Randomize Kontrollü Deneyler

Year 2017, Volume: 4 Issue: 1, 73 - 92, 18.05.2017

Belgin Akın , Deniz Koçoğlu

Abstract

Bu derleme kanıta dayalı uygulama bakış açısının gelişmesiyle birlikte önemli bir araştırma türü haline gelen Randomize Kontrollü Deneylerle ilgili temel kavram ve yaklaşımların açıklanması amacıyla yapılmıştır. Randomize Kontrollü Deneylerin başarısı ve kalitesi ölçülen sonucun ortaya çıkmasında uygulanan müdahalenin gerçek etkisinin gösterilmesine bağlıdır. Bu neden-sonuç bağlantısının kurulması Randomize Kontrollü Deneylerin bir protokol çerçevesinde yürütülmesi, random atamanın yapılması, yanlılıkların önlenmesi, iç ve dış geçerliliğin sağlanması, körleme tekniklerinin kullanılması ve uygun istatistiksel değerlendirmenin yapılmasıyla olasıdır. Bu derleme bu aşamalara ilişkin yapılan hataları ve alınabilecek önlemlere ilişkin yaklaşımları içermektedir.

Keywords

Dış geçerlik, iç geçerlik, nedensellik, randomize kontrollü deneyler, yanlılık

Randomized Controlled Trials

Abstract

This review aims to explain the basic concepts and approaches related to randomized controlled trials, which is an important type of research with the development of viewpoint of evidence -based care. The success and quality of randomized controlled trials hinge upon observing the actual effect of the applied intervention on the emergence of the measured result. Establishing this cause-effect relation can be possible if randomized controlled trials are conducted within a protocol, use random assignment, avoid biase, ensure internal and external validity, use blind techniques and appropriate statistical evaluations. This review includes the mistakes made in these stages and the precaution to be taken.

Keywords

Bias, causality, external validity, internal validity, randomized controlled trial

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