The Importance of Uric Acid and Uric Acid/Creatinine in COPD Attack Patients

Abstract

Background: COPD is a chronic inflammatory disease with exacerbations and hypoxemia is par-ticularly severe during exacerbations. Uric acid/creatinine ratio has been shown to be more sen-sitive than uric acid level in showing anaerobic changes due to hypoxia and more correlated with functional parameters of primary diseases that elicit hypoxemia such as COPD. In this study, we aimed to investigate the effectiveness of uric acid and uric acid/creatinine ratio in making hospi-talization decisions in patients admitted to the emergency department with COPD attack. Materials and Methods: The study included 80 patients admitted to the emergency department due to COPD attack. We divided these patients into 3 groups as intensive care unit admission, ward admission and discharged patients. Demographic characteristics, comorbidities, saturation, urea, uric acid, creatinine values and uric acid/creatinine ratio at the time of presentation to the emergency department were analyzed. Results: Of the 80 patients, 35 were admitted to intensive care, 30 were admitted to the ward, and 15 were discharged from the emergency room. While statistically significant difference was found between the saturation values of the groups at emergency admission, urea, uric acid, cre-atinine values and uric acid/creatinine ratio were not statistically significant between the groups (p<0.05). Conclusions: As a result of our study, we concluded that uric acid and uric acid/creatinine ratio were not statistically affected by increasing hypoxia in patients admitted to the emergency de-partment with acute attack of COPD and that these parameters may not be useful in predicting hospitalization.

KOAH Atak Hastalarında Ürik Asit ve Ürik Asit/Kreatinin Önemi

Abstract

Amaç: KOAH alevlenmelerle seyreden kronik inflamatuvar bir hastalıktır ve hipoksemi, özellikle alevlenmeler esnasında şiddetlenir. Ürik asit/kreatinin oranının hipoksiye bağlı anaerobik deği-şiklikleri göstermesinin ürik asit seviyesinden daha sensitif olduğu ve KOAH gibi hipoksemiyi or-taya çıkaran primer hastalıkların fonksiyonel parametreleri ile daha ilişkili olduğu gösterilmiştir. Bu çalışmada KOAH atak ile acil servise başvuran hastalarda yatış kararının verilmesinde ürik asit ve ürik asit/ kreatinin oranının etkinliğini araştırmayı amaçladık. Materyal ve metod: Çalışmaya acil servise KOAH atak nedeni ile başvuran 80 hasta dahil edilmiş-tir. Bu hastaları yoğun bakım yatışı, servis yatışı ve taburcu edilen olmak üzere 3 gruba ayırdık. Hastaların demografik özellikleri, komorbiditeleri, acil servise başvuru anındaki saturasyon, üre, ürik asit, kreatinin değerleri ve ürik asit/kreatinin oranı analiz edildi. Bulgular: 80 hastanın 35’i yoğun bakıma, 30’u servise yatırılmış ve 15’i ise acil servisten taburcu edilmiştir. Grupların acile başvuru saturasyon değerleri arasında istatistiksel olarak anlamlı fark-lılık tespit edilirken (p<0.05) üre, ürik asit, kreatinin değeri ve ürik asit/kreatinin oranı gruplar arasında istatistiksel olarak anlamlı değildi (p>0.05). Sonuç: Yaptığımız çalışmanın sonucunda KOAH akut atak ile acile başvuran hastalarda hipoksi arttıkça ürik asit ve ürik asit/kreatinin oranının istatistiksel olarak etkilenmediğini ve bu paramet-relerin hastaneye yatışı öngörüde faydalı olamayacağı kanısına vardık.

Keywords

• KOAH
• Üre
• Ürik asit/kreatinin

References

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