Polypharmacy and drug-drug interactions among patients with Diabetes Mellitus

Year 2023, Volume: 3 Issue: 3, 7 - 15, 22.12.2023

Filiz Özyiğit , Türkan Paşalı Kilit , Kevser Onbaşı

https://doi.org/10.58961/hmj.1394987

Abstract

Background: Diabetes mellitus is a chronic disease. The aim of our study was to evaluate drug- drug interactions and polypharmacy in diabetic patients.
Methods: Patients with type 2 diabetes attending our internal medicine and endocrinology policlinics from April 2019 to July 2019 were included to the study. It was designed as a prospective, descriptive and cross-sectional study. The socio-demographic characteristics of diabetic individuals, the drugs they use in the treatment of diabetes, and other accompanying diseases were evaluated according to the ATC classification. In this study, interactions between multiple drugs and polypharmacy were examined.
Results: The study population consisted of 526 patients between the ages of 18-87/years (59 ± 11). 69.6% of the patients were women.83.8% of the patients had chronic diseases accompanying diabetes. The most common chronic diseases were hypertension (53.6%), hyperlipidemia (41.4%) and coronary artery disease (27.2%), respectively. 45.01% of the patients were using five or more drugs. The mean number of drugs was found to be 4.49 ± 1.93. Among the drugs used by the patients, 787 drug-drug interactions were found in a total of 429 (81.5%) patients. The average number of interactions was 3.89 ± 3.6 for interaction A 15.2% (n = 81), 16.2% (n = 85) for interaction B, 69.8% (n = 367) for interaction C was, 47.9% (n = 252) for interaction D, and 0.4% (n = 2) for interaction X. The most frequent interaction was found between acetylsalicylic acid and insulin and metformin and angiotensin converting enzyme inhibitors.
Conclusions: Both the polypharmacy rate and drug-drug interaction rate are high in diabetic patients. The most common type of interaction is type C and type D drug-drug interaction. Attention should be paid to drug-drug interactions in the treatment of diabetes patients.

Keywords

drug-drug interactions, polypharmacy, diabetes

Diabet hastalarında polifarmasi ve ilaç ilaç etkileşimleri

Abstract

Amaç: Diabetes Mellitus kronik bir hastalıktır. Çalışmamızın amacı diyabetik hastalarda ilaç-ilaç etkileşimlerini ve polifarmasiyi değerlendirmektir.
Yöntemler: Nisan 2019 ile Temmuz 2019 tarihleri arasında dahiliye ve endokrinoloji polikliniğimize başvuran tip 2 diyabetli hastalar çalışmaya dahil edildi. Prospektif, tanımlayıcı ve kesitsel bir çalışma olarak tasarlandı. Diyabetli bireylerin sosyo-demografik özellikleri, diyabet tedavisinde kullandıkları ilaçlar ve eşlik eden diğer hastalıkları ATC sınıflamasına göre değerlendirildi. Bu çalışmada çoklu ilaç ve polifarmasi arasındaki etkileşimler incelenmiştir.
Sonuçlar
Araştırmanın evrenini yaşları 18-87/yıl (59±11) arasında değişen 526 hasta oluşturdu. Hastaların %69,6'sı kadındı. Hastaların %83,8'inde diyabete eşlik eden kronik hastalıklar vardı. En sık görülen kronik hastalıklar sırasıyla hipertansiyon (%53,6), hiperlipidemi (%41,4) ve koroner arter hastalığı (%27,2) olarak belirlendi. Hastaların %45,01'i beş ve daha fazla ilaç kullanıyordu. Ortalama ilaç sayısı ise 4,49±1,93 olarak belirlendi. Hastaların kullandığı ilaçlardan toplam 429 (%81,5) hastada 787 ilaç-ilaç etkileşimi tespit edildi. Ortalama etkileşim sayısı 3,89 ± 3,6, etkileşim A için %15,2 (n = 81), etkileşim B için %16,2 (n = 85), etkileşim C için %69,8 (n = 367), %47,9 (n = 252) idi. etkileşim D için ve etkileşim X için %0,4 (n = 2). En sık görülen etkileşim asetilsalisilik asit ve insülin ile metformin ve anjiyotensin dönüştürücü enzim inhibitörleri arasında bulundu.
Diyabetik hastalarda hem polifarmasi oranı hem de ilaç-ilaç etkileşimi oranı yüksektir. En sık görülen etkileşim türü C tipi ve D tipi ilaç-ilaç etkileşimleridir. Diyabet hastalarının tedavisinde ilaç-ilaç etkileşimlerine dikkat edilmelidir.

Keywords

Diabetes Mellitus, İlaç ilaç etkileşimleri, polifarmasi

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