Karotis Arter Hastalığında Lezyon Ciddiyeti ve Klinik Özellikler Arasındaki İlişki

Abstract

Amaç: Karotis arter hastalığı, akut iskemik inmenin en önde gelen nedenlerindendir. Karotis arter hastalığı, koroner arter hastalığı ile yakından ilişkili olup, aterosklerozis patofizyolojisinde yer alan; yaş, erkek cinsiyet, diabetes mellitus, hipertansiyon, hiperlipidemi ve sigara içiciliği başlıca risk faktörleridir. Çalışmamızda karotis anjiyografi ile karotis arter hastalığı ciddiyeti değerlendirilen hasta grubunda saptanan, lezyon ciddi-yeti ve hastaların sahip olduğu klinik ve laboratuvar özelliklerinin değerlendirilmesi amaçlamıştır. Materyal ve Metod: Bu çalışmaya kliniğimizde karotis anjiyografisi yapılan 208 hasta alındı. Anjiyografik olarak yapılan ölçümlerde karotis arterlerde %50 ve üzerinde darlık saptanan hastalar kritik karotis arter lezyonlu grup, grup 1-n=122 ve %50’nin altında darlık saptanan hastalar ise non-kritik karotis arter lezyonlu grup, grup 2- n=86 olarak ayrıldı. Bulgular: İki grup arasında cinsiyet, vücut kitle indeksi, hipertansiyon, hiperlipidemi, sigara içiciliği ve temel laboratuvar parametreleri açısından farklılık saptanmadı. Grup 1 hastalarında lezyon derecesi %90 (80-95) iken grup 2 de ise %30 (18.75- 40.0) olarak saptandı. Grup 1 hastalarında, serebrovasküler olay öyküsü anlamlı olarak daha yüksek saptandı (%66.4’e karşın %51.2). Grup 2’ye göre yaş, diabetes mellitus ve koro-ner arter hastalığı öyküsü sıklığı grup 1 de anlamlı derecede yüksek saptandı. Yapılan lojistik regresyon analizinde kritik karotis arter hastalığı grubunda en yüksek etkide bulunan durumun ileri yaş olduğu görüldü (Odds oranı: 1.071 [1.032-1.111], p<0.001). Sonuç: Çalışmamızda, karotis arter anjiyografisinde kritik karotis arter lezyonu varlığı %58.7 olarak saptanmış olup, diabetes mellitus ve koroner arter hastalığı öyküsünün ciddi lezyon ile yakından ilişkili olduğu ve en yüksek etkide bulunan durumun ise ileri yaş olduğu görülmüştür.

Keywords

• Karotis Arter Hastalığı
• Yaş
• Diabetes Mellitus
• Koroner Arter Hastalığı

The Relationship between Lesion Severity and Clinical Features in Carotid Artery Disease

Abstract

Background: Carotid artery disease is one of the leading causes of acute ischemic stroke. It is closely associ-ated with coronary artery disease. Atherosclerosis risk factors including age, male gender, diabetes melli-tus, hypertension, hyperlipidemia, and smoking are also the most important factors for carotid artery dis-ease. Our study aimed to evaluate the link between carotid artery lesion severity by carotid angiography and their clinical and laboratory characteristics. Materials and Methods: This study included 208 patients underwent carotid angiography in our clinic. According to angiographic evaluation, study population were divided into two groups as follows: the pa-tients 50% or more were the critical carotid artery lesion group (group 1, n=122), and those with stenosis of less than 50% were non-critical carotid artery lesion group (group, n=86) Results: There was no statistically significant difference between the two groups in terms of gender, body mass index, hypertension, hyperlipidemia, smoking status, and laboratory parameters. The lesion degree was 90% (80-95) in group 1 patients while 30% (18.75- 40.0) in group 2. The history of cerebrovascular event was significantly higher in group 1 patients (66.4% vs. 51.2%). The frequency of age, diabetes melli-tus, and coronary artery disease was significantly higher in group 1 compared to group 2. Logistic regression analysis showed that advanced age had the highest effect on the critical carotid artery disease (Odds ratio 1.071 [1.032-1.111], p<0.001). Conclusions: The prevalence of critical carotid artery lesions was found to be 58.7 in carotid artery angi-ography. The study showed that diabetes mellitus and coronary artery disease history were closely related to critical carotid artery lesions. However, advanced age has the highest independent effect on critical carotid artery lesions.

Keywords

• Carotid Artery Disease
• Age
• Diabetes Mellitus
• Coronary Artery Disease

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