YENİ S-İKAME EDİLMİŞ BIS-1,2,4-TRİAZOLLERİN SENTEZİ VE FİZİKSEL KİMYASAL ÖZELLİKLERİ

Year 2021, Volume: 41 Issue: 3, 150 - 161, 01.09.2021

Yevhen Karpun

https://doi.org/10.52794/hujpharm.973420

Cited By: 2

Abstract

Özet. Çalışmanın amacı, bir molekülde iki 1,2,4-triazol sistemini birleştirme yöntemini, daha önce keşfedilmemiş 1,2,4-triazolün S-türevlerini elde etmek için tiyol grubunun alkilasyon reaksiyonunu ve gaz kromatografisi-kütle spektrometrisi kullanılarak sert iyonizasyon altındaki maddelerin parçalanma yolu. Sentezlenen bileşiklerin yapıları element analizi, 1H ve 13C NMR spektroskopisi ve GC-MS analizi ile doğrulandı. S-alkil tortuları için karakteristik sinyaller, alifatik bileşikler için tipik olan bölgede gözlendi. Moleküllerin parçalanması, radikallerin kademeli olarak bölünmesi ve ikinci 1,2,4-triazol heterosiklinin açılması ile temsil edildi.

Keywords

heterosiklik bileşik, sentez, parçalanma yolu., 1,2,4-triazol

Synthesis, Structure and Properties of Novel S-Substituted BIS-1,2,4-Triazoles

Abstract

The aim of the work was to describe the method of combining two 1,2,4-triazole systems in a molecule, the alkylation reaction of the thiol group to obtain the previ- ously undiscovered S-derivatives of 1,2,4-triazole and the fragmentation pathway of the substances under hard ionization using gas chromatography-mass spectrom- etry. The structures of the synthesized compounds were confirmed by elemental analysis, 1H and 13C NMR spectroscopy and GC-MS analysis. The characteristic signals for S-alkyl residues were observed in the region typical for aliphatic com- pounds. The fragmentation of molecules was represented by the gradual cleavage of radicals and the opening of the second 1,2,4-triazole heterocycle.

Keywords

Keywords: 1, heterocyclic compound, synthesis, fragmentation pathway, 1,2,4-triazole

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