathappan SS, Di Cesare PE. Topical negative pressure in the treatment of infected wounds with exposed orthopaedic implants. J Wound Care 2006;15(3):111–116.
  • Satteson ES, Crantford JC, Wood J, David LR. Outcomes of Vacuum-Assisted Therapy in the Treatment of Head and Neck Wounds. J Craniofac Surg 2015;26(7):e599–602.
  • Goon PKY, Dalal M. Limb-Threatening Extravasation Injury: Topical Negative Pressure and Limb Salvage. Plast Reconstr Surg 2006;117(3):1064–1065.
  • Hou S, Shi Z, Li X, Yang R, Song Y, Zeng Z. Combined negative pressure wound therapy with new wound dressings to repair a ruptured giant omphalocele in a neonate: a case report and literature review. BMC Pediatr 2025;25(1):44.

Non-Traditional Topical Negative Pressure Applications

Year 2025, Volume: 7 Issue: 3, 453 - 460, 13.10.2025
https://doi.org/10.52827/hititmedj.1686616

Abstract

Topical negative pressure is one of the first treatment methods that comes to mind for chronic wound closure in recent years, and especially in reconstructive surgery, topical negative pressure therapy is a definitive treatment method that is frequently used. The purpose of this article is to compile non-traditional applications in the literature and to prompt scientists to form thoughts on the usability of this method in different areas. Considering the experimental and clinical research conducted for non-traditional topical negative pressure applications, although positive results were obtained in many of them, it is understood that more comprehensive research is required since there are not enough subjects or patients. We think that it can be applied to clinical practice, especially in the experimentally proven hypothermia-induced myocardial infarction and flap delay issues.

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References

  • Voinchet V, Magalon G. Vacuum assisted closure. Wound healing by negative pressure. Ann Chir Plast Esthet 1996;41(5):583–589.
  • Morykwas MJ, Argenta LC, Shelton-Brown EI, McGuirt W. Vacuum-Assisted Closure: A New Method for Wound Control and Treatment: Animal Studies and Basic Foundation. Ann Plast Surg 1997;38(6):553–562.
  • Argenta LC, Morykwas MJ. Vacuum-assisted closure: a new method for wound control and treatment: clinical experience. Ann Plast Surg 1997;38(6):563–576.
  • Hallberg H, Holmström H. Vaginal construction with skin grafts and vacuum-assisted closure. Scand J Plast Reconstr Surg Hand Surg 2003;37(2):97–101.
  • Erdmann D, Drye C, Heller L, Wong MS, Levin SL. Abdominal wall defect and enterocutaneous fistula treatment with the Vacuum-Assisted Closure (V.A.C.) system. Plast Reconstr Surg 2001;108(7):2066–2068.
  • Attinger C, Cooper P. Soft tissue reconstruction for calcaneal fractures or osteomyelitis. Orthop Clin North Am 2001;32(1):135–170.
  • Tang AT, Okri SK, Haw MP. Vacuum-assisted closure to treat deep sternal wound infection following cardiac surgery. J Wound Care 2000;9(5):229–230.
  • Bludau M, Fuchs HF, Herbold T, et al. Results of endoscopic vacuum-assisted closure device for treatment of upper GI leaks. Surg Endosc 2018;32(4):1906–1914.
  • Greer SE, Longaker MT, Margiotta M, Mathews AJ, Kasabian A. The use of subatmospheric pressure dressing for the coverage of radial forearm free flap donor-site exposed tendon complications. Ann Plast Surg 1999;43(5):551–554.
  • Tan APP, Chng JK. Fish Skin Acellular Dermal Matrix Combined With Negative Pressure Wound Therapy for Diabetic Foot Ulcers. Cureus. 2025;17(3):e80488.
  • Schlatterer DR, Hirschfeld AG, Webb LX. Negative Pressure Wound Therapy in Grade IIIB Tibial Fractures: Fewer Infections and Fewer Flap Procedures. Clin Orthop 2015;473(5):1802–1811.
  • Baskett TF. Alexander Graham Bell and the vacuum jacket for assisted respiration. Resuscitation 2004;63(2):115–117.
  • Spalding JM, Opie L. Artificial respiration with the Tunnicliffe breathing-jacket. Lancet 1958;1(7021):613–615.
  • Shneerson JM. Assisted ventilation. 5. Non-invasive and domiciliary ventilation: negative pressure techniques. Thorax 1991;46(2):131–135.
  • Münster K, Andersen U, Mikkelsen J, Pettersson G. Vacuum assisted venous drainage. Perfusion 1999;14(6):419–423.
  • Mustoe TA. The mechanical bra for breast enlargement. Aesthet Surg J 2000;20(2):176–178.
  • Greco RJ. Nonsurgical breast enhancement—fact or fiction. Plast Reconstr Surg 2002;110(1):337–339.
  • Schlenz I, Kaider A. The Brava External Tissue Expander: Is Breast Enlargement without Surgery a Reality. Plast Reconstr Surg 2007;120(6):1680–1689.
  • Baudoin J, Jafari P, Meuli J, Applegate LA, Raffoul W. Topical Negative Pressure on Burns: An Innovative Method for Wound Exudate Collection. Plast Reconstr Surg Glob Open 2016;4(11):e1117.
  • Lin D, Kao Y, Chen C, Wang H, Chiu W. Negative pressure wound therapy for burn patients: A meta-analysis and systematic review. Int Wound J 2021;18(1):112–123.
  • Kamolz LP, Andel H, Haslik W, Winter W, Meissl G, Frey M. Use of subatmospheric pressure therapy to prevent burn wound progression in human: first experiences. Burns 2004;30(3):253–258.
  • Wasiak J, Cleland H. Topical negative pressure (TNP) for partial thickness burns. Cochrane Database Syst Rev 2007;(3):CD006215.
  • Lindstedt S, Malmsjö M, Ingemansson R. The effect of different topical negative pressures on microvascular blood flow in reperfused myocardium during hypothermia. Innov Phila Pa 2007;2(5):231–236.
  • Saadi A, Perentes JY, Gonzalez M, et al. Vacuum-Assisted Closure Device: A Useful Tool in the Management of Severe Intrathoracic Infections. Ann Thorac Surg 2011;91(5):1582–1589.
  • Sciortino CM, Mundinger GS, Kuwayama DP, Yang SC, Sussman MS. Case report: treatment of severe subcutaneous emphysema with a negative pressure wound therapy dressing. Eplasty 2009;9:e1.
  • Seyfried F, Reimer S, Miras AD, et al. Successful treatment of a gastric leak after bariatric surgery using endoluminal vacuum therapy. Endoscopy 2013;45 Suppl 2 UCTN:E267–268.
  • Newton NJ, Sharrock A, Rickard R, Mughal M. Systematic review of the use of endo-luminal topical negative pressure in oesophageal leaks and perforations. Dis Esophagus 2017;30(3):1–5.
  • Kollmann C, Kusnezov B, Kollmann L, et al. The effects of endoscopic vacuum therapy for non-operative treatment of anastomotic leakage on oncological outcomes in rectal cancer patients. Langenbecks Arch Surg 2025;410(1):107.
  • Kajihara I, Jinnin M, Yamada S, et al. Successful treatment of skin fistulas in systemic sclerosis patients with the combination of topical negative pressure therapy and split-thickness skin grafting. Mod Rheumatol 2014;24(2):374–376.
  • Menezes PFC, Requena MB, Bagnato VS. Optimization of photodynamic therapy using negative pressure. Photomed Laser Surg 2014;32(5):296–301.
  • Lee JW, Han YS, Kim SR, Kim HK, Kim H, Park JH. A rabbit model of fat graft recipient site preconditioning using external negative pressure. Arch Plast Surg 2015;42(2):150–158.
  • Aydin OE, Algan S, Tan O, Demirci E, Keles ON, Kantarci A. A novel method for flap delay vacuum assisted flap delay: an experimental study in rabbits. J Plast Surg Hand Surg 2019;53(4):208–215.
  • Brown CA, Ghareeb PA. Early Experience with External Negative Pressure Delay in Free Anterolateral Thigh Perforator Flap Reconstruction. Plast Reconstr Surg Glob Open 2021;9(6):e3606.
  • Yu P, Yu N, Yang X, Jin X, Lu H, Qi Z. Clinical Efficacy and Safety of Negative-Pressure Wound Therapy on Flaps: A Systematic Review. J Reconstr Microsurg 2017;33(05):358–366.
  • Liang K, Ke Z, Huang J, Fei X, Qi L, Wang J. Analysis of vacuum negative pressure therapy and traditional Chinese medicine lavage in combination with tadalafil for vascular erectile dysfunction. Front Reprod Health 2024;6:1335239.
  • Currie RV, Durand CJ, Bond J. Reducing the incidence of problematic seroma formation and skin necrosis post-lymphadenectomy: Triple action of topical tranexamic acid, negative pressure wound therapy, and prolonged drainage. J Plast Reconstr Aesthet Surg 2024;94:54–61.
  • Pelham FR, Kubiak EN, Sathappan SS, Di Cesare PE. Topical negative pressure in the treatment of infected wounds with exposed orthopaedic implants. J Wound Care 2006;15(3):111–116.
  • Satteson ES, Crantford JC, Wood J, David LR. Outcomes of Vacuum-Assisted Therapy in the Treatment of Head and Neck Wounds. J Craniofac Surg 2015;26(7):e599–602.
  • Goon PKY, Dalal M. Limb-Threatening Extravasation Injury: Topical Negative Pressure and Limb Salvage. Plast Reconstr Surg 2006;117(3):1064–1065.
  • Hou S, Shi Z, Li X, Yang R, Song Y, Zeng Z. Combined negative pressure wound therapy with new wound dressings to repair a ruptured giant omphalocele in a neonate: a case report and literature review. BMC Pediatr 2025;25(1):44.
There are 40 citations in total.

Details

Primary Language English
Subjects Plastic Reconstructive and Aesthetic Surgery
Journal Section Review
Authors

Said Algan 0000-0001-8516-0318

İhtişam Zafer Cengiz 0000-0002-9372-5830

Publication Date October 13, 2025
Submission Date April 29, 2025
Acceptance Date July 25, 2025
Published in Issue Year 2025 Volume: 7 Issue: 3

Cite

AMA Algan S, Cengiz İZ. Non-Traditional Topical Negative Pressure Applications. Hitit Medical Journal. October 2025;7(3):453-460. doi:10.52827/hititmedj.1686616