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Hipofizer Makrodenom Tanısı Konulan Primer Hipotiroidizme Bağlı Hipofizer Hiperplazi Türkçe

Year 2014, Volume: 11 Issue: 2, 160 - 163, 01.08.2014

Abstract

Primer hipotiroidizm ile hipofizer hiperplazi, arasındaki ilişki oldukça iyi bilinse de, hipotiroid bir olgunun hipofiz hiperplazisine bağlı klİnik semptomları ile fark edilmesi nadir bir durumdur. Yazımızda baş ağrısı nedeniyle değerlendirilirken hipofizer kitle saptanan ve sonrasında hipotiroid de olduğu fark edildiğinden hipofizer hiperplazi olası tanısı ile izlenen bir olgu sunulmuştur. Olguda saptanan hipofizer kitlenin levotiroksin tedavisi ile radyolojik olarak küçüldüğü gösterilmiştir. Primer hipotiroidizme bağlı hipofizer hiperplazi ko-insidental hipofiz adenomları ile karışabilir. Radyolojik olarak hipofiz adenomu-hiperplazisi ayırımı yapmak oldukça güçtür. Ayırıcı tanıda hastanın klinik öyküsü, hormonal parametreler ve kitlenin levotiroksin replasmanı ile küçüldüğünün radyolojik olarak gösterilmesi önemlidir

References

  • ) Joshi AS. Pituitary hyperplasia secondary to primary hypothyroidism: A Case report and Review of the literature. Pituitary 2005;8:99-103.
  • ) Horvath E, Kovacs K, Scheithauer BW. Surgical pathology of pituitary thyrotroph hyperplasia: An oxymoron? Endocr Pathol 1992;3:(Suppl.1)514–515. immunocytochemical study. Virchows Archiv B, Cell Pathol 1992;62:291–6.
  • ) Horvath E, Kovacs K, Scheithauer BW. Pituitary hyperplasia. Pituitary 1999;1:169-180.
  • ) Koller KJ, Wolff RS, Warden MK, Zoeller RT. Proc Natl Acad Sci U S A. 1987 Oct;84(20):7329-33.
  • ) Sarlis NJ, Brucker-Davis F, Doppman JL, Skarulis MC. J Clin Endocrinol Metab. 1997 Mar;82(3):808-11.
  • ) Chan AW, MacFarlane IA, Foy PM, Miles JB. Pituitary enlargement and hyperprolactinemia due to primary hypothyroidism: errors and delays in diagnosis. Br J Neurosurg 1990;4:107-12.
  • ) Wolanski LJ, Leavitt GD, Elias BJ, Lee HJ, Dasmahapatra A, Byrne W. MRI of pituitary hyperplasia in hypothyroidism. Neuroradiology 1996; 38:50-2.
  • ) Kuroiwa T, Okabe Y, Hasuo K, Yasumori K, Mizushima A, Masuda K. MR imaging of pituitary hypertrophy due to juvenile primary hypothyroidism:a case report. Clin Imaging. 1991;15:202-5.
  • ) Ahmed M, Banna M, Sakati N, Woodhouse N. Pituitary gland enlargement in primary hypothyroidism: a report of 5 cases with follow-up data.Horm Res 1989;32:188-92.
  • ) Beressi N, Cohen R, Beressi J-P, Legrand M, Iba-Zizen M-T. Modigliani E. Pseudotumoral lymphocytic hypophysistis successfully treated by corticosteroid alone: First case report. Neurosurgery 1994;35:505-8.

Pituitary Hyperplasia Due to Primary Hypothyroidism Which Diagnosed as Pituitary Macroadenoma

Year 2014, Volume: 11 Issue: 2, 160 - 163, 01.08.2014

Abstract

Although the association of pituitary hyperplasia and primary hypothyroidism is well known, recognition of hypothyroidism due to pituitary hyperplasia is a rare occurence.We report a case of a probable pituitary hyperplasia who complaint with headache, and found to have pituitary hyperplasia during evaluation of headache and co-incidental hypothyroidism. Pituitary mass image has been shrinked with levothyroxin therapy.Pituitary hyperplasia due to primary hypothyroidism can be confused with coincidental pituitary adenomas. Radiological distinction between hyperplasia and adenomas is difficult. Patient history, hormonal parameters and radiological regression of the mass image with levothyroxin therapy are important clues in differential diagnosis

References

  • ) Joshi AS. Pituitary hyperplasia secondary to primary hypothyroidism: A Case report and Review of the literature. Pituitary 2005;8:99-103.
  • ) Horvath E, Kovacs K, Scheithauer BW. Surgical pathology of pituitary thyrotroph hyperplasia: An oxymoron? Endocr Pathol 1992;3:(Suppl.1)514–515. immunocytochemical study. Virchows Archiv B, Cell Pathol 1992;62:291–6.
  • ) Horvath E, Kovacs K, Scheithauer BW. Pituitary hyperplasia. Pituitary 1999;1:169-180.
  • ) Koller KJ, Wolff RS, Warden MK, Zoeller RT. Proc Natl Acad Sci U S A. 1987 Oct;84(20):7329-33.
  • ) Sarlis NJ, Brucker-Davis F, Doppman JL, Skarulis MC. J Clin Endocrinol Metab. 1997 Mar;82(3):808-11.
  • ) Chan AW, MacFarlane IA, Foy PM, Miles JB. Pituitary enlargement and hyperprolactinemia due to primary hypothyroidism: errors and delays in diagnosis. Br J Neurosurg 1990;4:107-12.
  • ) Wolanski LJ, Leavitt GD, Elias BJ, Lee HJ, Dasmahapatra A, Byrne W. MRI of pituitary hyperplasia in hypothyroidism. Neuroradiology 1996; 38:50-2.
  • ) Kuroiwa T, Okabe Y, Hasuo K, Yasumori K, Mizushima A, Masuda K. MR imaging of pituitary hypertrophy due to juvenile primary hypothyroidism:a case report. Clin Imaging. 1991;15:202-5.
  • ) Ahmed M, Banna M, Sakati N, Woodhouse N. Pituitary gland enlargement in primary hypothyroidism: a report of 5 cases with follow-up data.Horm Res 1989;32:188-92.
  • ) Beressi N, Cohen R, Beressi J-P, Legrand M, Iba-Zizen M-T. Modigliani E. Pseudotumoral lymphocytic hypophysistis successfully treated by corticosteroid alone: First case report. Neurosurgery 1994;35:505-8.
There are 10 citations in total.

Details

Primary Language Turkish
Journal Section Case Report
Authors

Ayşe Nur Torun This is me

Hasan Çeçe This is me

Mehmet Ali Eren This is me

Fuat Torun This is me

Tevfik Sabuncu This is me

Publication Date August 1, 2014
Published in Issue Year 2014 Volume: 11 Issue: 2

Cite

Vancouver Torun AN, Çeçe H, Eren MA, Torun F, Sabuncu T. Hipofizer Makrodenom Tanısı Konulan Primer Hipotiroidizme Bağlı Hipofizer Hiperplazi Türkçe. Harran Üniversitesi Tıp Fakültesi Dergisi. 2014;11(2):160-3.

Harran Üniversitesi Tıp Fakültesi Dergisi  / Journal of Harran University Medical Faculty