Hastalıkların Tedavisinde Umut Vadeden Yeni Hedef: FOXO Transkripsiyon Faktörleri

Yıl 2022, Cilt: 2 Sayı: 1, 25 - 32, 03.04.2022

Nihal Vuranok

https://doi.org/10.29228/HMJ.11

Öz

Hücreler, hayatta kalmak veya apoptozun hücresel cevabını koordine edebilmek için ayrıntılı mekanizmalar geliştirmiştir. Forkhead box-O transkripsiyon faktörleri (FOXO); DNA hasar onarımı, hücre döngüsü ilerlemesi ve durdurulması, oksidatif stres tepkisi ve redoks sinyali, glukoneogenez ve apoptoz ile ilgili genlerin ekspresyonunu düzenleyerek çeşitli hücresel süreçlerin yürütülmesinde kritik rol oynamaktadır. FOXO transkripsiyon faktörlerinin fonksiyonu; fosforilasyon, asetilasyon ve ubiküitinasyon gibi translasyon sonrası modifikasyonlar ve nükleer sitoplazmik geçiş ile sıkı bir şekilde kontrol edilmektedir. Yapılan çalışmalar; FOXO aktivitesinin düzenleyici etkisinin, oksidatif stres dahil olmak üzere farklı uyaranlara yanıt olarak oluştuğunu göstermektedir. FOXO transkripsiyon faktörlerinin transkripsiyon sonrası modifikasyonundaki anormallikler sıklıkla çeşitli hastalık durumlarıyla bağlantılıdır. Bu çalışmada, bilim insanlarına yeni araştırma fikirleri sunmak amacıyla FOXO transkripsiyon faktörleri’ nin tanımı ve sınıflandırılması, oksidatif stres ve kanser dahil olmak üzere çeşitli fizyolojik ve patofizyolojik koşullar altında transkripsiyon sonrası FOXO modifikasyonları ve FOXO' ların tümör baskılayıcı özelliklerinin terapötik olarak klinik kullanımı literatür bilgisi ışığında araştırılarak derlendi.

Anahtar Kelimeler

FOXO, HASTALIK, İLAÇ, TRANSKRİPSİYON FAKTÖRLERİ

Promising New Target in the Treatment of Diseases: FOXO Transcription Factors

Öz

Cells have evolved elaborate mechanisms to survive or coordinate the cellular response to apoptosis. Forkhead box-O transcription factors (FOXOs); It plays critical roles in the execution of various cellular processes by regulating the expression of genes involved in DNA damage repair, cell cycle progression and arrest, oxidative stress response and redox signaling, gluconeogenesis and apoptosis. Function of FOXO transcription factors; It is tightly controlled by post-translational modifications such as phosphorylation, acetylation and ubiquitination, and nuclear cytoplasmic transition. Made works; It shows that the regulatory effect of FOXO activity occurs in response to different stimuli, including oxidative stress. Abnormalities in post-transcriptional modification of FOXO transcription factors are frequently associated with various disease states. In this study; In order to present new research ideas to scientists, the definition and classification of FOXO transcription factors, post-transcriptional FOXO modifications under various physiological and pathophysiological conditions, including oxidative stress and cancer, and the clinical use of FOXO's tumor suppressor properties as therapeutics were investigated and compiled in the light of literature.

Anahtar Kelimeler

DISEASE, FOXO, MEDICINE, TRANSCRIPTION FACTORS

Kaynakça

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