Association Between Dental Caries and Oxidative Stress Parameters in Children

Abstract

Background: The body's oxidant/antioxidant balance and oxidative stress can impact or change dental caries. The main aim of this study was to investigate the association between dental caries and total oxidant status (TOS), total antioxidant status (TAS), and oxidative stress index (OSI).
Materials and Methods: This study was designed in two groups including the control group (DMFS/dfs =0) and the case group with dental caries (DMFS/dfs ≥5). The number of samples in this study includes 94 children, including 42 healthy children and 52 children with dental caries. Unstimulated saliva samples were gathered from all children mid-morning. Participants' saliva samples were obtained by requesting them to spit for 5 min. Then, the specimens were frozen and preserved at a temperature of four °C before being maintained at -80°C until further examination. Results: Children's mean age and mean weight were 6.55±3.52 years and 20.51±9.67 kg, respectively. There was no significant difference between the case and control groups regarding total oxidant status (p<0.01). There was a significant difference between case and control groups in terms of oxidative stress index (p<0.01).
Conclusions: The TOS and OSI were significantly higher in the case group. The TOS and OSI can be employed as markers of oxidative stress caused by dental caries. 

Keywords

• Dental caries
• total oxidant status
• total antioxidant status
• oxidative stress index

Supporting Institution

not applicable

Project Number

23-05- 10.12.2018.

Ethical Statement

Ethical approval for the study was obtained from the Ethics Committee of Harran University Faculty of Medicine (approval no: 18/12/05, date: December 10, 2018).

Thanks

The authors thank the participants for their participation in this study.

Çocuklarda Diş Çürüğü ile Oksidatif Stres Parametreleri Arasındaki İlişki

Abstract

Amaç: Vücudun oksidan/antioksidan dengesi ve oksidatif stres, diş çürüğünü etkileyebilir veya değiştirebilir. Bu çalışmanın temel amacı, diş çürüğü ile toplam oksidan durumu (TOS), toplam antioksidan durumu (TAS) ve oksidatif stres indeksi (OSI) arasındaki ilişkiyi araştırmaktır.
Materyal ve metod: Bu çalışma, kontrol grubu (DMFS/dfs = 0) ve diş çürüğü olan vaka grubu (DMFS/dfs ≥ 5) olmak üzere iki grup halinde tasarlanmıştır. Bu çalışmadaki örnek sayısı, 42 sağlıklı çocuk ve 52 diş çürüğü olan çocuk olmak üzere toplam 94 çocuğu kapsamaktadır. Tüm çocuklardan sabah ortasında uyarılmamış tükürük örnekleri alınmıştır. Katılımcılardan 5 dakika boyunca tükürmeleri istenerek tükürük örnekleri alınmıştır. Daha sonra örnekler dondurulmuş ve 4°C sıcaklıkta muhafaza edilmiş, daha sonra -80 °C'de daha sonraki incelemeye kadar saklanmıştır. Bulgular: Çocukların ortalama yaşı ve ortalama ağırlığı sırasıyla 6,55±3,52 yıl ve 20,51±9,67 kg idi. Vaka ve kontrol grupları arasında toplam oksidan durumu açısından anlamlı bir ilişki bulunmadı (p<0,01). Oksidatif stres indeksi açısından vaka ve kontrol grupları arasında anlamlı bir ilişki vardı (p<0,01).
Sonuç: TOS ve OSI, vaka grubunda anlamlı derecede daha yüksekti. TOS ve OSI, diş çürüğünün neden olduğu oksidatif stresin belirteçleri olarak kullanılabilir.

Keywords

• Diş çürüğü
• toplam oksidan durumu
• toplam antioksidan durumu
• oksidatif stres indeksi

Supporting Institution

uygulanamaz

Project Number

23-05- 10.12.2018.

Ethical Statement

Ethical approval for the study was obtained from the Ethics Committee of Harran University Faculty of Medicine (approval no: 18/12/05, date: December 10, 2018).

Thanks

Yazarlar, bu çalışmaya katılan katılımcılara teşekkür eder.

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