The relationship of intima-media thickness, coronary calcium score and coronary artery disease
Abstract
Background: The aim of this study is to compare the values of carotid artery intima-media thickness (CIMT)
and coronary artery calcium scoring (CACS) in determining extention and severity of coronary artery
disease (CAD) that diagnosed via coronary CT angiography in patients without known diagnosis of CAD
previously.
Methods: 184 patients were included in the study. All patients were undergone CACS examination with 64-
detector MDCTscanner for coronary angiography examination. Following angiography examination, CIMT
was measured for all patients using B-mode ultrasound device with a 7.5 MHz linear probe. According to the
results of coronary CT angiography, patients were classified as normal, mild CAD, moderate CAD,
significant stenotic CAD, severely stenotic CAD. The significant difference of calcium score and CIMT
levels between these groups was examined with statistical analysis.
Results: Calcium score and CIMT showed significant increase in patients with CAD. They were also found
valuable in predicting stenotic CAD, however CACS was found to be more decisive than CIMT for
prediction of stenotic CAD. The best cut-off point for CIMTto predict stenotic CAD was 0.88mm.
Conclusion: CACS and CIMT measurements are valuable in determining extention of CAD, however
CACS has a better correlation with extention and severity of CAD compared with CIMT. When we evaluated
the patients with zero calcium score alone, we found no significant difference in terms of the average CIMT
between the group of existing CAD, and the group of non-existing CAD
Keywords
References
- 1- Lester SJ, Eleid MF, Khandheria BK, Hurst RT. Carotid Intima-Media Thickness and Coronary artery Calcium Score as Indications of Subclinical Atherosclerosis. Mayo Clin Proc 2009; 84(3):229-33 2- Wilson PW, D'Agostino RB, Levy D, Belanger AM, Silbershatz H, Kannel WB. Prediction of coronary heart disease using risk factor categories. Circulation 1998; 97(18):1837–47 3- Conroy RM, Pyörälä K, Fitzgerald AP et al. SCORE Project group Estimation of ten-year risk of fatal cardiovascular disease in Europe: the SCORE Project. Eur Heart J 2003; 24(11):987–1003 4- Rumberger JA, Simons DB, Fitzpatrick LA et al. Coronary artery calcium area by electron-beam computed tomography and coronary aterosclerotic plaque area. A histopathologic correlative study. Circulation 1995; 92:2157-2162 5- O'Leary DH, Polak JF. İntima- Media Thickness: a tool for atherosclerosis imaging and event prediction. Am J Cardiol 2002; 90:18-21 6- Gaemperli O, Valenta I, Schepis T et al. Coronary 64- slice CT angiography predicts outcome in patients with known or suspected coronary artery disease. Eur Radiol 2008; 18:1162–1173 7- Santosa R D, Nasir K. Insights into atherosclerosis from invasive and non-invasive imaging studies: Should we treat subclinical atherosclerosis? Atherosclerosis 2009; 205:349-356 8- Fathi R, Marwick TH. Noninvasive tests of vascular function and structure: why and how to perform them. Am Heart J 2001; 141:694- 703 9- Terry JG, Carr JJ, Tang R et al. Coronary artery calcium outperforms carotid artery intima-media thickness as a noninvasive index of prevalent coronary artery stenosis. Arterioscler Thromb Vasc Biol 2005; 25(8):1723-8. 10- Seese B, Brandt-Pohlmann M, Moshage W, Achenbach S, Schwarz T, Bachmann K. Evaluation of the Association Between Coronary Calcification Detected by Electron Beam Computed Tomography and Atherosclerosis of Extracranial Carotid Arteries In Vivo. Int J Angiol 1998; 7(4):301-6 11- Burke GL, Evans GW, Riley WA et al. Arterial wall thickness is associated with prevalent cardiovascular disease in middle-aged adult The Atherosclerosis Risk in Communities (ARIC) Study. Stroke 1995; 26:386-391 12- Salonen JT, Salonen R. Ultrasonographically assessed carotid morphology and the risk of coronary heart disease. Arterioscler Thromb 1991; 11:1245-1249 13- Chambless LE, Folsom AR, Davis V et al. Risk factors for progression of common carotid atherosclerosis: the Atherosclerosis Risk in Communities Study, 1987-1998. Am J Epidemiol 2002; 155:38-47 14- Salonen JT, Salonen R. Ultrasound B-mode imaging in observational studies of atherosclerotic progression. Circulation 1993; 87( SupplII):56-65 15- Coskun U, Yıldız A, Esen O.B. Relationship between carotid intima-media thickness and coronary angiographic findings:a prospective study. Cardiovascular Ultrasound 2009; 7:59 16- Adams MR, Nakagomi A, Keech Aet al. Carotid intimamedia thickness is only weakly correlated with the extent and severity of coronary artery disease. Circulation 1995; 92: 2127-34 17- Newman AB, Naydeck BL, Ives DG et al. Coronary artery calcium, carotid artery wall thickness and cardiovascular disease outcomes in adults 70 to 99 years old. Am J Cardol 2008; 101(2):186-192 18- Folsom AR, Kronmal RA, Detrano RC et al. Coronary artery calcification compared with carotid intima-media thickness in the prediction of cardiovascular disease incidence: the Multi-Ethnic Study of Atherosclerosis (MESA). Arch Intern Med 2008; 168:1333–1339
Details
Primary Language
English
Subjects
-
Journal Section
Research Article
Publication Date
August 30, 2015
Submission Date
February 19, 2015
Acceptance Date
-
Published in Issue
Year 2015 Volume: 12 Number: 2