Atopik dermatit otoimmün bir hastalık mıdır?

Abstract

Amaç: Atopik dermatitli hastaların serumlarında, kendi proteinlerine karşı IgE tabiatında otoantikorlar saptanmıştır. IgE otoantikorların, atopik dermatit'in patogenezindeki rolleri tam olarak bilinmemektedir. Çalışmamızda, atopik dermatitli hastalar ile sağlıklı bireylere otolog serum deri testi uygulandı ve sonuçlar değerlendirildi. Materyal ve Metod: Atopik dermatitli hastalar ve kontrol grubundaki sağlıklı bireylerin sağ önkol fleksör yüzlerine otolog serum ve serum fizyolojik uygulandı. Bulgular: Atopik dermatitli hastaların %70'inde ve kontrol grubunun %16,7'sinde otolog serum deri testini pozitif olarak saptadık. Atopi anamnezi olan atopik dermatitli hastaların %67,7'sinde otolog serum deri testini pozitif olarak tespit etik. Atopi anamnezi olmayan atopik dermatitli hastalarda bu oran %65,5 düzeyindeydi. SCORAD indeksine göre orta şiddetteki atopik dermatitli hastaların %72'sinde otolog serum deri testini pozitif olarak saptanırken hafif şiddetteki atopik dermatitli hastaların %60'ında otolog serum deri testini pozitif olarak saptadık. Serum total IgE düzeyleri yüksek olan atopik dermatitli hastaların %72,7'sinde otolog serum deri testi pozitif olarak gözlenirken, serum total IgE düzeyleri düşük olan atopik dermatitli hastaların %66,7'sinde otolog serum deri testini pozitif olarak gözlemlendi.Sonuç: Çalışmamızda otolog serum deri testini atopik dermatitli hastaların %70'ninde otolog serum deri testini pozitif olarak saptadık. Atopi anamnezi bulunan atopik dermatitli hastalar, SOCRAD indeksine göre orta şiddetteki hastalar ile serum total IgE düzeyleri yüksek olan atopik dermatitli hastalarda otolog serum deri testinin pozitifliğini yüksek olarak tespit ettik

Keywords

• Otolog serum testi, atopik dermatit, IgE otoantikorları

Is Atopic Dermatitis an Autoimmune Disease?

Abstract

Background: IgE-type autoantibodies against self proteins have been detected in serum of the patients with atopic dermatitis AD . The role of this IgE autoantibodies involved in the pathogenesis of AD remain unclear. The autologus serum skin testing is applied to both AD patients and healthy control and the results are evaluated in our study. Methods: Autologous serum and normal saline are applied to the volar surface of right forearm of all the study groups. Results: The autologous serum skin testing is evaluated positive in 70% of the AD patients and 16.7% of the control group. The test was 67.7% positive in AD patients with a history of atopy whereas 65.5% postive in patients with a negative atopy history. The moderately severe AD patients according to SCORAD scoring system showed 72% positivity on the other hand the test was positive in 60% of the mildly severe AD patients. Test was positive in 72.7% of patients with high serum IgE and 66.7% in patients with low serum IgE. Conclusion: We detected 70% positive autologus serum skin testing in AD patients and test positivity was found higher in patients with atopy history, moderately severe disease calculated by SCORAD index and high serum IgE levels.

Keywords

• Autologous serum skin testing,atopic dermatitis,IgE autoantibodies

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20. High total IgE level (n=33) %72.7 Low total IgE level (n=27) %66.7