Fetal cinsiyet sağlıklı gebelerde serum plasental alkalen fosfataz seviyelerini etkileyebilir mi?
Year 2017,
Volume: 14 Issue: 2, 111 - 116, 31.08.2017
Hacer Uyanıkoğlu
,
Sibel Sak
,
Adnan İncebıyık
Abstract
Amaç: Normal term gebeliklerde fetal cinsiyetin maternal
plasental alkalen fosfataz (ALP) seviyesine etkisinin
araştırılması amaçlandı.
Yöntem ve Gereçler: Termde olan 88 sağlıklı gebede
serum plasental ALP ölçümü yapıldı. Bebeklerin cinsiyeti
çalışmaya alınan tüm kadınların doğumları
sırasında belirlendi. Plasental ALP seviyeleri kız ve erkek
doğuran gebe kadınlar arasında karşılaştırıldı.
Bulgular: Kız fetüse sahip gebelerde plasental ALP
düzeyleri daha yüksek olmakla birlikte bu farklılık
istatistiksel olarak anlamlı değildi (p > 0.05).
Sonuç: 38 - 39’uncu gebelik haftalarında fetal cinsiyetin
maternal serum plasental ALP seviyelerini sağlıklı gebe
kadınlarda etkilemediği görüldü.
Anahtar Kelimeler: Amaç: Normal term gebeliklerde fetal cinsiyetin maternal
plasental alkalen fosfataz (ALP) seviyesine etkisinin
araştırılması amaçlandı.
Yöntem ve Gereçler: Termde olan 88 sağlıklı gebede
serum plasental ALP ölçümü yapıldı. Bebeklerin cinsiyeti
çalışmaya alınan tüm kadınların doğumları
sırasında belirlendi. Plasental ALP seviyeleri kız ve erkek
doğuran gebe kadınlar arasında karşılaştırıldı.
Bulgular: Kız fetüse sahip gebelerde plasental ALP
düzeyleri daha yüksek olmakla birlikte bu farklılık
istatistiksel olarak anlamlı değildi (p > 0.05).
Sonuç: 38 - 39’uncu gebelik haftalarında fetal cinsiyetin
maternal serum plasental ALP seviyelerini sağlıklı gebe
kadınlarda etkilemediği görüldü.
Anahtar Kelimeler: Fetal, cinsiyet, plasental alkalen
fosfataz,
References
- 1. Fishman WH. Perspectives on alkaline phosphatase
isoenzymes. Am J Med 1974;56(5):617-50.
- 2. Mazda T, Gyure WL. Assay of alkaline phosphatase
isoenzymes by a convenient precipitation and inhibition
methodology. Chem Pharm Bull 1988;36(5):1814–8.
- 3. Okesina AB, Donaldson D, Lascelles PT, Morris P.
Effect of gestational age on levels of serum alkaline
phosphatase isoenzymes in healthy pregnant women. Int J
Gynecol Obstet 1995;48(1):25–9.
- 4. Obiekwe BC, Chard T. Placental proteins in late
pregnancy, relation to fetal sex. J Obstet Gynaecol
1983;3:163–4.
- 5. Lorzadeh N, Kazemirad S. The effects of fetal gender on
serum human chorionic gonadotropin and testosterone in
normotensive and preeclamptic pregnancies. J Pregnancy
2012;2012:874290. doi: 10.1155/2012/874290.
- 6. Wojcicka Bentyn J, Czajkowski K, Sienko J, Grymowicz
M, Bros M. Extremely elevated activity of serum alkaline
phosphatase in gestational diabetes: a case report. Am J
Obstet Gynecol 2004;190(2):566–7.
- 7. Vongthavaravat V, Numberger MM, Balodimos N,
Blanchette H, Koff RS. Isolated elevation of serum alkaline
phosphatase level in an uncomplicated pregnancy: a case
report. Am J Obstet Gynecol 2000;183(2):505–6.
- 8. Hatzmann W, Becker R, Maeso M, Hoffken H.
Excessive rise in plasma alkaline phosphatase in the last
trimester of pregnancy. Geburtshilfe Fraunheilkd
1994;54(6):378–80.
- 9. Adeniyi FA, Olatunbosun DA. Origins and significance
of the increased plasma alkaline phosphatase during normal
pregnancy and pre-eclampsia. Br J Obstet Gynaecol
1984;91(9):857–62.
- 10. Bashiri A, Katz O, Maor E, Sheiner E, Pack I, Mazor
M. Positive placental staining for alkaline phosphatase
corresponding with extreme elevation of serum alkaline
phosphatase during pregnancy. Arch Gynecol Obstet
2007;275:211-4.
- 11. Paul L, Wolf MD. Clinical significance of increased or
decreased serum alkaline phosphatase isoenzymes. Clin
Lab Med 1986;6(3):525–32.
- 12. Gol M, Sisman AR, Guclu S, Altunyurt S, Onvural B,
Demir N. Fetal gender affects maternal serum total and
placental alkaline phosphatase levels during pregnancy.
Eur J Obstet Gynecol Reprod Biol 2006;128(1-2):253-6.
- 13. Agrawal YP, Ylikangas P, Parviainen MT, Penttila IM.
Flow cytometric method to measure urea-resistant alkaline
phosphatase from blood neutrophils for use in the prenatal
screening of Down’s syndrome. Prenat Diagn
1994;14(12):1141–9.
- 14. Moawad AH, Goldenberg RL, Mercer B, et al. The
Preterm Prediction Study: the value of serum alkaline
phosphatase, alpha-fetoprotein, plasma corticotropinreleasing
hormone, and other serum markers for the
prediction of spontaneous preterm birth. Am J Obstet
Gynecol 2002;186(5):990–6.
- 15. Yaron Y, Lehavi O, Urtreger A, Gull I, Lessing J.
Maternal serum hCG is higher in the presence of a female
fetus as early as week 3 postfertilization. Hum Reprod
2002;17(2):485–9.
- 16. Vergnes HA, Denier CJ, Brisson-Lougarre A, Grozdea
JG. Fetal sex and variations in kinetic properties of
neutrophil alkaline phosphatase during the second trimester
of normal pregnancy. Early Hum Dev 1998;51(1):1–5.
- 17. Steier J, Myking O, Bergsjo P. Correlation between
fetal sex and human chorionic gonadotropin in peripheral
maternal blood and amniotic fluid in second and third
trimester normal pregnancies. Acta Obstet Gynecol Scand
1999;78(5):367–71.
Could fetal gender affect maternal serum placental alkaline phosphatase levels in healthy pregnant women?
Year 2017,
Volume: 14 Issue: 2, 111 - 116, 31.08.2017
Hacer Uyanıkoğlu
,
Sibel Sak
,
Adnan İncebıyık
Abstract
Aim: We aimed to research whether fetal gender affects maternal placental alkaline phosphatase (ALP) levels in uncomplicated pregnancies with late term. Materials and Methods: The serum placental ALP measurement was carried out in 88 healthy pregnant women at 38 - 39 weeks of gestation. Infant sex was determined at the delivery for all women included in this study. Placental ALP levels were compared between pregnant women bearing female and male fetuses. Results: Although placental ALP levels were slightly higher in pregnant women carrying female fetuses than in male bearing pregnant women, this difference was not statistically significant (p > 0.05). Conclusions: Fetal gender was seen not to affect maternal serum placental ALP levels in healthy pregnant women at 38 - 39 weeks of gestation. :
References
- 1. Fishman WH. Perspectives on alkaline phosphatase
isoenzymes. Am J Med 1974;56(5):617-50.
- 2. Mazda T, Gyure WL. Assay of alkaline phosphatase
isoenzymes by a convenient precipitation and inhibition
methodology. Chem Pharm Bull 1988;36(5):1814–8.
- 3. Okesina AB, Donaldson D, Lascelles PT, Morris P.
Effect of gestational age on levels of serum alkaline
phosphatase isoenzymes in healthy pregnant women. Int J
Gynecol Obstet 1995;48(1):25–9.
- 4. Obiekwe BC, Chard T. Placental proteins in late
pregnancy, relation to fetal sex. J Obstet Gynaecol
1983;3:163–4.
- 5. Lorzadeh N, Kazemirad S. The effects of fetal gender on
serum human chorionic gonadotropin and testosterone in
normotensive and preeclamptic pregnancies. J Pregnancy
2012;2012:874290. doi: 10.1155/2012/874290.
- 6. Wojcicka Bentyn J, Czajkowski K, Sienko J, Grymowicz
M, Bros M. Extremely elevated activity of serum alkaline
phosphatase in gestational diabetes: a case report. Am J
Obstet Gynecol 2004;190(2):566–7.
- 7. Vongthavaravat V, Numberger MM, Balodimos N,
Blanchette H, Koff RS. Isolated elevation of serum alkaline
phosphatase level in an uncomplicated pregnancy: a case
report. Am J Obstet Gynecol 2000;183(2):505–6.
- 8. Hatzmann W, Becker R, Maeso M, Hoffken H.
Excessive rise in plasma alkaline phosphatase in the last
trimester of pregnancy. Geburtshilfe Fraunheilkd
1994;54(6):378–80.
- 9. Adeniyi FA, Olatunbosun DA. Origins and significance
of the increased plasma alkaline phosphatase during normal
pregnancy and pre-eclampsia. Br J Obstet Gynaecol
1984;91(9):857–62.
- 10. Bashiri A, Katz O, Maor E, Sheiner E, Pack I, Mazor
M. Positive placental staining for alkaline phosphatase
corresponding with extreme elevation of serum alkaline
phosphatase during pregnancy. Arch Gynecol Obstet
2007;275:211-4.
- 11. Paul L, Wolf MD. Clinical significance of increased or
decreased serum alkaline phosphatase isoenzymes. Clin
Lab Med 1986;6(3):525–32.
- 12. Gol M, Sisman AR, Guclu S, Altunyurt S, Onvural B,
Demir N. Fetal gender affects maternal serum total and
placental alkaline phosphatase levels during pregnancy.
Eur J Obstet Gynecol Reprod Biol 2006;128(1-2):253-6.
- 13. Agrawal YP, Ylikangas P, Parviainen MT, Penttila IM.
Flow cytometric method to measure urea-resistant alkaline
phosphatase from blood neutrophils for use in the prenatal
screening of Down’s syndrome. Prenat Diagn
1994;14(12):1141–9.
- 14. Moawad AH, Goldenberg RL, Mercer B, et al. The
Preterm Prediction Study: the value of serum alkaline
phosphatase, alpha-fetoprotein, plasma corticotropinreleasing
hormone, and other serum markers for the
prediction of spontaneous preterm birth. Am J Obstet
Gynecol 2002;186(5):990–6.
- 15. Yaron Y, Lehavi O, Urtreger A, Gull I, Lessing J.
Maternal serum hCG is higher in the presence of a female
fetus as early as week 3 postfertilization. Hum Reprod
2002;17(2):485–9.
- 16. Vergnes HA, Denier CJ, Brisson-Lougarre A, Grozdea
JG. Fetal sex and variations in kinetic properties of
neutrophil alkaline phosphatase during the second trimester
of normal pregnancy. Early Hum Dev 1998;51(1):1–5.
- 17. Steier J, Myking O, Bergsjo P. Correlation between
fetal sex and human chorionic gonadotropin in peripheral
maternal blood and amniotic fluid in second and third
trimester normal pregnancies. Acta Obstet Gynecol Scand
1999;78(5):367–71.