Bir Prospektif Çalışma: İrritabl Barsak Sendromu\'nda Sitalopram Kullanımı

Year 2014, Volume: 11 Issue: 2, 123 - 129, 01.08.2014

Timuçin Aydoğan Fatih Karababa Serkan Yalçın Salih Selek Turgay Ulaş İbrahim Arslan Ahmet Uyanıkoğlu Haşim Nar

Abstract

Amaç: İrritabl Barsak Sendromu İBS yaygın görülen bir durumdur. Medikal tedavisinde antidepresanlar ve antispazmotikler kullanılır. Çalışmamızda, selektif serotonin reuptake inhibitörü SSRI grubundan bir antidepresan olan sitalopramın, İBS semptomları ve depresyon- anksiyete skorları üzerine etkisini araştırmayı amaçladık.Materyal ve Metot: Çalışmaya, Roma 3 tanı kriterlerine göre İBS tanısı konan 103 hasta alındı. İBS'li hastalar, 3 gruba bölündü: 1. grupta n=29 Beck Depresyon Skoru BDS ve Beck Anksiyete Skoru BAS minimal- hafif derecede olan hastalara, bir antispazmotik olan otilonyum bromide 120 mg/gün verildi. 2. grupta n=41 BDS ve BAS orta- ciddi olanlara, otilonyum bromid 120 mg/gün ve sitalopram 20 mg/gün verildi. 3. grupta n=33 ise yine BDS ve BAS orta- ciddi olanlara, sadece otilonyum bromid 120 mg/gün verildi. 3 aylık tedavinin sonunda, tedavi cevapları İBS şiddeti skorlama sistemi ve BDS- BAS ile değerlendirildi. Bulgular: Tedavi sonunda 1. ve 2. gruplarda BDS ve BAS'larda anlamlı düzelmeler olurken p0,05 . İBS şiddet skorlarında ise, 1. grupta daha belirgin olmak üzere, her üç grupta da istatistiksel olarak anlamlı azalmalar oldu p0,05 .Sonuç: Bulgularımıza göre, İBS'li hastalardaki depresyon ve anksiyete şiddetli değilse, bu hastaların tedavisinde tek başına antipazmotik verilmesi, uygun bir seçenek olabilir

Keywords

İrritabl Barsak Sendromu, sitalopram, anksiyete, depresyon

The use of citalopram in Irritable Bowel Syndrome: A prospective study

Abstract

Background: Irritable Bowel Syndrome IBS is a commonly seen condition. Medications used in its treatment include anti-depressants and anti-spasmotics. This study aimed to examine the effect of citalopram, a selective serotonin reuptake inhibitor groupped antidepressant on IBS symptoms and depression-anxiety scores.Materaial and Methods: 103 patients diagnosed with IBS according to the Rome 3 diagnostic criteria were included in the study. Patientswith IBS were divided into three groups:those with minimal-mild Beck Depression Score BDS and Beck Anxiety Score BAS were only given otilonium bromide 120 mg/day group 1, n=29 , those with moderate- severe scores were given otilonium bromide120 mg/day and citalopram20 mg/day group 2, n=41 and those with moderate- severe scores were only given otilonium bromide 120 mg/day group 3, n=33 . At the end of 3 months treatment, the responses to treatment were evaluated with the IBS severity scoring system and BDS-BAS.Results: While a significant improvement was detected in the BDS and BAS of first and second groups . p0,05 .Statistically significant improvementwas found in IBS severity score of three groups p0,05 .Conclusion: According to our findings, if depression and anxiety in IBS patients are not so severe, a treatment regime with only anti-spasmotics may be an appropriate choice

Keywords

Irritable Bowel Syndrome, citalopram, anxiety, depression

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