Could RDW and MPV Be a Predictor of Disease Severity and Mortality in Acute Pancreatitis?

Abstract

Background: Background: In acute pancreatitis (AP), determining the severity of the disease starting from hospitalization is important for planning the treatment. Data obtained in previous studies that examining the clinical importance of RDW (Erythrocyte Distribution Volume) and MPV (Mean Plate-let Volume) levels in patients with AP are contradictory. Our aim in this study is to determine whether RDW and MPV levels can predict the severity of pancreatitis and related mortality. Materials and Methods: The data of 262 patients hospitalized due to AP between 2019 and 2022 were retrospectively examined. Patients were divided into groups according to Atlanta crite-ria.Then, the relationship between RDW and MPV values and the severity and prognosis of pancrea-titis was examined statistically. Results: While 83.9% (n=220) of the patients had mild pancreatitis, 16.1% (n=42) had severe pan-creatitis. While the mean RDW index was 42.5±6.9 fL in patients with mild AP, it was 42.0±6.6 fL in severe AP patients and there was no significant difference between the two groups (p=0.625). In addition, there was no significant difference between the two groups in terms of mean MPV level (9.7±1.0 fL vs 9.8±1.3 Fl, p=0.687). ROC analysis showed that there was no significant and critical MPV and RDW threshold value to detect the severity of pancreatitis (AUC values: 0.499 and 0.453, respectively). Conclusions: In our study, we found that there was no significant difference in terms of RDW and MPV in patients with mild and severe pancreatitis according to the Atlanta criteria. Therefore, we can say that MPV and RDW levels are not sufficient and strong parameters to predict the severity and prognosis of pancreatitis. Key Words: Acute Pancreatitis, Red Cell Distribution Width (RDW), Mean Platelet Volume (MPV)

Akut Pankreatitte RDW ve MPV Hastalığın Şiddeti ve Mortalitesinin Bir Prediktörü Olabilir mi?

Abstract

Amaç: Akut pankreatit (AP) tanısıyla hastaneye yatırılan hastalarda yatıştan itibaren hastalığın şiddetini belirlemek tedavinin planlaması için büyük önem arz etmektedir. RDW (Eritrosit Dağılım Hacmi) ve MPV’nin (Ortalama Trombosit Hacmi) pankreatitin şiddetini öngörebilme özelliğinin olup olmadığını araştırmak amacıyla bu çalışmayı yaptık. Materyal ve metod: 2019-2022 yılları arasında AP nedeniyle hastaneye yatırılan 262 hastanın verileri retrospektif olarak incelendi. Hastalar Atlanta kriterleri referans alınarak pankreatitin şiddetine göre gruplara ayrıldı. Daha sonra RDW ve MPV değerlerinin pankreatitin şiddeti ve prognozuyla ilişkisi istatistiksel olarak incelendi. Bulgular: AP’li hastaların %83.9’u (n=220) hafif; %16.1’i (n=42) şiddetli pankreatit idi. Ortalama RDW indeksi hafif AP’li hastalarda 42.5±6.9 fL iken, şiddetli AP hastalarında 42.0±6.6 fL idi (p=0.625). Ortalama MPV seviyesi açısından da her iki grup arasında anlamlı bir farklılık saptanmadı (9.7±1.0 fL vs 9.8±1.3 Fl, p=0.687). Yapılan ROC analizi pankreatitin şiddetini saptayacak anlamlı ve kritik bir MPV ve RDW eşik değerinin olmadığını gösterdi (AUC (MPV): 0.499; AUC (RDW):0.453). Sonuç: AP nedeniyle hastaneye yatırılan ve takipleri sırasında Atlanta kriterlerine göre şiddetli pankreatit gelişen hastaların RDW ve MPV seviyesinin hafif pankreatitli hastalardan farklı olmadığını belirledik. AP’li hastalarda MPV ve RDW seviyesinin pankreatitin şiddetini ve prognozunu öngörmede yeterli ve güçlü bir parametre olmadığını söyleyebiliriz.

Keywords

• Akut Pankreatit
• Eritrosit Dağılım Genişliği (RDW)
• Ortalama Trombosit Hacmi (MPV)

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