Ozon vs. Melatonin: Alkolik Karaciğer Hastalığında Terapötik Etkileri

Abstract

Amaç: Alkolik karaciğer hastalığı (ALD) dünya çapında bir sağlık sorunudur. Ozon ve melatonin tıbbi tedavilerdeki antioksidan özellikleri için yaygın olarak kullanılan ajanlardır. Biz bu çalışmada ALD’de ozon ve melatonin kullanımını değerlendirmeyi amaçladık.
Materyal ve Metod: Kırk sekiz sıçan kullanılmış ve etanol, melatonin ve ozon uygulanmıştır. Histopatolojik değerlendirme yapılmıştır ve kanda alanin aminotransferaz (ALT), aspartat aminotransferaz (AST), gama glutamil transferaz (GGT), total antioksidan kapasite (TAK), total oksidan kapasite (TOK) ve malondialdehit (MDA); karaciğer dokusunda TAK, TOK ve MDA parametreleri ölçülmüştür.
Bulgular: Çalışılan gruplar arasında ALT, AST aktiviteleri ve TAK, TOK ve MDA düzeyleri açısından istatistiksel olarak anlamlı fark vardı. Alkol kaynaklı toksisite grubunda vasküler konjesyon, hepatosit hasarı, periportal inflamasyon ve mikrovesiküler steatoz tespit edildi.
Sonuç: Histopatolojik bulgular ışığında melatonin ve ozon uygulamalarının alkole bağlı hepatotoksisite için faydalı olduğunu iddia edebiliriz. Bununla birlikte, ozon uygulaması melatoninden daha üstündür.

Anahtar kelimeler: Alkole Bağlı Bozukluklar, Alkolik Karaciğer Hastalıkları, Melatonin, Ozon, Oksidatif Stres

Keywords

• Alkole Bağlı Bozukluklar,Alkolik Karaciğer Hastalıkları,Melatonin,Ozon,Oksidatif stres

Ozone vs Melatonin: The Therapeutic Effects In Alcoholic Liver Disease

Abstract

Background: Alcoholic liver disease (ALD) is a worldwide health problem.Ozone and melatonin are agents that are widely used for their antioxidant properties in medical therapies.In this study, we aimed to evaluate the use of ozone and melatoninin ALD.
Materials and Methods: Forty-eight rats were used and ethanol, melatonin, and ozone were administrated. Histopathological evaluation was performed and activities of alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma glutamyl transferase (GGT) total antioxidant status (TAS), total oxidant status (TOS), and malondialdehyde (MDA)were determined in the blood samples, while TAS, TOS, and MDA parameters were measured in the liver tissue samples.
Results: There were statistically significant differences between the studied groups concerning ALT, AST activities and TAS, TOS, and MDA levels. Vascular congestion, hepatocyte damage, periportal inflammation, and microvesicular steatosis were detected inthe alcohol-induced toxicity group.
Conclusions: In the light of histopathological findings, we can claim that melatonin and ozone administrations are beneficial for alcohol-induced hepatotoxicity. However, ozone application is superior to melatonin. 

Keywords

• Alcohol-Induced Disorders,Alcoholic Liver Diseases,Melatonin,Ozone,Oxidative stress

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