Tip II Diyabetes Mellituslu Hastalarda Serum Ürik Asit Ve Gama Glutamil Transferaz Düzeyleri İle Koroner Arter Hastalığı Gelişimi Arasındaki İlişki

Year 2016, Volume: 13 Issue: 3, 231 - 236, 30.12.2016

Ekrem Aksu Deniz Avcı , Gürkan Çıkım , Yunus Çelik

Abstract

Amaç: Çalışmamızda koroner arter hastalığının (KAH) eşlik ettiği tip 2 diyabetesmellituslu (DM) hastalarla
tip 2 DM tanısıyla takip edilen hastalar serum ürik asit (SÜA) ve gama glutamiltransferaz (GGT) düzeyleri
diğer metabolik parametreler ile birlikte incelenerek prospektif olarak karşılaştırılmış; diyabetik hastalarda
bu parametreler ile KAH gelişimi arasındaki ilişki ortaya koymak amaçlanmıştır.
Gereç ve Yöntem: Kahramanmaraş Necip Fazıl Şehir Hastanesi\'nde gerçekleştirilen bu çalışmaya,
kardiyoloji polikliniğine başvuran tip II DM'lI 118 hasta, KAH\'nın eşlik ettiği 222 adet tip 2 DM\'li hasta
dahil edildi.
Bulgular: Guruplar arasında SÜA düzeylerinde anlamlı farkın olmadığı (5.37±1.48 vs 5.27±1.51 mg/dl;
p=0.194), GGT düzeyinin ise tip II DM'nin eşlik ettiği KAH olan grupta sadece tip II DM olan gruba göre
istatistiki olarak anlamlı olarak daha yüksek olduğunu tespit ettik(23,0 (16,0-32,50) vs 25 (18,0-39,0) U/L; P
< 0,0001).
Sonuç: Çalışmamızda serum GGTdüzeyinin diyabetli hastalarda kardiyovasküler riskin artışını gösteren bir
prediktör olabileceğini gözlemledik. Ancak SÜAseviyesiyle tip II DM'li hastalarda KAH riski arasında ilişki
saptanamamıştır

Keywords

Ürik Asid, Gama glutamil Transferaz, Tip II Diyabetes Mellitus, Koroner Arter Hastalığı

The Relationship Between Type 2 DM Patients With Serum Uric Acid And Gamma Glutamyl Transferase Levels and Development Coronary Artery Disease

Abstract

Objective: In this study we prospectively compared the patients with coronary artery disease (CAD)
accompanied type 2 diabetes mellitus (DM) and patients followed with type 2 diabetes in view of the serum
uric acid (SUA) and glutamil gamma transferase (GGT) levels furthermore metabolic parameters; it is
targeted to reveal the relationship between these parameters and CAD development risk in diabetic patients.
Materials-Methods: 118 patients with type ll DM and 222 type 2 DM patients with CAD who were applied
to the cardiology output clinic enrolled to the study.
Results: No significant difference was established between groups for SUAlevels (5.37 ± 1,48 vs 5.27±1,51
mg/dl; p=0,194) , while the GGT levels in CAD with type ll DM detected statistically significent higher than type II DM group(23.0 (16,0-32,50) vs 25 (18,0-39,0)U/L; P< 0,001).
Conclusion: We observed serum GGTlevels in DM patients are a predictor of the raising cardiovascular risk.
However, SUAlevels in type II DM are not have a relation with the risk of CAD.

Keywords

Uric Acid, Gamma Glutamyl Transferase, Type Ii Diabetes Mellitus, Coronary Artery Disease

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