The Change Of Average Platelet Volume and Platelets Count in Saphenous Vein Embolization Using By Cyanoakrilate

Year 2019, , 272 - 279, 29.08.2019

Cengiz Güven , Mevlüt Doğukan

https://doi.org/10.35440/hutfd.534120

Cited By: 1

Abstract

Background: In the present study, it is aimed to determine the
intervention-related change in the mean platelet volume (MPV) and platelet
count in saphenous vein embolization performed using cyanoacrylate in chronic
venous stasis and varicose treatment, as well as explaining the possible venous
thromboembolism events.

Methods:
60 patients involved in the present study were selected from the patients, who
had varicose and chronic venous stasis and who applied to the Cardiovascular
Surgery Polyclinic of Medical Faculty of Adıyaman University. The files of
patients undergone saphenous vein embolization using CA were performed
digitally and their USG and laboratory results were analyzed. Among 437
patients, 60 patients’ undergone hemogram and biochemical examination before
and after the intervention were involved in the present study. The preoperative
(pre-op) and postoperative (post-op) platelet counts and mean platelet volumes
of the patients were analyzed.

Results: When
compared to the pre-op period, no significant change was observed on 1^st post-ophour
and 1^stpost-op month (p ˃ 0.05), however the MPV value observed on the
3^rd post-op day was significantly higher than the pre-op period (p ˂ 0.05). The MPV value observed on the 3^rd
post-op day was statistically higher than on 1^st post-op hour
(p ˂ 0.05) and the MPV value observed on the 1^st
post-op month was statistically significantly lower than on 3^rd post-op
day (p ˂ 0.05).

Conclusion: MPV did not significantly increase from the normal values on the 1^st
postoperative day, whereas it significantly increased on the 3^rd
postoperative day. Assuming that MPV is related with the increasing
thrombogenicity, it can be stated that the saphenous vein embolization by using
CA that is one of the minimally invasive methods used in varicose treatment may
cause thromboembolic events in the early pre-op period (in the first week). 

Keywords

Mean platelet volume, Varicose, Cyanoacrylate, Thromboembolism

Siyanoakrilat ile Safen Ven Embolizasyonunda Ortalama Trombosit Hacmi ve Trombosit Sayısının Değişimi

Abstract

Amaç: Bu çalışmada amacımız kronik venöz yetmezlik ve varis tedavisinde
siyanoakrilat (CA) ile yapılan safen ven embolizasyonunda işleme bağlı ortalama
trombosit hacminin (MPV) ve trombosit sayısının değişimini saptamak ve
oluşabilecek venöz tromboembolizm olaylarına açıklık getirmektir.

Materyal ve
Metot: Bu çalışmaya dâhil
edilen 60 hasta Adıyaman Üniversitesi Tıp Fakültesi Kalp ve Damar Cerrahisine
Polikliniğine başvuran varis ve kronik venöz yetersizliği olan hastalardan
seçildi. CA ile safen ven embolizasyonu yapılan hastaların dosya taraması
dijital ortamda yapılarak USG ve laboratuvar tetkikleri incelendi. İşlem
yapılan toplam 437 hastadan işlem öncesi ve sonrası hemogram ve biyokimya
tetkikleri alınan60hasta çalışmaya dahil edildi. Hastaların işlem öncesi ve
sonrası trombosit sayısı ve ortalama trombosit hacmi değerlendirildi.

Bulgular: Postoperatif(post-op) 1. Saat ve 1.ay MPV değeri preoperatif (pre-op)
döneme göre anlamlı (p ˃ 0.05) değişim göstermezken post-op 3.gün MPV
değeri pre-op döneme göre anlamlı (p ˂ 0.05)
artış gösterdiği tespit edildi. Post-op 3.gün MPV değeri post op 1.saate
göre anlamlı (p ˂ 0.05) artış ve post-op 1.ay MPV
değeri post-op 3.güne göre anlamlı (p ˂ 0.05)
düşüş göstermiştir.

Sonuç: MPV işlemden 1 gün sonra normal değerlerden anlamlı artış göstermez
iken post op 3. günde anlamlı artış gösterdi. MPV’ün artan trombojenite ile
ilişkili olduğunu varsayarsak varis tedavisinde kullanılan minimal invaziv
yöntemlerden olan CA ile safen ven embolizasyonu post-op erken (İlk bir hafta
içinde) dönemde tromboembolik olaylara sebep olabilmektedir.

     

Keywords

Mean platelet volüm, Varis, Siyanoakrilat, Tromboembolizm

References

• 1- Evans CJ, Fowkes FG, Ruckley CV, Lee AJ. Prevalence of varicose veins and chronic venous insufficiency in men and women in the general population: Edinburgh Vein Study. J Epidemiol Community Health 1999; 53:149–153.
• 2- Yılmaz S. Venöz yetmezlik ve varis tedavisinde güncel yaklaşımlar. Klinik Gelişim 2010; 23:57–62.
• 3- 3-G. Dav`ı and C. Patrono, “Platelet activation and atherothrombosis,”New England Journal of Medicine, vol. 357,no. 24, pp. 2482–2494, 2007
• 4- V. M. Haver and A. R. Gear, “Functional fractionation of platelets,” Journal of Laboratory and Clinical Medicine, vol. 97,no. 2, pp. 187–204, 1981
• 5- J. F. Martin, T. Shaw, J. Heggie, and D. G. Penington, “Measurement of the density of human platelets and its relationship to volume,” British Journal of Haematology, vol. 54, no. 3, pp. 337–352, 1983.
• 6- Koza, P. Grzela˛zka, A. Trofimiuk et al., “Clinical risk factors for loss of stent primary patency in patients with chronic legs ischemia,” Advances in Clinical and Experimental Medicine, vol. 26, no. 2, pp. 311–318, 2017.
• 7- S. Karpatkin, “Heterogeneity of human platelets. VI. Correlation of platelet function with platelet volume,” Blood, vol. 51, no. 2, pp. 307–316, 1978.
• 8- S. G. Chu, R. C. Becker, P. B. Berger et al., “Mean platelet volume as a predictor of cardiovascular risk: a systematic review and meta-analysis,” Journal of 3rombosis and Haemostasis, vol. 8, no. 1, pp. 148–156, 2010.
• 9- A. K. Rao, R. E. Goldberg, and P. N. Walsh, “Platelet coagulant activities in diabetes mellitus. Evidence for relationship between platelet coagulant hyperactivity and platelet volume,” Journal of Laboratory and Clinical Medicine, vol. 103, no. 1, pp. 82–92, 1984.
• 10- Chan YC, Ting AC, Yiu WK, et al. Cyanoacrylate superglue to treat varicose veins: Truly office based and inimally invasive? Eur J Vasc Endovasc Surg 2013; 45:176–177.
• 11- Almeida JI, Kaufman J, Go¨ ckeritz O, et al. Radiofrequency endovenous ClosureFAST versus laser ablation for the treatment of great saphenous reflux: A multicenter, single-blinded, randomized study (RECOVERY study). J Vasc Interv Radiol 2009; 20: 752–759.
• 12- Bozkurt AK1, Yılmaz MF2. A prospective comparison of a new cyanoacrylate glue and laser ablation for the treatment of venous insufficiency.Phlebology. 2016 Mar;31(1 Suppl):106-13. doi: 10.1177/0268355516632652.
• 13- Labenz J and Bo¨ rsch G. Bleeding gastric and duodenal varicose veins: Endoscopic embolisation using tissue adhesives. Dtsch Med Wochenschr 1992; 117: 1274–1277.
• 14- Kobilica N, Flis V and Sojar V. Major complication after histoacryl injection for endoscopic treatment of bleeding peptic ulcer. Endoscopy 2012; 44: E204–205.
• 15- Brothers MF, Kaufmann JC, Fox AJ,et al.N-butyl-2cyanoacrilate substitute for IBCA in interventional neuroradiology:histopathologyc and polymerization time studies.Am J Neuroradiol 1989;10:777-786.
• 16- Machin SJ, Briggs C. Mean platelet volume: a quick, easy determinant of thrombotic risk. J Thromb Haemost 2010;8(1):146–7.
• 17- Bowles KM, Cooke LJ, Richards EM, et al. Platelet size has diagnostic predictive value in patients with thrombocytopenia. Clin Lab Haematol 2005;27(6):370–3.
• 18- Vizioli L, Muscari S, Muscari A. The relationship of mean platelet volume with the risk and prognosis of cardiovascular diseases. Int J Clin Pract 2009;63:1509–1515.
• 19- Noris P, Melazzini F, Balduini CL. New roles for mean platelet volume measurement in the clinical practice? Platelets 2016;27:607–612.
• 20- Zaccardi F, Rocca B, Pitocco D, Tanese L, Rizzi A, Ghirlanda G. Platelet mean volume, distribution width, and count in type 2 diabetes, impaired fasting glucose, and metabolic syndrome: a meta-analysis. Diabetes Metab Res Rev 2015;31:402–410.
• 21- Ren ZJ, Ren PW, Yang B, Liao J, Liu SZ, Lu DL, Wei X, Liu LR, Dong Q. Mean platelet volume, platelet distribution width and platelet count in erectile dysfunction: A systematic review and meta-analysis. Andrologia 2017.
• 22- Kovács S, Csiki Z, Zsóri KS, Bereczky Z, Shemirani AHCharacte-ristics of platelet count and size and diagnostic accuracy of mean platelet volume in patients with venous thromboembolism. A systematic review and meta-analysis. Platelets. 2017 Dec 18:1-9. doi: 10.1080/09537104.2017.1414175.
• 23- Masutani R, Ikemoto T, Maki A, Tanada H, Iwatani Y, Watanabe M, Takubo T, Okada Y. Mean platelet component and mean platelet volume as useful screening markers for myelodysplastic syndrome Health Sci Rep. 2018 May 2;1(5):e50. doi: 10.1002/hsr2.50. eCollection 2018 May.
• 24- Chang J, Lin G, Ye M, Tong D, Zhao J, Zhu D, Yu Q, Zhang W, Li W. Decreased mean platelet volume predicts poor prognosis in metastatic colorectal cancer patients treated with first-line chemotherapy: results from mCRC biomarker study BMC Cancer. 2019 Jan 7;19(1): 15. doi: 10.1186/s12885-018-5252-2.
• 25- Moghadam RH, Shahmohammadi A, Asgari N, Azizi K, Mansour SM, Roozbahani M. Comparison of mean platelet volume levels in coronary artery ectasia and healthy people: systematic review and meta-analysis.Blood Res. 2018 Dec;53(4):269-275. doi: 10.5045/ br.2018.53.4.269. Epub 2018 Dec 17.
• 26- Crawford VL,McNerlan SE, Stout RW.Seasonal changes in platelets, fibrinogen and factor VII in elderlypeople, Age Ageing. 200332(6):661-5.
• 27- Beyan C, Beyan E.Were the measurementsstandardized sufficiently in publıshed studies about mean platelet volüme? Blood Coagul Fibrinolysis.2017;28(3):234-6.
• 28- Kecskemetine G, Csiki Z, Mile M, Zsori KS, Shemirani ZAH. The clinical significance of pneumatic tube transport system on platelet indices: EDTA or citrate anticoagulant? Int J Lab Hematol 2017;39: e102–e105.