Research Article
BibTex RIS Cite

Bilgisayarlı Tomografi Kılavuzluğunda Perkütan Pelvik Kemik Biyopsisi: Teknik Başarı, Tanısal Performans ve Güvenilirlik

Year 2025, Volume: 7 Issue: 3, 369 - 378, 13.10.2025
https://doi.org/10.52827/hititmedj.1687115

Abstract

Amaç: BT kılavuzluğunda gerçekleştirilen pelvik kemik biyopsilerinin teknik başarısını, tanısal performansını ve komplikasyonlarını değerlendirmek.
Gereç ve Yöntem: 2017–2024 yılları arasında BT eşliğinde pelvik kemik (sakrum, ilium, iskium, pubis, femur proksimali) biyopsisi yapılan 50 hasta (32 kadın, 18 erkek; yaş ortalaması 57,5 ± 15,5; aralık 20–91) çalışmaya dahil edildi. Biyopsiler, en az 5 yıl deneyimli girişimsel radyologlar tarafından gerçekleştirildi. Lezyon boyutu, lokasyonu, tipi (litik, sklerotik, mikst), patoloji sonuçları, teknik başarı, tanısal performans ve komplikasyonlar hasta dosyalarından ve Picture Archiving and Communication System (PACS) üzerinden kaydedildi. Komplikasyonlar, Society of Interventional Radiology (SIR) rehberine göre minör veya majör olarak sınıflandırıldı.
Bulgular: Teknik başarı %100 (50/50) idi. Patoloji sonuçları 25 (%50) malign, 15 (%30) benign ve 10 (%20) nondiagnostik olarak raporlandı; tanısal performans %80 olarak hesaplandı. Nondiagnostik lezyonlar, malign (p=0,002) ve benign (p<0,001) lezyonlara kıyasla anlamlı derecede daha küçüktü. Lezyonların 16’sı litik (%32), 17’si sklerotik (%34) ve 17’si mikst (%34) tipteydi. Lezyon tipi ile tanısal sonuçlar (diagnostik vs. nondiagnostik) arasında anlamlı ilişki saptandı (p=0,025); nondiagnostik lezyonların %70’i sklerotikti. İki hastada ağrı, bir hastada geçici hipotansiyon, bir hastada cilt altı ekimoz ve bir hastada kendini sınırlayan iliopsoas hematomu olmak üzere toplam beş (%10) hastada minör komplikasyon izlenmiş olup, hiçbir hastada majör komplikasyon gelişmedi.
Sonuç: BT eşliğinde pelvik kemik biyopsisi, yüksek teknik başarı ve tanısal performans ile güvenli bir yöntemdir. Küçük ve sklerotik lezyonlarda nondiagnostik sonuç olasılığı daha yüksektir.

References

  • Masood S, Mallinson PI, Sheikh A, Ouellette H, Munk PL. Percutaneous bone biopsy. Tech Vasc Interv Radiol 2022;25:100800.
  • Errani C, Traina F, Perna F, Calamelli C, Faldini C. Current concepts in the biopsy of musculoskeletal tumors. ScientificWorldJournal 2013;2013:538152.
  • Meek RD, Mills MK, Hanrahan CJ, et al. Pearls and pitfalls for soft-tissue and bone biopsies: A cross-institutional review. Radiographics 2020;40:266–290.
  • Espinosa LA, Jamadar DA, Jacobson JA, et al. CT-guided biopsy of bone: a radiologist’s perspective. AJR Am J Roentgenol 2008;190:W283–W289.
  • McCarthy EF. CT-guided needle biopsies of bone and soft tissue tumors: a pathologist’s perspective. Skeletal Radiol 2007;36:181–182.
  • Seeger LL. Revisiting tract seeding and compartmental anatomy for percutaneous image-guided musculoskeletal biopsies. Skeletal Radiol 2019;48:499–501.
  • Jelinek J, Buick M, Shmookler B. Image-guided percutaneous biopsies of musculoskeletal lesions. AJR Am J Roentgenol 1996;167:532–533.
  • Shif Y, Kung JW, McMahon CJ, et al. Safety of omitting routine bleeding tests prior to image-guided musculoskeletal core needle biopsy. Skeletal Radiol 2018;47:215–221.
  • Foremny GB, Pretell-Mazzini J, Jose J, Subhawong TK. Risk of bleeding associated with interventional musculoskeletal radiology procedures: A comprehensive review. Skeletal Radiol 2015;44:619–627.
  • Wu JS, Goldsmith JD, Horwich PJ, Shetty SK, Hochman MG. Bone and soft-tissue lesions: factors affecting diagnostic yield of image-guided core-needle biopsy. Radiology 2008;248:962–970.
  • Didolkar MM, Anderson ME, Hochman MG, et al. Image guided core needle biopsy of musculoskeletal lesions: are nondiagnostic results clinically useful? Clin Orthop Relat Res 2013;471:3601–3609.
  • Afonso PD, Weber MA, Isaac A, Bloem JL. Hip and pelvis bone tumors: can you make it simple? Semin Musculoskelet Radiol 2019;23:e37–e57.
  • Girish G, Finlay K, Fessell D, et al. Imaging review of skeletal tumors of the pelvis: malignant tumors and tumor mimics. ScientificWorldJournal 2012;2012:240281.
  • Girish G, Finlay K, Morag Y, et al. Imaging review of skeletal tumors of the pelvis—Part I: benign tumors of the pelvis. ScientificWorldJournal 2012;2012:290930.
  • Bloem JL, Reidsma II. Bone and soft tissue tumors of hip and pelvis. Eur J Radiol 2012;81:3793–3801.
  • Patel IJ, Rahim S, Davidson JC, et al. Society of Interventional Radiology consensus guidelines for the periprocedural management of thrombotic and bleeding risk in patients undergoing percutaneous image-guided interventions—Part II: Recommendations. J Vasc Interv Radiol 2019;30:1168–1184.e1.
  • Davidson JC, Rahim S, Hanks SE, et al. Society of Interventional Radiology consensus guidelines for the periprocedural management of thrombotic and bleeding risk in patients undergoing percutaneous image-guided interventions—Part I: Review of anticoagulation agents and clinical considerations. J Vasc Interv Radiol 2019;30:1155–1167.
  • Moran TC, Kaye AD, Mai AH, Bok LR. Sedation, analgesia, and local anesthesia: a review for general and interventional radiologists. Radiographics 2013;33:E47–E60.
  • Patatas K, Koukkoulli A. The use of sedation in the radiology department. Clin Radiol 2009;64:655–663.
  • Sacks D, McClenny TE, Cardella JF, Lewis CA. Society of Interventional Radiology clinical practice guidelines. J Vasc Interv Radiol 2003;14:S199–S202.
  • Chang IJ, Ilaslan H, Sundaram M, Schils J, Subhas N. CT-guided percutaneous biopsy of sclerotic bone lesions: diagnostic outcomes. Skeletal Radiol 2018;47:661–669.
  • Spinnato P, Colangeli M, Rinaldi R, Ponti F. Percutaneous CT-guided bone biopsies: indications, feasibility and diagnostic yield in the different skeletal sites—from the skull to the toe. Diagnostics (Basel) 2023;13:2350.
  • Donners R, Fotiadis N, Figueiredo I, et al. Optimising CT-guided biopsies of sclerotic bone lesions in cancer patients. Eur Radiol 2022;32:6820–6829.
  • Sung KS, Seo SW, Shon MS. The diagnostic value of needle biopsy for musculoskeletal lesions. Int Orthop 2009;33:1701–1706.
  • Cohen MG, McMahon CJ, Kung JW, Wu JS. Comparison of battery-powered and manual bone biopsy systems for core needle biopsy of sclerotic bone lesions. AJR Am J Roentgenol 2016;206:W83–W86.
  • Goode EA, Wang N, Munkley J. Prostate cancer bone metastases: biology and clinical management. Oncol Lett 2023;25:163.
  • O’Sullivan GJ, Carty FL, Cronin CG. Imaging of bone metastasis: an update. World J Radiol 2015;7:202–211.
  • Kattapuram SV, Rosenthal DI. Percutaneous biopsy of skeletal lesions. AJR Am J Roentgenol 1991;157:935–942.

Computed Tomography-guided Percutaneous Pelvic Bone Biopsy: Technical Success, Diagnostic Performance, and Safety

Year 2025, Volume: 7 Issue: 3, 369 - 378, 13.10.2025
https://doi.org/10.52827/hititmedj.1687115

Abstract

Objective: To evaluate the technical success, diagnostic performance, and complications of CT-guided pelvic bone biopsies.
Material and Method: Fifty patients (32 women, 18 men; mean age: 57.5 ± 15.5 years; range: 20–91) who underwent CT-guided pelvic bone biopsy (sacrum, ilium, ischium, pubis, proximal femur) between 2017 and 2024 were included. Biopsies were performed by interventional radiologists with a minimum of five years of experience. Lesion size, location, type (lytic, sclerotic, or mixed), pathology results, technical success, diagnostic performance, and complications were recorded from patient files and the Picture Archiving and Communication System (PACS). Complications were classified as minor or major according to the Society of Interventional Radiology (SIR) guidelines.
Results: Technical success was 100% (50/50). Pathology revealed malignancy in 25 (50%) patients, benignity in 15 (30%), and nondiagnostic results in 10 (20%), yielding a diagnostic performance of 80%. Nondiagnostic lesions were significantly smaller than malignant (p=0.002) and benign (p<0.001) ones. Lesion types were lytic in 16 (32%), sclerotic in 17 (34%), and mixed in 17 (34%) cases. When pathology results were grouped as diagnostic (malignant or benign) vs. nondiagnostic, a significant association was found with lesion type (p=0.025); 70% of nondiagnostic lesions were sclerotic. Minor complications occurred in 5 (10%) patients, including moderate pain (n=2), transient hypotension (n=1), ecchymosis (n=1), and localized iliopsoas hematoma (n=1). No major complications were observed.
Conclusion: CT-guided pelvic bone biopsy is a safe procedure with high technical success and diagnostic yield. Smaller and sclerotic lesions are more likely to result in nondiagnostic outcomes.

References

  • Masood S, Mallinson PI, Sheikh A, Ouellette H, Munk PL. Percutaneous bone biopsy. Tech Vasc Interv Radiol 2022;25:100800.
  • Errani C, Traina F, Perna F, Calamelli C, Faldini C. Current concepts in the biopsy of musculoskeletal tumors. ScientificWorldJournal 2013;2013:538152.
  • Meek RD, Mills MK, Hanrahan CJ, et al. Pearls and pitfalls for soft-tissue and bone biopsies: A cross-institutional review. Radiographics 2020;40:266–290.
  • Espinosa LA, Jamadar DA, Jacobson JA, et al. CT-guided biopsy of bone: a radiologist’s perspective. AJR Am J Roentgenol 2008;190:W283–W289.
  • McCarthy EF. CT-guided needle biopsies of bone and soft tissue tumors: a pathologist’s perspective. Skeletal Radiol 2007;36:181–182.
  • Seeger LL. Revisiting tract seeding and compartmental anatomy for percutaneous image-guided musculoskeletal biopsies. Skeletal Radiol 2019;48:499–501.
  • Jelinek J, Buick M, Shmookler B. Image-guided percutaneous biopsies of musculoskeletal lesions. AJR Am J Roentgenol 1996;167:532–533.
  • Shif Y, Kung JW, McMahon CJ, et al. Safety of omitting routine bleeding tests prior to image-guided musculoskeletal core needle biopsy. Skeletal Radiol 2018;47:215–221.
  • Foremny GB, Pretell-Mazzini J, Jose J, Subhawong TK. Risk of bleeding associated with interventional musculoskeletal radiology procedures: A comprehensive review. Skeletal Radiol 2015;44:619–627.
  • Wu JS, Goldsmith JD, Horwich PJ, Shetty SK, Hochman MG. Bone and soft-tissue lesions: factors affecting diagnostic yield of image-guided core-needle biopsy. Radiology 2008;248:962–970.
  • Didolkar MM, Anderson ME, Hochman MG, et al. Image guided core needle biopsy of musculoskeletal lesions: are nondiagnostic results clinically useful? Clin Orthop Relat Res 2013;471:3601–3609.
  • Afonso PD, Weber MA, Isaac A, Bloem JL. Hip and pelvis bone tumors: can you make it simple? Semin Musculoskelet Radiol 2019;23:e37–e57.
  • Girish G, Finlay K, Fessell D, et al. Imaging review of skeletal tumors of the pelvis: malignant tumors and tumor mimics. ScientificWorldJournal 2012;2012:240281.
  • Girish G, Finlay K, Morag Y, et al. Imaging review of skeletal tumors of the pelvis—Part I: benign tumors of the pelvis. ScientificWorldJournal 2012;2012:290930.
  • Bloem JL, Reidsma II. Bone and soft tissue tumors of hip and pelvis. Eur J Radiol 2012;81:3793–3801.
  • Patel IJ, Rahim S, Davidson JC, et al. Society of Interventional Radiology consensus guidelines for the periprocedural management of thrombotic and bleeding risk in patients undergoing percutaneous image-guided interventions—Part II: Recommendations. J Vasc Interv Radiol 2019;30:1168–1184.e1.
  • Davidson JC, Rahim S, Hanks SE, et al. Society of Interventional Radiology consensus guidelines for the periprocedural management of thrombotic and bleeding risk in patients undergoing percutaneous image-guided interventions—Part I: Review of anticoagulation agents and clinical considerations. J Vasc Interv Radiol 2019;30:1155–1167.
  • Moran TC, Kaye AD, Mai AH, Bok LR. Sedation, analgesia, and local anesthesia: a review for general and interventional radiologists. Radiographics 2013;33:E47–E60.
  • Patatas K, Koukkoulli A. The use of sedation in the radiology department. Clin Radiol 2009;64:655–663.
  • Sacks D, McClenny TE, Cardella JF, Lewis CA. Society of Interventional Radiology clinical practice guidelines. J Vasc Interv Radiol 2003;14:S199–S202.
  • Chang IJ, Ilaslan H, Sundaram M, Schils J, Subhas N. CT-guided percutaneous biopsy of sclerotic bone lesions: diagnostic outcomes. Skeletal Radiol 2018;47:661–669.
  • Spinnato P, Colangeli M, Rinaldi R, Ponti F. Percutaneous CT-guided bone biopsies: indications, feasibility and diagnostic yield in the different skeletal sites—from the skull to the toe. Diagnostics (Basel) 2023;13:2350.
  • Donners R, Fotiadis N, Figueiredo I, et al. Optimising CT-guided biopsies of sclerotic bone lesions in cancer patients. Eur Radiol 2022;32:6820–6829.
  • Sung KS, Seo SW, Shon MS. The diagnostic value of needle biopsy for musculoskeletal lesions. Int Orthop 2009;33:1701–1706.
  • Cohen MG, McMahon CJ, Kung JW, Wu JS. Comparison of battery-powered and manual bone biopsy systems for core needle biopsy of sclerotic bone lesions. AJR Am J Roentgenol 2016;206:W83–W86.
  • Goode EA, Wang N, Munkley J. Prostate cancer bone metastases: biology and clinical management. Oncol Lett 2023;25:163.
  • O’Sullivan GJ, Carty FL, Cronin CG. Imaging of bone metastasis: an update. World J Radiol 2015;7:202–211.
  • Kattapuram SV, Rosenthal DI. Percutaneous biopsy of skeletal lesions. AJR Am J Roentgenol 1991;157:935–942.
There are 28 citations in total.

Details

Primary Language English
Subjects Radiology and Organ Imaging
Journal Section Research Articles
Authors

Kadir Han Alver 0000-0002-4692-2401

Muhammet Arslan 0000-0001-5565-0770

Publication Date October 13, 2025
Submission Date April 29, 2025
Acceptance Date July 18, 2025
Published in Issue Year 2025 Volume: 7 Issue: 3

Cite

AMA Alver KH, Arslan M. Computed Tomography-guided Percutaneous Pelvic Bone Biopsy: Technical Success, Diagnostic Performance, and Safety. Hitit Medical Journal. October 2025;7(3):369-378. doi:10.52827/hititmedj.1687115