Human papilloma virüs aşılarına genel bakış

Year 2012, Volume: 9 Issue: 2, 68 - 70, 01.08.2012

Adnan İncebıyık

Abstract

Serviks kanseri kadınlarda meme kanserinde sonra ikinci sıklıkta görülen kanser türüdür. Her yıl dünya genelinde yaklaşık 500.000 yeni kanser vakası saptanmakta ve bunların yarısına yakını ölmektedir. Serviks kanseri ile human papilloma virüs HPV arasındaki ilişkinin saptanmasının ardından hem profilaktik hem de hastalığı tedavi edici aşı bulunmasına yönelik çalışmalar hızlanmıştır. 2006 yılında HPV tip 6-11-16-18 L1 kapsid antijeni içeren bir kuadrivalan aşı, 2007 yılında HPV tip 16-18 L1 kapsid antijeni içeren bir bivalan aşı piyasaya sürülmüştür. HPV aşıları HPV'nin dört tipine karşı koruyucu antikor oluşturabilmektedir. Yapılan çalışmalarda aşıların güvenli, iyi tolere edilebilir, serviks kanseri öncü lezyonları ve serviks kanserine karşı koruyucu olduğu yönünde bulgular saptanmıştır. HPV aşılarının 926 yaş aralığında ve mümkünse ilk cinsel temastan önce yapılması önerilmektedir. Profilaktik aşı serviks kanserine karşı koruyucu olsa da aşı yapıldıktan sonra serviks kanseri tarama yöntemlerine devam edilmelidir

Keywords

Serviks kanseri, human papilloma virüs, aşılama

Human Papılloma Virus Vaccines: Overvıew

Abstract

Cervical cancer is the second common form of cancer in women after the breast cancer. Each year, approximately 500,000 new cases of cancer worldwide recognize and nearly half of them die. After detection of the relationship between cervical cancer and human papilloma virus HPV studies both the prophylactic and therapeutic vaccine was accelerated. In 2006, a quadrivalent HPV 6-11-16-18 vaccine containing L1 capsid antigen, in 2007, a bivalent vaccine containing HPV 16-18 L1 capsid antigen were released. HPV vaccines produce protect antibodies against four types of HPV. Vaccines are safe and well tolerated, and leading lesions of cervical cancer and cervical cancer can be prevented. HPV vaccines are recommended in the possible range of 9-26 years, and especially before the first sexual contact. Although the prophylactic vaccine protective against cervical cancer, cervical cancer screening should be continued after vaccinations

Keywords

Cervical cancer, human papilloma virus, vaccination

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