Research Article
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Gastrointestinal sistemde kanama, perforasyon ve fistüllerde endoskopik klip uygulamaları etkinliği : Tek merkez deneyimi

Year 2023, Volume: 3 Issue: 2, 48 - 53, 21.08.2023
https://doi.org/10.58961/hmj.1315679

Abstract

Amaç: Gastrointestinalsistem kanamaları, perforasyonları ve fistülleri sık karşılaşılan durumlar olmakla birlikte minimal invaziv işlem olarak görülen endoskopik işlemler ile tedavi edilebilmektedir. Over thescope kliplerin (OTSC) kullanıma girmesi ile birlikte işlem başarısı artmakta ve tedavi modalitelerinde ilk basamak olarak kullanımı önerilmektedir. Bu çalışma da literatüre katkı vermeyi ve deneyimlerimizi paylaşmayı amaçlamaktadır.
Çalışma Planı: Kliniğimizde 2020 ile 2023 yılları arasında gastrointestinal sistem perforasyonları, anastomozkaçakları, fistülleri,kanamaları ve endomukozal rezeksiyon sonrası endoskopik klip uygulaması yapılan 21 hasta değerlendirildi.
Bulgular: Çalışmamıza 13 erkek (%61,9) olmak üzere toplam 21 hasta dahil edildi. Kanama grubunda 16, anatomoz kaçağı grubunda bir, fistül grubunda bir, endomukozal rezeksiyon grubunda üç hasta vardı.Kanama grubundahiçbir hastada başarısızlık görülmedi. Antitrombotik ilaç kullanımı başarıyı değiştirmemekteydi. Cerrahi işlem gerekliliği olmadı. 30 günlük takipte ise sadece bir hastada(%6,25) tekrar kanama ve yeniden işlem gerekliliği oldu. Endomukozal rezeksiyon, fistül ve anastomoz kaçağında uygulanan kliplerin işlemlerinde herhangi bir komplikasyon takibimizde saptanmadı. Uygulanan eritrosit süspansiyonu replasmanı ile hastanede yatış süresi arasında pozitif yönde korelasyon mevcuttu (p<0.001; p=0,897). Ancak kullanılan klip sayısı ile hastanede yatış süresi arasında anlamlı ilişki saptanmadı (p=0,451).
Sonuç: Alt ve üst gastrointestinal sistem kanamalarında, anastomoz kaçaklarında, fistüllerinde ve endomukozal rezeksiyon sonrası perforasyonlarda over the scope kliplerin kullanımı güvenli ve başarılıdır.

References

  • Wedi E, Fischer A, Hochberger J, Jung C, Orkut S, Richter-Schrag HJ. Multi center evaluation of first-line endoscopic treatment with the OTSC in acute non-variceal upper gastrointestinal bleeding and comparisonwith the Rockall cohort: the FLET Rock study. SurgEndosc.2018;32(1):307-314.
  • Dişibeyaz S, Köksal AŞ, Parlak E, Torun S, Şaşmaz N. Endoscopic closure of gastrointestinal defects with an over-the-scope clip device. A case series and review of the literature. ClinResHepatolGastroenterol.2012;36(6):614-621.
  • Surace M, Mercky P, Demarquay JF, et al. Endoscopic management of GI fistulae with the over-the-scope clip system (with video).GastrointestEndosc. 2011;74(6):1416-1419.
  • Buttar NS, Chesta F, Martin JA. Silencing the Erupter: Over-the-Scope Clip in the Management of Non variceal Upper GastrointestinalBleeding. ClinGastroenterolHepatol. 2021;19(11):2266-2269.
  • Brandler J, Baruah A, Zeb M, et al. Efficacy of Over-the-Scope Clips in Management of High-Risk Gastrointestinal Bleeding.ClinGastroenterolHepatol. 2018;16(5):690-696.e1.
  • Barkun AN, Almadi M, Kuipers EJ, et al. Management of Non variceal Upper Gastrointestinal Bleeding: Guideline Recommendations From the International Consensus Group. AnnInternMed. 2019;171(11):805-822.
  • Jensen DM, Kovacs T, Ghassemi KA, Kaneshiro M, Gornbein J.Randomized Controlled Trial of Over-the-Scope Clip as InitialTreatment of Severe Non variceal Upper Gastrointestinal Bleeding.ClinGastroenterolHepatol. 2021;19(11):2315-2323.e2.
  • Asokkumar R, Soetikno R, Sanchez-Yague A, Kim Wei L, Salazar E, Ngu JH. Use of over-the-scope-clip (OTSC) improves outcomes of high-risk adverse outcome (HR-AO) non-variceal upper gastrointestinal bleeding (NVUGIB). EndoscInt Open. 2018;6(7):E789-E796.
  • Arezzo A, Verra M, Reddavid R, Cravero F, Bonino MA, Morino M. Efficacy of the over-the-scopeclip (OTSC) for treatment of colorectal post surgical leaks and fistulas. SurgEndosc. 2012;26(11):3330-3333.
  • Sandmann M, Heike M, Faehndrich M. Application of the OTSC system for the closure of fistulas, anastomosal leakages and perforations within the gastrointestinal tract. Z Gastroenterol. 2011;49(8):981-985.
  • Akay T, Leblebici M. Comparison of high and low-dose epinephrine & endoclip application in peptic ulcer bleeding: A case series analysisobservational study. Medicine (Baltimore). 2021;100(52):e28480.
  • Kayano H, Nomura E, Ueda Y, et al. Short-term outcomes of OTSC for anastomotic leakage after laparoscopic colorectal surgery. MinimInvasiveTherAlliedTechnol. 2021;30(6):369-376.
  • Kähler G, Kouladouros K. Endoskopisches Komplikations management am oberenundunteren Gastrointestinal trakt [Endoscopic management of complications of the upper and lower gastrointestinal tract]. Chirurgie(Heidelb). 2023;94(4):382-390.
  • Mennigen R, Colombo-Benkmann M, Senninger N, Laukoetter M.Endoscopic closure of postoperative gastrointestinal leakages and fistulas with the Over-the-Scope Clip (OTSC). J GastrointestSurg.2013;17(6):1058-1065.
  • Meier B, Wannhoff A, Denzer U, et al. Over-the-scope-clips versusstandard treatment in high-risk patients with- acute non-variceal upper gastrointestinal bleeding: a randomised controlled trial (STING-2). Gut. 2022;71(7):1251-1258.
  • Triantafyllou K, Gkolfakis P, Gralnek IM, et al. Diagnosis andmanagement of acute lower gastrointestinal bleeding: European Society of Gastrointestinal Endoscopy (ESGE) Guideline [published correctionappears in Endoscopy. 2021 Jun17;:]. Endoscopy. 2021;53(8):850-868.
  • Lamberts R, Koch A, Binner C, et al. Use of over-the-scopeclips (OTSC) for hemostasis in gastrointestinal bleeding in patients underantithrombotictherapy. EndoscInt Open. 2017;5(5):E324-E330.
  • Weiland T, Rohrer S, Schmidt A, et al. Efficacy of the OTSC System in the treatment of GI bleeding and Wall defects: a PMCF meta-analysis. Minim InvasiveTherAlliedTechnol. 2020;29(3):121-139.

Efficacy of the endoscopic clip method in patients treated with the endoscopic clip method for gastrointestinal bleeding, perforations and fistulas : One Center Experience

Year 2023, Volume: 3 Issue: 2, 48 - 53, 21.08.2023
https://doi.org/10.58961/hmj.1315679

Abstract

Introduction:Gastrointestinal bleeding, perforations and fistulas are common conditions and can betreated with endoscopic procedures that are considered as minimally invasive procedures. With theintroduction of ovarian thescope clips (OTSC), the success of the procedure is increasing and its use isrecommended as the first step in treatment modalities. This study aims to contribute to the literatüre and share our experiences.
Methods:Between 2020 and 2023, 21 patients who underwent endoscopic clipapplication after gastrointestinal tract perforations, anastomotic leaks, fistulas, bleeding andendomucosal resection in our clinic were evaluated.
Results:A total of 21 patients, 13 males (61.9%), were included in our study. There were 16 patientsin the bleeding group, one in the anatomical leak group, one in the fistula group and three in theendomucosal resection group. No failure was seen in any patient in the bleeding group.Antithrombotic drug use did not change the success. No surgical procedure was required. At 30-dayfollow-up, only one patient (6.25%) had rebleeding and required reoperation. No complications weredetected in the procedures of endomucosal resection, fistula and clips applied in anastomotic leakage.There was a positive correlation between erythrocyte suspension replacement and length ofhospitalization (p<0.001; p=0.897). However, there was no significant correlation between thenumber of clips used and the duration of hospitalization (p=0.451).
Conclusion:The use of over the scope clips is safe and successful in upper and lower gastrointestinaltract bleeding, gastrointestinal tract anastomotic leaks, fistulas and perforations after endomucosalresection.

References

  • Wedi E, Fischer A, Hochberger J, Jung C, Orkut S, Richter-Schrag HJ. Multi center evaluation of first-line endoscopic treatment with the OTSC in acute non-variceal upper gastrointestinal bleeding and comparisonwith the Rockall cohort: the FLET Rock study. SurgEndosc.2018;32(1):307-314.
  • Dişibeyaz S, Köksal AŞ, Parlak E, Torun S, Şaşmaz N. Endoscopic closure of gastrointestinal defects with an over-the-scope clip device. A case series and review of the literature. ClinResHepatolGastroenterol.2012;36(6):614-621.
  • Surace M, Mercky P, Demarquay JF, et al. Endoscopic management of GI fistulae with the over-the-scope clip system (with video).GastrointestEndosc. 2011;74(6):1416-1419.
  • Buttar NS, Chesta F, Martin JA. Silencing the Erupter: Over-the-Scope Clip in the Management of Non variceal Upper GastrointestinalBleeding. ClinGastroenterolHepatol. 2021;19(11):2266-2269.
  • Brandler J, Baruah A, Zeb M, et al. Efficacy of Over-the-Scope Clips in Management of High-Risk Gastrointestinal Bleeding.ClinGastroenterolHepatol. 2018;16(5):690-696.e1.
  • Barkun AN, Almadi M, Kuipers EJ, et al. Management of Non variceal Upper Gastrointestinal Bleeding: Guideline Recommendations From the International Consensus Group. AnnInternMed. 2019;171(11):805-822.
  • Jensen DM, Kovacs T, Ghassemi KA, Kaneshiro M, Gornbein J.Randomized Controlled Trial of Over-the-Scope Clip as InitialTreatment of Severe Non variceal Upper Gastrointestinal Bleeding.ClinGastroenterolHepatol. 2021;19(11):2315-2323.e2.
  • Asokkumar R, Soetikno R, Sanchez-Yague A, Kim Wei L, Salazar E, Ngu JH. Use of over-the-scope-clip (OTSC) improves outcomes of high-risk adverse outcome (HR-AO) non-variceal upper gastrointestinal bleeding (NVUGIB). EndoscInt Open. 2018;6(7):E789-E796.
  • Arezzo A, Verra M, Reddavid R, Cravero F, Bonino MA, Morino M. Efficacy of the over-the-scopeclip (OTSC) for treatment of colorectal post surgical leaks and fistulas. SurgEndosc. 2012;26(11):3330-3333.
  • Sandmann M, Heike M, Faehndrich M. Application of the OTSC system for the closure of fistulas, anastomosal leakages and perforations within the gastrointestinal tract. Z Gastroenterol. 2011;49(8):981-985.
  • Akay T, Leblebici M. Comparison of high and low-dose epinephrine & endoclip application in peptic ulcer bleeding: A case series analysisobservational study. Medicine (Baltimore). 2021;100(52):e28480.
  • Kayano H, Nomura E, Ueda Y, et al. Short-term outcomes of OTSC for anastomotic leakage after laparoscopic colorectal surgery. MinimInvasiveTherAlliedTechnol. 2021;30(6):369-376.
  • Kähler G, Kouladouros K. Endoskopisches Komplikations management am oberenundunteren Gastrointestinal trakt [Endoscopic management of complications of the upper and lower gastrointestinal tract]. Chirurgie(Heidelb). 2023;94(4):382-390.
  • Mennigen R, Colombo-Benkmann M, Senninger N, Laukoetter M.Endoscopic closure of postoperative gastrointestinal leakages and fistulas with the Over-the-Scope Clip (OTSC). J GastrointestSurg.2013;17(6):1058-1065.
  • Meier B, Wannhoff A, Denzer U, et al. Over-the-scope-clips versusstandard treatment in high-risk patients with- acute non-variceal upper gastrointestinal bleeding: a randomised controlled trial (STING-2). Gut. 2022;71(7):1251-1258.
  • Triantafyllou K, Gkolfakis P, Gralnek IM, et al. Diagnosis andmanagement of acute lower gastrointestinal bleeding: European Society of Gastrointestinal Endoscopy (ESGE) Guideline [published correctionappears in Endoscopy. 2021 Jun17;:]. Endoscopy. 2021;53(8):850-868.
  • Lamberts R, Koch A, Binner C, et al. Use of over-the-scopeclips (OTSC) for hemostasis in gastrointestinal bleeding in patients underantithrombotictherapy. EndoscInt Open. 2017;5(5):E324-E330.
  • Weiland T, Rohrer S, Schmidt A, et al. Efficacy of the OTSC System in the treatment of GI bleeding and Wall defects: a PMCF meta-analysis. Minim InvasiveTherAlliedTechnol. 2020;29(3):121-139.
There are 18 citations in total.

Details

Primary Language English
Subjects Surgery (Other)
Journal Section Research Articles
Authors

Alpaslan Fedayi Çalta 0000-0001-8372-0991

Publication Date August 21, 2023
Submission Date June 16, 2023
Published in Issue Year 2023 Volume: 3 Issue: 2

Cite

Vancouver Çalta AF. Efficacy of the endoscopic clip method in patients treated with the endoscopic clip method for gastrointestinal bleeding, perforations and fistulas : One Center Experience. HMJ. 2023;3(2):48-53.

e-ISSN: 2791-9935