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Vitamin B12 Eksiliğinde Hastalarda Ortalama Trombosit Volümün Değerlendirilmesi

Year 2014, Volume: 11 Issue: 3, 253 - 256, 15.12.2014

Abstract

Amaç: Bu çalışmada vitamin B12 eksiliği olan çocuklarda Ortalama Trombosit Volümünün
değerlendirilmesi amaçlandı.
Metaryal ve metod: Vitamin B eksikliği tanısı alan 68 hasta ile 54 sağlıklı kontrol grubu çalışmaya alındı. 12
Hasta ve kontrol grubunun Ortalama Trombosit Volümü ve trombosit sayıları değerlendirildi. Vitamin B12
düzeyi 200 pg/Laltında eksiklik olarak kabul edildi.
Bulgular: Çalışmaya alınan vitamin B eksikliği olan hastaların ortalama trombosit volümü değerleri (7.09 12
± 1.1 fl) ile sağlıklı kontrol grubun ortalama değerleri (6.52 ± 0.7 fl) karşılaştırıldığında istatistiksel olarak
anlamlı derecede yüksek bulunurken (p=0.001), trombosit sayısı açısında istatistiksel olarak anlamlı bir fark
bulunmadı (p>0.05).
Sonuç: Rutin tam kan sayımında ortalama trombosit volümü değerlerine bakarak vitamin B eksikliği 12
yakalanmasının mümkün olabileceğini düşündürmektedir.

References

  • 1) Fenech M. Chromosomal damage rate, aging, and diet. Ann N YAcad Sci, 1998. 854: 23-36. 2) Wilson A, Platt R, Wu Q, Leclerc D, Christensen B, et al. A common variant in methionine synthase reductase combined with low cobalamin (vitamin B12) increases risk for spina bifida. Mol Genet Metab, 1999. 67(4): 317-23. 3) Roschitz B, Plecko B, Huemer M, ark. Nutritional infantile vitamin B12 deficiency: pathobiochemical considerations in seven patients. Arch Dis Child Fetal Neonatal Ed 2005;90:281-2. 4) Brocadello F, Levedianos G, Piccione F, Manara R, Pesenti FF. Irreversible subacute sclerotic combined degeneration of the spinal cord in a vegan subject. Nutrition 2007;23(7-8):622-4. 5) Elzey BD, Tian J, Jensen RJ, Swanson AK, Lees JR, Lentz SR, Stein CS, Nieswandt B, Wang Y, Davidson BL, Ratliff TL. Platelet-mediated modulation of adaptive immunity. A communication link between innate and adaptive immune compartments. Immunity. 2003;19(1):9-19 6) Bath PM, Butterworth RJ. Platelet size: measurement, physiology and vascular disease. Blood Coagul Fibrinolysis. 1996; 7(2):157-61. 7) Sharp DS, Benowitz NL, Bath PM, Martin JF, Beswick AD, Elwood PC. Cigarette smoking sensitizes and desensitizes impedance-measured ADP-induced platelet aggregation in whole blood. Thromb Haemost. 1995; 74(2):730-5. 8) Uysal P, Tuncel T, Olmez D, Babayigit A, Karaman O, Uzuner N. The role of mean platelet volume predicting acute exacerbations of cystic fibrosis in children. Ann Thorac Med. 2011; 6(4): 227-30. 9) Yüksel O, Helvaci K, Başar O, Köklü S, Caner S, Helvaci N, Abayli E, Altiparmak E. An overlooked indicator of disease activity in ulcerative colitis: mean platelet volume. Platelets. 2009; 20(4): 277-81. 10) Yazici S, Yazici M, Erer B, Erer B, Calik Y, Ozhan H, Ataoglu S. The platelet indices in patients with rheumatoid arthritis: mean platelet volume reflects disease activity. Platelets. 2010; 21(2): 122-5. 11) Makay B, Türkyilmaz Z, Unsal E. Mean platelet volume in children with familial Mediterranean fever. Clin Rheumatol. 2009; 28(8): 975-8. 12) Oncel MY, Ozdemir R, Yurttutan S, Canpolat FE, Erdeve O, Oguz SS, Uras N, Dilmen U. Mean platelet volume in neonatal sepsis. J Clin Lab Anal. 2012 ; 26(6): 493-6. 13) Karadag-Oncel E, Ozsurekci Y, Kara A, Karahan S, Cengiz AB, Ceyhan M. The value of mean platelet volume in the determination of community acquired pneumonia in children. Ital J Pediatr. 2013; 8;39:16. 14) Catal F, Bavbek N, Bayrak O, Uz E, Isik B, Karabel M, Degirmencioglu H, Mete E, Akcay A. Platelet parameters in children with upper urinary tract infection: is there a specific response? Ren Fail. 2008;30(4):377-81. 15) Snow CF. Laboratory diagnosis of vitamin B12 and folate deficiency. Arch Intern Med. 1999; 159: 1289- 1298. 16) Drabick JJ, Davis BJ, Byrd JC. Concurrent pernicious anemia and myelodisplastic syndrome. Ann Hemato. 2001;80:243-245. 17) Toh BH, van Driel IR, Gleeson PA. Pernisious anemia. N Eng J Med. 1997;337:1441-1448. 18) Zaki MM. Parasite Platelet Interactions. PUJ; 2011, 4(2): 127-136. 19) Flad, HD, Brandt E. Platelet-derived chemokines: Pathophysiology and therapeutic aspects. Cell Mol Life Sci; 2010, 67 (14):2363-86. 20) Tschoepe D, Roesen P, Esser J, Schwippert B, Nieuwenhuis HK, Kehrel B, Gries FA. Large platelets circulate in an activated state in diabetes mellitus. Semin Thromb Hemost. 1991;17(4):433-8. 21) Zuberi BF, Akhtar N, Afsar S. Comparison of mean platelet volume in patients with diabetes mellitus, impaired fasting glucose and non-diabetic subjects. Singapore Med J. 2008; 49(2):114-6. 22) Martin JF, Bath PM, Burr ML. Influence of platelet size on outcome after myocardial infarction. Lancet. 1991;338(8780):1409-11. 23) Ghahremanfard F, Asghari N, Ghorbani R, Samaei A, Ghomi H, Tamadon M. The relationship between mean platelet volume and severity of acute ischemic brain stroke. Neurosciences (Riyadh). 2013;18(2):147-51. 24) Kario K, Matsuo T, Nakao K. Cigarette smoking increases the mean platelet volume in elderly patients with risk factors for atherosclerosis. Clin Lab Haematol. 1992;14(4):281-7. 25) Bath PM, Missouris CG, Buckenham T, MacGregor GA. Increased platelet volume and platelet mass in patients with atherosclerotic renal artery stenosis. Clin Sci (Lond). 1994;87(2):253-7. 26) Icli A, Aksoy F, Dogan A, Arslan A, Akcay S, Yücel H, Ersoy I, Gorgulu O. Increased Mean Platelet Volume in Hypertrophic Cardiomyopathy. Angiology. 2013. [Epub ahead of print] PubMed PMID: 23564022. 27) Oztürk ZA, Dag MS, Kuyumcu ME, Cam H, Yesil Y, Yilmaz N, Aydinli M, Kadayifci A, Kepekci Y. Could platelet indices be new biomarkers for inflammatory bowel diseases? Eur Rev Med Pharmacol Sci. 2013;17(3):334-41. 28) Liu R, Gao F, Huo J, Yi Q. Study on the relationship between mean platelet volume and platelet distribution width with coronary artery lesion in children with Kawasaki disease. Platelets. 2012;23(1):11-6. 29) Babior BM, Bunn HF. Megaloblastic anemias, In: Braunwald E, Fauci AS, Kasper DL, Hauser SL, Longo DL, Jameson JL, Editors. Harrison's Principles of Internal Medicine. Section 2. Disorders of hematopoiesis, 15th ed. New York. McGraw-Hill Companies 2003; 674-680.

Assessment Of Mean Platelet Volume In Patients Deficiency Vitamin B12

Year 2014, Volume: 11 Issue: 3, 253 - 256, 15.12.2014

Abstract

Objectıve: In this study, we aimed to evaluate mean Platelet Volume (MPV) at children with vitamin B12
deficiency.
Material and method: 68 patients with the diagnosis of vitamin B12 deficiency and 54 healthy children as a
control group were enrolled to study. MPVand platelet counts were evaluated at patients and control groups.
Vitamin B12 level under of 200 pg / Lwere considered to be insufficiency.
Results: İn the study vitamin B12 deficiency patients of mean platelet volume values compared to the
healthy (7.09 ± 1.1 fl) control group (6.52 ± 0.7 fl) was statistically significantly higher mean values
(p=0.001), and platelet count were not statistically significant (p> 0.05).
Conclusions: This study suggests that for the diagnosis of patients with vitamin B12 deficiency may be
indication by looking the values of mean platelet volume in routine complete blood count. 

References

  • 1) Fenech M. Chromosomal damage rate, aging, and diet. Ann N YAcad Sci, 1998. 854: 23-36. 2) Wilson A, Platt R, Wu Q, Leclerc D, Christensen B, et al. A common variant in methionine synthase reductase combined with low cobalamin (vitamin B12) increases risk for spina bifida. Mol Genet Metab, 1999. 67(4): 317-23. 3) Roschitz B, Plecko B, Huemer M, ark. Nutritional infantile vitamin B12 deficiency: pathobiochemical considerations in seven patients. Arch Dis Child Fetal Neonatal Ed 2005;90:281-2. 4) Brocadello F, Levedianos G, Piccione F, Manara R, Pesenti FF. Irreversible subacute sclerotic combined degeneration of the spinal cord in a vegan subject. Nutrition 2007;23(7-8):622-4. 5) Elzey BD, Tian J, Jensen RJ, Swanson AK, Lees JR, Lentz SR, Stein CS, Nieswandt B, Wang Y, Davidson BL, Ratliff TL. Platelet-mediated modulation of adaptive immunity. A communication link between innate and adaptive immune compartments. Immunity. 2003;19(1):9-19 6) Bath PM, Butterworth RJ. Platelet size: measurement, physiology and vascular disease. Blood Coagul Fibrinolysis. 1996; 7(2):157-61. 7) Sharp DS, Benowitz NL, Bath PM, Martin JF, Beswick AD, Elwood PC. Cigarette smoking sensitizes and desensitizes impedance-measured ADP-induced platelet aggregation in whole blood. Thromb Haemost. 1995; 74(2):730-5. 8) Uysal P, Tuncel T, Olmez D, Babayigit A, Karaman O, Uzuner N. The role of mean platelet volume predicting acute exacerbations of cystic fibrosis in children. Ann Thorac Med. 2011; 6(4): 227-30. 9) Yüksel O, Helvaci K, Başar O, Köklü S, Caner S, Helvaci N, Abayli E, Altiparmak E. An overlooked indicator of disease activity in ulcerative colitis: mean platelet volume. Platelets. 2009; 20(4): 277-81. 10) Yazici S, Yazici M, Erer B, Erer B, Calik Y, Ozhan H, Ataoglu S. The platelet indices in patients with rheumatoid arthritis: mean platelet volume reflects disease activity. Platelets. 2010; 21(2): 122-5. 11) Makay B, Türkyilmaz Z, Unsal E. Mean platelet volume in children with familial Mediterranean fever. Clin Rheumatol. 2009; 28(8): 975-8. 12) Oncel MY, Ozdemir R, Yurttutan S, Canpolat FE, Erdeve O, Oguz SS, Uras N, Dilmen U. Mean platelet volume in neonatal sepsis. J Clin Lab Anal. 2012 ; 26(6): 493-6. 13) Karadag-Oncel E, Ozsurekci Y, Kara A, Karahan S, Cengiz AB, Ceyhan M. The value of mean platelet volume in the determination of community acquired pneumonia in children. Ital J Pediatr. 2013; 8;39:16. 14) Catal F, Bavbek N, Bayrak O, Uz E, Isik B, Karabel M, Degirmencioglu H, Mete E, Akcay A. Platelet parameters in children with upper urinary tract infection: is there a specific response? Ren Fail. 2008;30(4):377-81. 15) Snow CF. Laboratory diagnosis of vitamin B12 and folate deficiency. Arch Intern Med. 1999; 159: 1289- 1298. 16) Drabick JJ, Davis BJ, Byrd JC. Concurrent pernicious anemia and myelodisplastic syndrome. Ann Hemato. 2001;80:243-245. 17) Toh BH, van Driel IR, Gleeson PA. Pernisious anemia. N Eng J Med. 1997;337:1441-1448. 18) Zaki MM. Parasite Platelet Interactions. PUJ; 2011, 4(2): 127-136. 19) Flad, HD, Brandt E. Platelet-derived chemokines: Pathophysiology and therapeutic aspects. Cell Mol Life Sci; 2010, 67 (14):2363-86. 20) Tschoepe D, Roesen P, Esser J, Schwippert B, Nieuwenhuis HK, Kehrel B, Gries FA. Large platelets circulate in an activated state in diabetes mellitus. Semin Thromb Hemost. 1991;17(4):433-8. 21) Zuberi BF, Akhtar N, Afsar S. Comparison of mean platelet volume in patients with diabetes mellitus, impaired fasting glucose and non-diabetic subjects. Singapore Med J. 2008; 49(2):114-6. 22) Martin JF, Bath PM, Burr ML. Influence of platelet size on outcome after myocardial infarction. Lancet. 1991;338(8780):1409-11. 23) Ghahremanfard F, Asghari N, Ghorbani R, Samaei A, Ghomi H, Tamadon M. The relationship between mean platelet volume and severity of acute ischemic brain stroke. Neurosciences (Riyadh). 2013;18(2):147-51. 24) Kario K, Matsuo T, Nakao K. Cigarette smoking increases the mean platelet volume in elderly patients with risk factors for atherosclerosis. Clin Lab Haematol. 1992;14(4):281-7. 25) Bath PM, Missouris CG, Buckenham T, MacGregor GA. Increased platelet volume and platelet mass in patients with atherosclerotic renal artery stenosis. Clin Sci (Lond). 1994;87(2):253-7. 26) Icli A, Aksoy F, Dogan A, Arslan A, Akcay S, Yücel H, Ersoy I, Gorgulu O. Increased Mean Platelet Volume in Hypertrophic Cardiomyopathy. Angiology. 2013. [Epub ahead of print] PubMed PMID: 23564022. 27) Oztürk ZA, Dag MS, Kuyumcu ME, Cam H, Yesil Y, Yilmaz N, Aydinli M, Kadayifci A, Kepekci Y. Could platelet indices be new biomarkers for inflammatory bowel diseases? Eur Rev Med Pharmacol Sci. 2013;17(3):334-41. 28) Liu R, Gao F, Huo J, Yi Q. Study on the relationship between mean platelet volume and platelet distribution width with coronary artery lesion in children with Kawasaki disease. Platelets. 2012;23(1):11-6. 29) Babior BM, Bunn HF. Megaloblastic anemias, In: Braunwald E, Fauci AS, Kasper DL, Hauser SL, Longo DL, Jameson JL, Editors. Harrison's Principles of Internal Medicine. Section 2. Disorders of hematopoiesis, 15th ed. New York. McGraw-Hill Companies 2003; 674-680.
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Details

Primary Language Turkish
Journal Section Research Article
Authors

Mahmut Abuhandan This is me

Hüseyin Gümüş This is me

Abdullah Solmaz This is me

Bülent Güzel This is me

Publication Date December 15, 2014
Submission Date April 14, 2014
Acceptance Date September 10, 2014
Published in Issue Year 2014 Volume: 11 Issue: 3

Cite

Vancouver Abuhandan M, Gümüş H, Solmaz A, Güzel B. Vitamin B12 Eksiliğinde Hastalarda Ortalama Trombosit Volümün Değerlendirilmesi. Harran Üniversitesi Tıp Fakültesi Dergisi. 2014;11(3):253-6.

Harran Üniversitesi Tıp Fakültesi Dergisi  / Journal of Harran University Medical Faculty