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Atopik dermatit otoimmün bir hastalık mıdır?

Year 2011, Volume: 8 Issue: 3, 89 - 91, 01.12.2011

Abstract

Amaç: Atopik dermatitli hastaların serumlarında, kendi proteinlerine karşı IgE tabiatında otoantikorlar saptanmıştır. IgE otoantikorların, atopik dermatit'in patogenezindeki rolleri tam olarak bilinmemektedir. Çalışmamızda, atopik dermatitli hastalar ile sağlıklı bireylere otolog serum deri testi uygulandı ve sonuçlar değerlendirildi. Materyal ve Metod: Atopik dermatitli hastalar ve kontrol grubundaki sağlıklı bireylerin sağ önkol fleksör yüzlerine otolog serum ve serum fizyolojik uygulandı. Bulgular: Atopik dermatitli hastaların %70'inde ve kontrol grubunun %16,7'sinde otolog serum deri testini pozitif olarak saptadık. Atopi anamnezi olan atopik dermatitli hastaların %67,7'sinde otolog serum deri testini pozitif olarak tespit etik. Atopi anamnezi olmayan atopik dermatitli hastalarda bu oran %65,5 düzeyindeydi. SCORAD indeksine göre orta şiddetteki atopik dermatitli hastaların %72'sinde otolog serum deri testini pozitif olarak saptanırken hafif şiddetteki atopik dermatitli hastaların %60'ında otolog serum deri testini pozitif olarak saptadık. Serum total IgE düzeyleri yüksek olan atopik dermatitli hastaların %72,7'sinde otolog serum deri testi pozitif olarak gözlenirken, serum total IgE düzeyleri düşük olan atopik dermatitli hastaların %66,7'sinde otolog serum deri testini pozitif olarak gözlemlendi.Sonuç: Çalışmamızda otolog serum deri testini atopik dermatitli hastaların %70'ninde otolog serum deri testini pozitif olarak saptadık. Atopi anamnezi bulunan atopik dermatitli hastalar, SOCRAD indeksine göre orta şiddetteki hastalar ile serum total IgE düzeyleri yüksek olan atopik dermatitli hastalarda otolog serum deri testinin pozitifliğini yüksek olarak tespit ettik

References

  • ) Altrichter S, Kriehuber E, Moser J, et al. Serum IgE Autoantibodies Target Keratinocytes in Patients with Atopic Dermatitis. J Invest Dermatol ; 28(9): 2232-2239.
  • ) Leung DY, Jain N, Leo HL. New concepts in the pathogenesis of atopic dermatitis. Current Opinion in Immunology 2003; 15: 634-638.
  • ) Yu B, Shao Y, Zhang J, et al. Polymorphisms in human histamine receptor H4 gene are associated with atopic dermatitis. Br J Dermatol ; 162(5): 1038-1043.
  • ) Valenta R, Maurer D, Steiner R, et al. Immunoglobulin E response to human proteins in atopic patients. J Invest Dermatol 1996; 107(2): 208.
  • ) Natter S, Seiberler S, Hufnagl P, et al. Isolation of cDNA clones coding for IgE autoantigens with serum IgE from atopic dermatitis patients. FASEB J 1998; 12(14): 1559-1569.
  • ) Flückiger S, Scapozza L, Mayer C, et al. Immunological and structural analysis of IgE- mediated cross-reactivity between manganese superoxide dismutases. Int Arch Allergy Immunol ; 128(4): 292-303. ) Mittermann I, Aichberger KJ, Bünder R, et al. A autoimmunity and atopic dermatitis. Curr Opin Allergy Clin Immunol 2004; 4(5): 367-371.
  • ) Godse KV. Autologous serum skin test v/s autologous plasma skin test. Indian J Dermatol Venereol Leprol 2008; 74: 496-497.
  • ) Carr WW. İmprovements in skin-testing technique. Allergy Asthma Pro 2006; 27: 100-103.
  • ) Konstantinou GN, Asero R, Marer M, et l. EAACI/GA(2)LEN task force consensus report: the autologous serum skin test in urticaria. Allergy ; 64(9): 1256-1268.
  • ) Zeller S, Rhyner C, Meyer N, et al. Exploring the repertoire of IgE-binding self-antigens associated with atopic eczema J Allergy Clin Immunol 2009; 124(2): 278-285
  • ) Nomura T, Sandilands A, Akiyama M, et al. Unique mutations in the filaggrin gene in Japanese patients with ichthyosis vulgaris and atopic dermatitis. J Allergy Clin Immunol 2007; : 434-440.
  • ) Schmid-Grendelmeier P, Fluckiger S, Disch R, et al. IgE-mediated and T cell-mediated autoimmunity against manganese superoxide dismutase in atopic dermatitis. J Allergy Clin Immunol 2005; 115: 1068-1075.
  • ) Valenta R, Natter S, Seiberler S, et al. Molecular characterization of an autoallergen, Hom s1, identified by serum IgE from atopic dermatitis patients. J Invest Dermatol 1998; 111: 1178-1183.
  • ) Muro Y. Autoantibodies in atopic dermatitis. J Dermatol Sci 2001; 25(3): 171-178.
  • ) Aichberger KJ, Mittermann I, Reininger R, et al. Hom s 4, an IgE-reactive autoantigen belonging to a new subfamily of calcium-binding proteins, can induce Th cell type 1-mediated autoreactivity. J Immunol 2005; 175(2): 1286-1294.
  • Bieber T. Atopic dermatitis. Ann Dermatol 2010; (2): 125-137.
  • ) Bonness S, Bieber T. Molecular basis of atopic dermatitis. Curr Opin Allergy Clin Immunol 2007; (5): 382-386.
  • ) Mothes N, Niggemann B, Jenneck C, et al. The cradle of IgE autoreactivity in atopic eczema lies in early infancy. J Allergy Clin Immunol 2005; 116: 709.
  • ) Terui T. Analysis of the Mechanism for the Development of Allergic Skin Inflammation and the Application for Its Treatment: Overview of the Pathophysiology of Atopic Dermatitis. J Pharmacol Sci 2009; 110(3): 232-236. P value Atopy ,464 Positive atopy (n=31) %67.7 Negative atop SCORAD index %65.5 ,474 Moderate (n=50) %72 Mild (n=10) %60 Total IgE level ,612
  • High total IgE level (n=33) %72.7 Low total IgE level (n=27) %66.7

Is Atopic Dermatitis an Autoimmune Disease?

Year 2011, Volume: 8 Issue: 3, 89 - 91, 01.12.2011

Abstract

Background: IgE-type autoantibodies against self proteins have been detected in serum of the patients with atopic dermatitis AD . The role of this IgE autoantibodies involved in the pathogenesis of AD remain unclear. The autologus serum skin testing is applied to both AD patients and healthy control and the results are evaluated in our study. Methods: Autologous serum and normal saline are applied to the volar surface of right forearm of all the study groups. Results: The autologous serum skin testing is evaluated positive in 70% of the AD patients and 16.7% of the control group. The test was 67.7% positive in AD patients with a history of atopy whereas 65.5% postive in patients with a negative atopy history. The moderately severe AD patients according to SCORAD scoring system showed 72% positivity on the other hand the test was positive in 60% of the mildly severe AD patients. Test was positive in 72.7% of patients with high serum IgE and 66.7% in patients with low serum IgE. Conclusion: We detected 70% positive autologus serum skin testing in AD patients and test positivity was found higher in patients with atopy history, moderately severe disease calculated by SCORAD index and high serum IgE levels.

References

  • ) Altrichter S, Kriehuber E, Moser J, et al. Serum IgE Autoantibodies Target Keratinocytes in Patients with Atopic Dermatitis. J Invest Dermatol ; 28(9): 2232-2239.
  • ) Leung DY, Jain N, Leo HL. New concepts in the pathogenesis of atopic dermatitis. Current Opinion in Immunology 2003; 15: 634-638.
  • ) Yu B, Shao Y, Zhang J, et al. Polymorphisms in human histamine receptor H4 gene are associated with atopic dermatitis. Br J Dermatol ; 162(5): 1038-1043.
  • ) Valenta R, Maurer D, Steiner R, et al. Immunoglobulin E response to human proteins in atopic patients. J Invest Dermatol 1996; 107(2): 208.
  • ) Natter S, Seiberler S, Hufnagl P, et al. Isolation of cDNA clones coding for IgE autoantigens with serum IgE from atopic dermatitis patients. FASEB J 1998; 12(14): 1559-1569.
  • ) Flückiger S, Scapozza L, Mayer C, et al. Immunological and structural analysis of IgE- mediated cross-reactivity between manganese superoxide dismutases. Int Arch Allergy Immunol ; 128(4): 292-303. ) Mittermann I, Aichberger KJ, Bünder R, et al. A autoimmunity and atopic dermatitis. Curr Opin Allergy Clin Immunol 2004; 4(5): 367-371.
  • ) Godse KV. Autologous serum skin test v/s autologous plasma skin test. Indian J Dermatol Venereol Leprol 2008; 74: 496-497.
  • ) Carr WW. İmprovements in skin-testing technique. Allergy Asthma Pro 2006; 27: 100-103.
  • ) Konstantinou GN, Asero R, Marer M, et l. EAACI/GA(2)LEN task force consensus report: the autologous serum skin test in urticaria. Allergy ; 64(9): 1256-1268.
  • ) Zeller S, Rhyner C, Meyer N, et al. Exploring the repertoire of IgE-binding self-antigens associated with atopic eczema J Allergy Clin Immunol 2009; 124(2): 278-285
  • ) Nomura T, Sandilands A, Akiyama M, et al. Unique mutations in the filaggrin gene in Japanese patients with ichthyosis vulgaris and atopic dermatitis. J Allergy Clin Immunol 2007; : 434-440.
  • ) Schmid-Grendelmeier P, Fluckiger S, Disch R, et al. IgE-mediated and T cell-mediated autoimmunity against manganese superoxide dismutase in atopic dermatitis. J Allergy Clin Immunol 2005; 115: 1068-1075.
  • ) Valenta R, Natter S, Seiberler S, et al. Molecular characterization of an autoallergen, Hom s1, identified by serum IgE from atopic dermatitis patients. J Invest Dermatol 1998; 111: 1178-1183.
  • ) Muro Y. Autoantibodies in atopic dermatitis. J Dermatol Sci 2001; 25(3): 171-178.
  • ) Aichberger KJ, Mittermann I, Reininger R, et al. Hom s 4, an IgE-reactive autoantigen belonging to a new subfamily of calcium-binding proteins, can induce Th cell type 1-mediated autoreactivity. J Immunol 2005; 175(2): 1286-1294.
  • Bieber T. Atopic dermatitis. Ann Dermatol 2010; (2): 125-137.
  • ) Bonness S, Bieber T. Molecular basis of atopic dermatitis. Curr Opin Allergy Clin Immunol 2007; (5): 382-386.
  • ) Mothes N, Niggemann B, Jenneck C, et al. The cradle of IgE autoreactivity in atopic eczema lies in early infancy. J Allergy Clin Immunol 2005; 116: 709.
  • ) Terui T. Analysis of the Mechanism for the Development of Allergic Skin Inflammation and the Application for Its Treatment: Overview of the Pathophysiology of Atopic Dermatitis. J Pharmacol Sci 2009; 110(3): 232-236. P value Atopy ,464 Positive atopy (n=31) %67.7 Negative atop SCORAD index %65.5 ,474 Moderate (n=50) %72 Mild (n=10) %60 Total IgE level ,612
  • High total IgE level (n=33) %72.7 Low total IgE level (n=27) %66.7
There are 20 citations in total.

Details

Primary Language Turkish
Journal Section Research Article
Authors

Yavuz Yesilova This is me

Seval Dogruk Kacar This is me

Publication Date December 1, 2011
Published in Issue Year 2011 Volume: 8 Issue: 3

Cite

Vancouver Yesilova Y, Kacar SD. Atopik dermatit otoimmün bir hastalık mıdır?. Harran Üniversitesi Tıp Fakültesi Dergisi. 2011;8(3):89-91.

Harran Üniversitesi Tıp Fakültesi Dergisi  / Journal of Harran University Medical Faculty