Investigation of Association Between Tlr2 And Tlr4 Gene Polymorphisms and Acne in Turkish Subjects

Ebru Onalan Etem; İbrahim Kokcam; Sevinay Oguz; Halit Elyas; Yasemin Askın

Türk Toplumunda Tlr2 ve Tlr4 Gen Polimorfizmleri ile Akne Arasındaki İlişkinin Araştırılması English

Year 2014, Volume: 11 Issue: 1, 1 - 9, 01.04.2014

Ebru Onalan Etem İbrahim Kokcam Sevinay Oguz Halit Elyas Yasemin Askın

Abstract

Amaç: Bu çalışmada büyüme ağrısı olan çocuk ve ergenlerde, rahatsızlığın yaşam kalitesine olan etkisinin değerlendirilmesi amaçlandı.Metaryal ve metod: Büyüme ağrısı tanısı alan 30 hasta ile birlikte yaş ve cinsiyetleri eşleşmiş 30 sağlam çocuk kontrol grubu olarak çalışmaya dahil edildi. Gruplara, Çocuklar için Depresyon Ölçeği ÇDÖ , Çocuklar için Durumluk-Süreklilik Kaygı Ölçeği ÇDSKÖ ve Çocuklar için yaşam kalitesi ölçeklerinin Ebeveyn ve Çocuk formları ÇİYKÖ-E ve C uygulandı. Bulgular: Büyüme ağrısı olan çocuk ve ergenlerin, kontrol gruplarına göre ÇDSKÖ ve ÇDÖ ölçek puanlari yüksek bulunurken, ÇİYKÖ-E ve C formları puanları istatistiksel olarak anlamlı derecede düşük bulundu p

Keywords

Fonksiyonel büyüme ağrısı, çocuk, ergen, yaşam kalitesi

References

)Leyden JJ, McGinley KJ, Mills OH, Kligman AM. Propionibacterium levels in patients with and without acne vulgaris. J Invest Dermatol 1975; 65(4): 382-4.
) Cunliffe WJ, Gould DJ. Prevalence of facial acne vulgaris in late adolescence and in adults. Br Med J ; 1(6171):1109–10.
) Michalak-Stoma A, Tabarkiewicz J, Olender A, Juszkiewicz-Borowiec M, Stoma F, Pietrzak A, Pozarowski P, Bartkowiak-Emeryk M. The effect of Propionibacterium acnes on maturation of dendritic cells derived from acne patients' peripherial blood mononuclear cells. Folia Histochem Cytobiol 2008; (4):535-9.
) Harper JC, Thiboutot DM. Pathogenesis of acne: research advances. Adv Dermatol 2003; 19:1-10.
) Takeda K, Kaisho T and Akira S. Toll-like receptors. Annu Rev Immunol 2003; 21:335-76.
) Dabbagh K and Lewis DB. Toll-like receptors and T- helper-1/T-helper-2 responses. Curr Opin Infect Dis ;16(3):199–204. ) Jugeau S, Tenaud I, Knol AC, Jarrousse V, Quereux G, Khammari A, Dreno B. Induction of toll-like receptors by Propionibacterium acnes. Br J Dermatol 2005; (6): 1105–13.
) Kim J, Ochoa MT, Krutzik SR, Takeuchi O, Uematsu S, Legaspi AJ, Brightbill HD, Holland D, Cunliffe WJ, Akira S, Sieling PA, Godowski PJ, Modlin RL. Activation of Toll-Like Receptor 2 in Acne Triggers Inflammatory Cytokine Responses. J Immunol 2002; (3):1535-41.
) Lorenz E, Mira JP, Cornish KL, Arbour NC, Schwartz DA. A novel polymorphism in the toll-like receptor 2 gene and its potential association with staphylococcal infection. Infect Immun 2000; 68(11):6398–401.
) Kamisango K, Saiki I, Tanio Y, Okumura H, Araki Y, Sekikawa I, Azuma I, Yamamura Y. Structures and biological activities of peptidoglycans of Listeria monocytogenes and Propionibacterium acnes. J Biochem 1982; 92(1): 23-33.
) Ogus AC, Yoldas B, Ozdemir T, Uguz A, Olcen S, Keser I, Coskun M, Cilli A, Yegin O. The Arg753Gln polymorphism of the human Toll-like receptor 2 gene in tuberculosis disease. Eur Respir J 2004; 23(2): 219–23.
) Park Y, Park S, Yoo E, Kim D, Shin H. Association of the polymorphism for Toll-like receptor 2 with type 1 diabetes susceptibility. Ann N Y Acad Sci 2004; 1037: –4.
) Koreck A, Kis K, Szegedi K Paunescu V, Cioaca R, Olariu R, Negru S, Bata-Csorgo Z, Kemeny L, Dobozy A, Szell M. TLR2 and TLR4 polymorphisms are not associated with acne vulgaris. Dermatol 2006; 213(3): 9.
) Kang TJ, Chae GT. Detection of Toll-like receptor 2 (TLR2) mutation in the lepromatous leprosy patients. FEMS Immunol Med Microbiol 2001; 31(1):53-8.
)Arbour NC, Lorenz E, Schutte BC, Zabner J, Kline JN, Jones M, Frees K, Watt JL and Schwartz DA. TLR4 m u t a t i o n s a r e a s s o c i a t e d w i t h e n d o t o x i n hyporesponsiveness in humans. Nat Genet 2000; (2):187–91.
) Agnese DM, Calvano JE, Hahm SJ, Coyle SM, Corbett SA, Calvano SE and Lowry SF. Human toll-like receptor 4 mutations but not CD14 polymorphisms are associated with an increased risk of gram-negative infections. J Infect Dis 2002; 186(10):1522–25.
) Kiechl S, Lorenz E, Reindl M, Wiedermann CJ, Oberhollenzer F, Bonora E, Willeit J and Schwartz DA. Toll-like receptor 4 polymorphisms and atherogenesis. N Engl J Med 2002; 347(3):185–92.
) Ameziane N, Beillat T, Verpillat P, Chollet-Martin S, Aumont MC, Seknadji P, Lamotte M, Lebret D, Ollivier V and de Prost D. Association of the Toll-like receptor 4 gene Asp299Gly polymorphism with acute coronary events. Arterioscler Thromb Vasc Biol 2003; 23(12): –4.
)Calvano JE, Bowers DJ, Coyle SM, Macor M, Reddell MT, Kumar A, Calvano SE, Lowry SF. Response to systemic endotoxemia among humans bearing polymorphisms of the Toll-like receptor 4 (hTLR4). Clin Immunol 2006; 121(2):186-90.
) Schröder NW, Hermann C, Hamann L, Göbel UB, Hartung T, Schumann RR. High frequency of polymorphism Arg753Gln of the toll-like receptor-2 gene detected by a novel allele-specific PCR. J Mol Med 2003; (6): 368–72.
) Pochi PE, Shalita AR, Strauss JS, Webster SB, Cunliffe WJ, Katz HI, Kligman AM, Leyden JJ, Lookingbill DP, Plewing G. Report of the Consensus Conference on Acne Classification. J Am Acad Dermatol ; 24(3): 495–500. ) Tian LM, Xie HF, Yang T, Hu YH, Li J, Wang WZ. Association study of tumor necrosis factor receptor type 2 M196R and toll-like receptor 2 Arg753Gln polymorphisms with acne vulgaris in a Chinese Han ethnic group. Dermatol 2010; 221(3):276-84.
) Lin PT, Krutzik SR, Kim J, Modlin RL. Cutting edge: all-transretinoic acid down-regulates TLR2 expression and function. J Immunol 2005; 174(5): 2467-70.
)Jarrousse V, Castex-Rizzi N, Khammari A, Charveron M, Dréno B. Zinc salts inhibit in vitro Toll-like receptor 2 surface expression by keratinocytes. Eur J Dermatol 2007; (6):492-6.
) Fathy A, Mohamed RW, Ismael NA, El-Akhras MA. Expression of toll-like receptor 2 on peripheral blood monocytes of patients with inflammatory and noninflammatory acne vulgaris. Egypt J Immunol 2009; (1):127-34.
) Kuuliala K, Orpana A, Leirisalo-Repo M, Kautiainen H, Hurme M, Hannonen P, Korpela M, Möttönen T, Paimela L, Puolakka K, Karjalainen A, Repo H. Polymorphism at position +896 of the toll-like receptor 4 gene interferes with rapid response to treatment in rheumatoid arthritis. Ann Rheum Dis 2006; 65(9):1241-3.
) Erridge C, Stewart J and Poxton IR. Monocytes heterozygous for the Asp299Gly and Thr399Ile mutations in the Toll-like receptor 4 gene show no deficit in lipopolysaccharide signalling. J Exp Med 2003; (12):1787–91.
) Von Aulock S, Schroder NW, Gueinzius K, Traub S, Hoffmann S, Graf K, Dimmeler S, Hartung T, Schumann RR and Hermann C. Heterozygous toll-like receptor 4 polymorphism does not influence lipopolysaccharide- induced cytokine release in human whole blood. J Infect Dis ; 188(6): 938–43. ) Van der Graaf C, Kullberg BJ, Joosten L, Verver-Jansen T, Jacobs L, Van der Meer JW and Netea MG. Functional consequences of the Asp299Gly Toll-like receptor-4 polymorphism. Cytokine 2005; 30(5):264–8.
) Van Rijn BB, Roest M, Franx A, Bruinse HW and Voorbij HA. Single step high-throughput determination of Toll-like receptor 4 polymorphisms. J Immunol Methods ; 289(1-2): 81–7. ) Berdeli A, Emingil G, Han Saygan B, Gürkan A, Atilla G, Köse T, Baylas H. TLR2 Arg753Gly, TLR4 Asp299Gly and Thr399Ile gene polymorphisms are not associated with chronic periodontitis in a Turkish population. J Clin Periodontol 2007; 34(7):551–7.
) Schröder NW, Hermann C, Hamann L, Göbel UB, Hartung T, Schumann RR. High frequency of polymorphism Arg753Gln of the Toll-like receptor-2 gene detected by a novel allele-specific PCR. J Mol Med ; 81(6):368-72. )Yoon HJ, Choi JY, Kim CO, Park YS, Kim MS, Kim YK, Shin SY, Kim JM, Song YG. Lack of Toll-like receptor 4 and 2 polymorphisms in Korean patients with bacteremia. J Korean Med Sci 2006; 21(6):979–82.
) Ryu YJ, Kim EJ, Koh WJ, Kim H, Kwon OJ, Chang JH. Toll-like receptor 2 polymorphisms and nontuberculous mycobacterial lung diseases. Clin Vaccine Immunol 2006; 13(7):818–9.
) Paraskevaidis A, Drakoulis N, Roots I, Orfanos CE, Zouboulis CC. Polymorphisms in the human cytochrome P-450 1A1 gene (CYP1A1) as a factor for developing acne. Dermatol 1998; 196(1): 171–5.
) Ostlere LS, Rumsby G, Holownia P, Jacobs HS, Rustin MH, Honour JW. Carrier status for steroid 21- hydroxylase deficiency is only one factor in the variable phenotype of acne. Clin Endocrinol (Oxf) 1998; 48(2): –15.
) Ando I, Kukita A, Soma G, Hino H. A large number of tandem repeats in the polymorphic epithelial mucin gene is associated with severe acne. J Dermatol 1998; 25(3): 150–2.
) He L, Yang Z, Yu H, Cheng B, Tang W, Dong Y, Xiao C. The relationship between CYP17 –34T/C polymorphism and acne in Chinese subjects revealed by sequencing. Dermatol 2006; 212(4): 338–42.
) Pang Y, He CD, Liu Y, Wang KB, Xiao T, Wang YK, Zhu H, Wei B, Zhao N, Jiang Y, Wei HC, Chen HD. Combination of short CAG and GGN repeats in the androgen receptor gene is associated with acne risk in North East China. J Eur Acad Dermatol Venereol 2008; 22(12):1445-51.

Investigation of Association Between Tlr2 And Tlr4 Gene Polymorphisms and Acne in Turkish Subjects

Year 2014, Volume: 11 Issue: 1, 1 - 9, 01.04.2014

Ebru Onalan Etem İbrahim Kokcam Sevinay Oguz Halit Elyas Yasemin Askın

Abstract

Background: In this study, it was aimed to evaluate the effects of growth pain on life quality in children and adolescents.Methods: 30 patients diagnosed with growth pain and 30 healthy children as control group matched of age and gender were included in the study. Child Depression Inventory CDI , State-Trait Anxiety Inventories for Children STAI-C and Pediatric Quality of Life Inventory Parent and Child Versions PedQL-P and C were applied to both patient and control groups.Results: PedQL-P and C scores of children and adolescents with growth pain were statisticaly significance lower than control group p

Keywords

Growth pain, child, adolescent, life quality

References

)Leyden JJ, McGinley KJ, Mills OH, Kligman AM. Propionibacterium levels in patients with and without acne vulgaris. J Invest Dermatol 1975; 65(4): 382-4.
) Cunliffe WJ, Gould DJ. Prevalence of facial acne vulgaris in late adolescence and in adults. Br Med J ; 1(6171):1109–10.
) Michalak-Stoma A, Tabarkiewicz J, Olender A, Juszkiewicz-Borowiec M, Stoma F, Pietrzak A, Pozarowski P, Bartkowiak-Emeryk M. The effect of Propionibacterium acnes on maturation of dendritic cells derived from acne patients' peripherial blood mononuclear cells. Folia Histochem Cytobiol 2008; (4):535-9.
) Harper JC, Thiboutot DM. Pathogenesis of acne: research advances. Adv Dermatol 2003; 19:1-10.
) Takeda K, Kaisho T and Akira S. Toll-like receptors. Annu Rev Immunol 2003; 21:335-76.
) Dabbagh K and Lewis DB. Toll-like receptors and T- helper-1/T-helper-2 responses. Curr Opin Infect Dis ;16(3):199–204. ) Jugeau S, Tenaud I, Knol AC, Jarrousse V, Quereux G, Khammari A, Dreno B. Induction of toll-like receptors by Propionibacterium acnes. Br J Dermatol 2005; (6): 1105–13.
) Kim J, Ochoa MT, Krutzik SR, Takeuchi O, Uematsu S, Legaspi AJ, Brightbill HD, Holland D, Cunliffe WJ, Akira S, Sieling PA, Godowski PJ, Modlin RL. Activation of Toll-Like Receptor 2 in Acne Triggers Inflammatory Cytokine Responses. J Immunol 2002; (3):1535-41.
) Lorenz E, Mira JP, Cornish KL, Arbour NC, Schwartz DA. A novel polymorphism in the toll-like receptor 2 gene and its potential association with staphylococcal infection. Infect Immun 2000; 68(11):6398–401.
) Kamisango K, Saiki I, Tanio Y, Okumura H, Araki Y, Sekikawa I, Azuma I, Yamamura Y. Structures and biological activities of peptidoglycans of Listeria monocytogenes and Propionibacterium acnes. J Biochem 1982; 92(1): 23-33.
) Ogus AC, Yoldas B, Ozdemir T, Uguz A, Olcen S, Keser I, Coskun M, Cilli A, Yegin O. The Arg753Gln polymorphism of the human Toll-like receptor 2 gene in tuberculosis disease. Eur Respir J 2004; 23(2): 219–23.
) Park Y, Park S, Yoo E, Kim D, Shin H. Association of the polymorphism for Toll-like receptor 2 with type 1 diabetes susceptibility. Ann N Y Acad Sci 2004; 1037: –4.
) Koreck A, Kis K, Szegedi K Paunescu V, Cioaca R, Olariu R, Negru S, Bata-Csorgo Z, Kemeny L, Dobozy A, Szell M. TLR2 and TLR4 polymorphisms are not associated with acne vulgaris. Dermatol 2006; 213(3): 9.
) Kang TJ, Chae GT. Detection of Toll-like receptor 2 (TLR2) mutation in the lepromatous leprosy patients. FEMS Immunol Med Microbiol 2001; 31(1):53-8.
)Arbour NC, Lorenz E, Schutte BC, Zabner J, Kline JN, Jones M, Frees K, Watt JL and Schwartz DA. TLR4 m u t a t i o n s a r e a s s o c i a t e d w i t h e n d o t o x i n hyporesponsiveness in humans. Nat Genet 2000; (2):187–91.
) Agnese DM, Calvano JE, Hahm SJ, Coyle SM, Corbett SA, Calvano SE and Lowry SF. Human toll-like receptor 4 mutations but not CD14 polymorphisms are associated with an increased risk of gram-negative infections. J Infect Dis 2002; 186(10):1522–25.
) Kiechl S, Lorenz E, Reindl M, Wiedermann CJ, Oberhollenzer F, Bonora E, Willeit J and Schwartz DA. Toll-like receptor 4 polymorphisms and atherogenesis. N Engl J Med 2002; 347(3):185–92.
) Ameziane N, Beillat T, Verpillat P, Chollet-Martin S, Aumont MC, Seknadji P, Lamotte M, Lebret D, Ollivier V and de Prost D. Association of the Toll-like receptor 4 gene Asp299Gly polymorphism with acute coronary events. Arterioscler Thromb Vasc Biol 2003; 23(12): –4.
)Calvano JE, Bowers DJ, Coyle SM, Macor M, Reddell MT, Kumar A, Calvano SE, Lowry SF. Response to systemic endotoxemia among humans bearing polymorphisms of the Toll-like receptor 4 (hTLR4). Clin Immunol 2006; 121(2):186-90.
) Schröder NW, Hermann C, Hamann L, Göbel UB, Hartung T, Schumann RR. High frequency of polymorphism Arg753Gln of the toll-like receptor-2 gene detected by a novel allele-specific PCR. J Mol Med 2003; (6): 368–72.
) Pochi PE, Shalita AR, Strauss JS, Webster SB, Cunliffe WJ, Katz HI, Kligman AM, Leyden JJ, Lookingbill DP, Plewing G. Report of the Consensus Conference on Acne Classification. J Am Acad Dermatol ; 24(3): 495–500. ) Tian LM, Xie HF, Yang T, Hu YH, Li J, Wang WZ. Association study of tumor necrosis factor receptor type 2 M196R and toll-like receptor 2 Arg753Gln polymorphisms with acne vulgaris in a Chinese Han ethnic group. Dermatol 2010; 221(3):276-84.
) Lin PT, Krutzik SR, Kim J, Modlin RL. Cutting edge: all-transretinoic acid down-regulates TLR2 expression and function. J Immunol 2005; 174(5): 2467-70.
)Jarrousse V, Castex-Rizzi N, Khammari A, Charveron M, Dréno B. Zinc salts inhibit in vitro Toll-like receptor 2 surface expression by keratinocytes. Eur J Dermatol 2007; (6):492-6.
) Fathy A, Mohamed RW, Ismael NA, El-Akhras MA. Expression of toll-like receptor 2 on peripheral blood monocytes of patients with inflammatory and noninflammatory acne vulgaris. Egypt J Immunol 2009; (1):127-34.
) Kuuliala K, Orpana A, Leirisalo-Repo M, Kautiainen H, Hurme M, Hannonen P, Korpela M, Möttönen T, Paimela L, Puolakka K, Karjalainen A, Repo H. Polymorphism at position +896 of the toll-like receptor 4 gene interferes with rapid response to treatment in rheumatoid arthritis. Ann Rheum Dis 2006; 65(9):1241-3.
) Erridge C, Stewart J and Poxton IR. Monocytes heterozygous for the Asp299Gly and Thr399Ile mutations in the Toll-like receptor 4 gene show no deficit in lipopolysaccharide signalling. J Exp Med 2003; (12):1787–91.
) Von Aulock S, Schroder NW, Gueinzius K, Traub S, Hoffmann S, Graf K, Dimmeler S, Hartung T, Schumann RR and Hermann C. Heterozygous toll-like receptor 4 polymorphism does not influence lipopolysaccharide- induced cytokine release in human whole blood. J Infect Dis ; 188(6): 938–43. ) Van der Graaf C, Kullberg BJ, Joosten L, Verver-Jansen T, Jacobs L, Van der Meer JW and Netea MG. Functional consequences of the Asp299Gly Toll-like receptor-4 polymorphism. Cytokine 2005; 30(5):264–8.
) Van Rijn BB, Roest M, Franx A, Bruinse HW and Voorbij HA. Single step high-throughput determination of Toll-like receptor 4 polymorphisms. J Immunol Methods ; 289(1-2): 81–7. ) Berdeli A, Emingil G, Han Saygan B, Gürkan A, Atilla G, Köse T, Baylas H. TLR2 Arg753Gly, TLR4 Asp299Gly and Thr399Ile gene polymorphisms are not associated with chronic periodontitis in a Turkish population. J Clin Periodontol 2007; 34(7):551–7.
) Schröder NW, Hermann C, Hamann L, Göbel UB, Hartung T, Schumann RR. High frequency of polymorphism Arg753Gln of the Toll-like receptor-2 gene detected by a novel allele-specific PCR. J Mol Med ; 81(6):368-72. )Yoon HJ, Choi JY, Kim CO, Park YS, Kim MS, Kim YK, Shin SY, Kim JM, Song YG. Lack of Toll-like receptor 4 and 2 polymorphisms in Korean patients with bacteremia. J Korean Med Sci 2006; 21(6):979–82.
) Ryu YJ, Kim EJ, Koh WJ, Kim H, Kwon OJ, Chang JH. Toll-like receptor 2 polymorphisms and nontuberculous mycobacterial lung diseases. Clin Vaccine Immunol 2006; 13(7):818–9.
) Paraskevaidis A, Drakoulis N, Roots I, Orfanos CE, Zouboulis CC. Polymorphisms in the human cytochrome P-450 1A1 gene (CYP1A1) as a factor for developing acne. Dermatol 1998; 196(1): 171–5.
) Ostlere LS, Rumsby G, Holownia P, Jacobs HS, Rustin MH, Honour JW. Carrier status for steroid 21- hydroxylase deficiency is only one factor in the variable phenotype of acne. Clin Endocrinol (Oxf) 1998; 48(2): –15.
) Ando I, Kukita A, Soma G, Hino H. A large number of tandem repeats in the polymorphic epithelial mucin gene is associated with severe acne. J Dermatol 1998; 25(3): 150–2.
) He L, Yang Z, Yu H, Cheng B, Tang W, Dong Y, Xiao C. The relationship between CYP17 –34T/C polymorphism and acne in Chinese subjects revealed by sequencing. Dermatol 2006; 212(4): 338–42.
) Pang Y, He CD, Liu Y, Wang KB, Xiao T, Wang YK, Zhu H, Wei B, Zhao N, Jiang Y, Wei HC, Chen HD. Combination of short CAG and GGN repeats in the androgen receptor gene is associated with acne risk in North East China. J Eur Acad Dermatol Venereol 2008; 22(12):1445-51.

There are 34 citations in total.

Details

Primary Language	English
Journal Section	Research Article
Authors	Ebru Onalan Etem This is me İbrahim Kokcam This is me Sevinay Oguz This is me Halit Elyas This is me Yasemin Askın This is me
Publication Date	April 1, 2014
Published in Issue	Year 2014 Volume: 11 Issue: 1

Cite

Vancouver	Etem EO, Kokcam İ, Oguz S, Elyas H, Askın Y. Investigation of Association Between Tlr2 And Tlr4 Gene Polymorphisms and Acne in Turkish Subjects. Harran Üniversitesi Tıp Fakültesi Dergisi. 2014;11(1):1-9.

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Harran Üniversitesi Tıp Fakültesi Dergisi _/Journal of Harran University Medical Faculty