Cerrahi Kanserli Hastalarda İmmünonütrisyonun Etkinliği

Year 2016, Volume 3, Issue 3, 1 - 16, 31.12.2016

Pelin POLAT M. Merve TENGİLLİMOĞLU METİN Mevlüde Kızıl

Abstract

İmmünonütrisyon olarak adlandırılan arjinin, glutamin, omega-3 yağ asitleri ve nükleotidlerle zenginleştirilen enteral diyet, cerrahi sonrası hastanede kalış süresini, infeksiyöz komplikasyon ve morbidite riskini azaltmaktadır. Bu nütrientler inflamatuar yanıtı, bağırsak ve immün fonksiyonları düzenlemektedir. İmmün sistem, patojen mikroorganizmalara ve kanser hücrelerine karşı birincil savunmadır. Proinflamuar sitokinlerin salınması, reaktif oksijen nitrojen türlerinin oluşumu inflamatuar yanıt için gereklidir. İmmün sistemin diyet bileşenleri ile güçlendirilerek regüle edilmesi kanser hastalarında önemli bir ek tedavi olarak kabul edilmeye başlanmıştır. Travma veya yanık gibi ciddi hastalıklarda immünonütrientlerin olumlu etkilerini gösteren randomize kontrollü çalışmalar olmasına rağmen kanser hastalarında bu etkileri gösteren güçlü kanıtlar yoktur. Kanser hastalarında immüonütrisyonun faydalı etkilerini gösterebilmek için daha çok prospektif çalışmaya ihtiyaç vardır. Bu derlemede kanserli hastalarda immunonütrisyon desteğinin etkinliği değerlendiren çalışmalar özetlenmiştir.

Keywords

immunonütrient, immunonütrisyon, kanser

Efficiency of Immunonutrition in Surgical Cancer Patients

Abstract

 

The enteral diet enriched with arginine, glutamine, omega-3 fatty acids and nucleotides named as immunonutrition reduce the duration of hospital stay after surgery, infectious complications and the risk of morbidity. These nutrients modulate inflammatory response, intestinal and immunological functions. The immune system is the primary defense against pathogenic microorganisms and cancer cells. The release of proinflammatory cytokines, the formation of reactive oxygen nitrogen species are required for the inflammatory response. Regulation of the immune system with dietary components has become as an important additional therapy in cancer patients. Although there are randomized controlled trials showing positive effects of immunonutrients in serious diseases such as trauma or burn, there is no strong evidence for these effects in cancer patients. Further prospective studies are needed to demonstrate beneficial effects of immunonutrition in cancer patients. In this review, studies evaluating the efficacy of immunonutrition in cancer patients are summarized.

Keywords

immunonutrient, immunonutrition, cancer

References

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