İntraserebral hematomlu hastalarda kardiyak etkilenme ve prognoza etkisi

Year 2019, , 266 - 271, 29.08.2019

Gülhan Sarıçam , Oğuzhan Kurşun Şerefnur Öztürk

https://doi.org/10.35440/hutfd.527552

Abstract

Amaç:
Serebrovasküler hastalıkların kardiyak fonksiyonlar üzerine negatif etkileri
olduğu bilinmektedir. Ek olarak, inme kliniğinde uzun dönem izlemde en sık  ve en önemli ölüm nedeni kardiyak
disfonksiyondur. Bu çalışmanın amacı hemorajik inmeli hastalarda kardiyak enzim
ve inflamasyon belirteçlerinin değişimini incelemek ve bu belirteçlerin inme
prognozuna etklerini araştırmaktır.

Materyal ve Metot: Bu 
çalışmaya intraserebral hematom (ISH) 
tanısı ile yatırılan ve hastalığın başlangıcının ilk 24 saati içinde
olan 53 hasta ile 48 kontrol dahil edildi. Her iki grubun da 1., 5. ve 10. gün
kreatinin kinaz (CK), kreatinin kinaz myokardiyal band (CKMB), troponin-I
(Trop-I), C reaktif protein (CRP) ve lökosit değerleri incelendi.

Bulgular: Çalışmaya dâhil edilen 53 hasta ile 48 kontrol
grubu arasında yaş açısından anlamlı farklılık tespit edilmedi (P=0.062). 1.gün
CK, CRP ve lökosit değerleri ile 5. ve 10 gün 
CRP ve lökosit değerleri, ISH grubunda kontrol grubuna göre anlamlı
olarak daha yüksek idi. Bununla beraber, ISH grubunda CK-MB ve troponin
değerlerinin giderek azaldığı, CRP değerlerinin ise giderek arttığı tespit
edildi. 53 kişilik hasta grubunun 13 tanesi takipte exitus oldu. Yaşayan
hastalar ile karşılaştırıldığında, exitus olan hastalarda 1. gün CK, CRP ve
lökosit, 5. gün CK, CK-MB ve CRP ile 10. gün CK, CK-MB ve troponin değerleri
anlamlı olarak daha yüksek idi.

Sonuç:
Çalışmamızda, intraserebral hematom tanılı hastalarda CK-MB ve
troponin değerlerinde 1.günden itibaren bir azalma olduğunu, CRP değerlerinde
ise 1. günden itibaren bir artma olduğunu tespit ettik. Ek olarak, exitus olan
hastalarda kardiyak enzim ve inflamatuvar belirteçlerin daha yüksek olduğunu
tespit ettik. Dolayısıyla hemorajik
inmeli hastalarda myokardiyal hasarın ve inflamasyonun erken dönemde
tanınmasının, morbidite ve mortaliteyi büyük ölçüde azaltabileceğini
düşünüyoruz.

Keywords

Kreatin kinaz, kreatin kinaz miyokardiyal band, C-reaktif protein

Cardiac impairment and its effect on prognosis in patients with intracerebral hematoma

Abstract

Background: Cerebrovascular diseases are known to have
negative effects on cardiac functions. In addition, cardiac dysfunction is the
most common and most important cause of death in the stroke clinic during
long-term follow-up. The aim of this study was to investigate the changes in
cardiac enzyme and inflammation markers in patients with hemorrhagic stroke and
to investigate the effects of these markers on stroke prognosis.

Methods: This study included 53 patients and 48 controls who were hospitalized
for intracerebral hematoma (ICH) and were within the first 24 hours of the
onset of the disease.
Creatinine kinase (CK), creatinine kinase myocardial band (CKMB), troponin-I
(Trop-I), C-reactive protein (CRP) and leukocyte values ​​of both groups were evaluated on the 1st, 5th
and 10th days.

Results: There were no significant differences in age
between 53 patients and 48 control groups (68.50 ± 10.22 versus 71.70 ± 6.02, P
= 0.062). CK, CRP and leukocyte values ​​on day 1 and CRP and leukocyte values ​​on day 5 and 10 were significantly higher in
the ICH group than in the control group. However, CK-MB and Troponin levels
decreased and CRP values ​​increased gradually in ICH group. Thirteen
patients of 53 patients died during follow-up. Compared with the surviving
patients, CK, CRP and leukocytes on day 1, CK, CK-MB and CRP on day 5 and CK,
CK-MB and Troponin on day 10 were significantly higher in patients with exitus.

Conclusions: In
our study, we found a decrease in CK-MB and troponin values ​​from day 1 and an increase in CRP values ​​from day 1 in patients with intracerebral
hematoma. In addition, we found
that cardiac enzymes and inflammatory markers were higher in patients with
exitus.
Therefore, we believe that early recognition of myocardial damage and
inflammation in hemorrhagic stroke patients may significantly reduce morbidity
and mortality.

Keywords

Creatine kinase, creatine kinase myocardial band

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