Relationship Between Blood and Pericardial Signal Peptide-CUB (complement C1r / C1s, Vegf and Bmp 1) -EGF (epidermal growth factor)-like Protein-1 (SCUBE-1) Levels and Ventricular Functions in Coronary Artery Bypass Patients

Year 2021, , 384 - 389, 29.12.2021

Nazım Kankılıç , Oğuz Karahan , Sinan Demirtaş , Celal Yavuz , Ahmet Çalışkan , Orkut Güçlü , İbrahim Kaplan

https://doi.org/10.35440/hutfd.986605

Abstract

Background: Signal peptide-CUB (complement C1r/C1s, Uegf, and Bmp1)-EGF (epidermal growth factor)- like domain- containing protein 1(SCUBE-1) is a surface cell protein studied as a biomarker in thrombosis and ischemia conditions and secreted at currently studied early embryogenesis. The aim of this study is to investigate the relationship between left ventricular functions and pericardial / serum SCUBE-1 values of patients who underwent coronary artery bypass surgery.
Material and Methods: Forty patients who underwent cardiopulmonary bypass graft surgery were included in the study. Detailed echocardiographic findings of the patients were made before the operation. Left ventricular dysfunction markers were determined according to left ventricular fracshortening. SCUBE-1 levels were studied with ELISA kits in blood plasma and pericardial fluid samples. SCUBE-1 levels were statistically compared between the determined groups.
Results: Statistical differences were observed in LVDs, IVSd, Neutrophil, RBC, CK-MB, Troponin-I and WBC values in low and high FS groups (p <0.05). SCUBE-1 plasma levels did not differ statistically between the FS groups (p> 0.05). The same situation was similar for pericardial fluid levels (p> 0.05). Correlation was seen between SCUBE-1 plasma levels and SCUBE-1 pericardial levels (p <0.05). There was no significant correlation between echocardiographic findings and SCUBE-1 levels (p> 0.05).
Conclusion: These results showed us that SCUBE-1 plasma and the pericardial fluid levels had no effect on the left ventricular dysfunction. SCUBE-1 is not one of the currently identified markers of cardiac dysfunction. Future studies will further increase our knowledge on this subject.

Keywords

SCUBE-1, Coronary artery bypass, Left ventricular functions

Koroner Arter Bypass hastalarında Kan ve Perikardiyal Signal Peptide-CUB (complement C1r / C1s, Vegf and Bmp 1) -EGF (epidermal growth factor)-like Protein-1 (SCUBE-1) Düzeyleri ve Ventrikül Fonksiyonları Arasındaki İlişki

Abstract

Amaç: Signal peptide-CUB (complement C1r/C1s, Uegf, and Bmp1)-EGF (epidermal growth factor)- like domain- containing protein 1 (SCUBE-1), tromboz ve iskemi koşullarında biyobelirteç olarak incelenen bir yüzey hücresi proteinidir ve erken embriyogenezde salgılanmaktadır. Bu çalışmanın amacı, koroner arter baypas ameliyatı geçiren hastaların sol ventrikül fonksiyonları ile perikardiyal / serum SCUBE-1 değerleri arasındaki ilişkiyi araştırmaktır.
Yöntemler: Çalışmaya kardiyopulmoner baypas greft cerrahisi uygulanan 40 hasta dahil edildi. Hastaların detaylı ekokardiyografik bulguları operasyon öncesi yapıldı. Sol ventrikül disfonksiyon belirteçleri, sol ventrikül fraksiyonunun kısalmasına (left ventricular fracshortening) (FS) göre belirlendi. SCUBE-1 seviyeleri, kan plazması ve perikardiyal sıvı örneklerinde ELISA kitleri ile çalışıldı. SCUBE-1 seviyeleri belirlenen gruplar arasında istatistiksel olarak karşılaştırıldı.
Bulgular: Düşük ve yüksek FS gruplarında LVDs, IVSd, Nötrofil, RBC, CK-MB, Troponin-I ve WBC değerlerinde istatistiksel farklılık gözlendi (p <0,05). SCUBE-1 plazma seviyeleri FS grupları arasında istatistiksel olarak farklılık göstermedi (p> 0.05). Aynı durum perikardiyal sıvı düzeyleri için de benzerdi (p> 0.05). SCUBE-1 plazma seviyeleri ve SCUBE-1 perikardiyal seviyeleri arasında korelasyon görüldü (p <0,05). Ekokardiyografi bulguları ile SCUBE-1 düzeyleri arasında anlamlı korelasyon gözlenmedi (p> 0.05).
Sonuç: Bu sonuçlar bize SCUBE-1 plazma ve perikardiyal sıvı seviyelerinin sol ventrikül disfonksiyonu üzerine etkisi olmadığını gösterdi. SCUBE-1, kardiyak disfonksiyonun şu anda tanımlanmış belirteçlerinden biri değildir. Gelecek çalışmalar bu konudaki bilgimizi daha da artıracaktır.

Keywords

SCUBE-1, Koroner arter baypas, Sol ventrikül fonksiyonları

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