Renal disfonksiyonun koroner kan akımı üzerine etkisi

Abstract

Giriş: Yavaş koroner akım YKA uzun zamandır bilinmektedir ve endotel disfonksiyonu ve epikardiyal koroner arterler ve mikrovasküler yatağın aterosklerozu ile ilişkisi bildirilmiştir. Renal disfonksiyonun, ateroskleroz ve endotel disfonksiyonu üzerine etkili olduğu bildirilmiştir. Bu çalışma ile YKA ve kontrol gruplarında TIMI kare sayısı TKS ile ölçülen koroner kan akımı ile renal fonksiyonların ve diğer laboratuar parametrelerinin ilişkisini araştırmayı amaçladık. Gereç ve yöntem: Design and Methods: Çalışmaya koroner kan akım hızları TKS ile değerlendirilmiş olan 92 YKA ve 562 kontrol olgusu dahil edildi. Tahmini glomerüler filtrasyon hızı tGFH Cockcroft-Gault eşitliği ile hesaplandı. TKS ve tGFH ve diğer klinik ve laboratuar parametreler arasındaki ilişki incelendi. Bulgular: Kontrol ve YKA gruplarının kıyaslanmasında iki grup arasında cinsiyet, sistolik kan basıncı, kalp hızı, serum ürik asit ve kreatinin düzeyleri, hematokrit ve tGFH yönünden istatistiksel anlamlı farklılıklar mevcut idi. Ortalama TKS yaş r=0.113, p=0.004 , cinsiyet r=0.152, p

Keywords

• Ateroskleroz,endotel disfonksiyonu,glomerüler filtrasyon hızı,koroner arter hastalığı,koroner mikrovasküler yatak,yavaş koroner akım

Impact of renal dysfunction on coronary blood flow

Abstract

Objectives: Slow coronary flow SCF has long been identified and endothelial dysfunction and atherosclerosis of epicardial coronary arteries and microvasculature were reported to be associated with SCF. Impact of renal functions on atherosclerosis and endothelial dysfunction has been reported. Consequently, we aimed to investigate the association between coronary blood flow by means of TIMI frame count TFC and renal functions and other laboratory parameters in patients with SCF compared to control cases. Design and Methods: Ninety-two patients with SCF and 562 control cases with normal coronary flow were studied after quantifying coronary blood flow according to TFC. Estimated glomerular filtration rate eGFR was evaluated with Cockcroft-Gault equation. The association between TFC and eGFR and other clinical and laboratory parameters were evaluated. Results: There were statistically significant differences between SCF and control groups in respect to gender, systolic blood pressure, heart rate, serum uric acid and creatinine levels, hematocrit and eGFR. Mean TFC was correlated with age r=0.113, p=0.004 , gender r=0.152, p

Keywords

• Atherosclerosis,coronary artery disease,coronary microvasculature,endothelial dysfunction,glomerular filtration rate,slow coronary flow

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