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Koma Ve Konvülziyon İle Getirilen Akut İzoniazid Zehirlenmesi

Year 2009, Volume: 6 Issue: 1, 47 - 48, 01.04.2009

Abstract

Amaç: Konvülziyon ve koma ile gelen akut izoniazid zehirlenmesi olan olguyu sunmak amaçlandı. Olgu: Proflaksi amaçlı başlanan izoniazid tabletlerden 100mg/tb 10 tane alan 8 yaşındaki erkek olgu sunuldu. Beslenme sondası aracılığı ile olguya mide lavajı yapıldı. Mide lavajı sonrasında olguya aktif kömür uygulandı. Acile getirildiği sırada konvülzyonu başlayan olguya diazepam uygulandı ve konvülzyonu 5. dakikada durdu. Antidot olarak Pridoksin 1.5 gr 50 mg/kg/gün intravenöz olarak uygulandı. 8 saatlik takip sonrası hastanın bilinci açıldı. Genel durumu düzeldi. Oral beslenmeye başladı Sonuç: İzoniazid zehirlenmesinde konvülziyonun tedavisinde en iyi yol Pridoksin uygulanmasıdır

References

  • Citak A, Kaya O, Ucsel R, Karabocuoglu M, Uzel N. Acute isoniazid neurotoxicity in childhood. Turk J Pediatr 2002;44:54-7.
  • Temmerman W, Dhondt A, Vandewoude K. Acute isoniazid intoxication: seizures, acidosis and coma. Acta Clin Belg. 1999;54:211-6.
  • Okutur SK, Borlu F, Ersoy CY, Paksoy F. Acute Isoniazid Rhabdomyolysis and Metabolic Acidosis. Turk J Med Sci 2006; 36: 397-399.
  • Romero JA, Kuczler FJ. Isoniazid overdose. Recognition and management. Am Fam Physician ; 57: 749-752. Miller J, Robinson A, Percy AK. Acute isoniazid poisoning in childhood. Am J Dis Child ; 134: 290-292. Ozmenoglu M, Bolukbası O, Mocan H, Bulut F. Acute Isoniazid Poisoning Presenting As Seizures. ;31:63-65. Turkmen A, Ersoy A, Atlan A, Turgut N, Ervatan Z, Kızılırmak S. Acute isoniaside intoxication. ;20:51-53
  • Brown A, Mallett M, Fiser D, Arnold WC. Acute isoniazid intoxication: reversal of CNS symptoms with large doses of pyridoxine. Pediatr Pharmacol 1984;4:199-202. Convulsion, Archives of Neuropsychiatry Medical Journal of Goztepe
  • Corresponding Address: Alpay Cakmak, MD Harran University School of Medicine Department of Pediatrics TR-63100, Sanliurfa, TURKEY. Tel: +90 414 3141170 Mobile Phone : +90 5326235956 e-mail: alpaycakmak@gmail.com Fax: +90 414 3151181

Acute Isoniazid Poisoning Presenting With Convulsions And Coma

Year 2009, Volume: 6 Issue: 1, 47 - 48, 01.04.2009

Abstract

Purpose: We report a case of acute isoniazid intoxication presented with convulsions, and coma. Case: An 8-year-old boy had taken 10 isoniazid tablets 100mg/tb which had been started as a prophylactic. A nasogastric catheter was administered and gastric lavage was performed followed by the administration of activated charcoal. Immediately after the procedure, sudden convulsions began, which subsided within five minutes of the administration of diazepam infusion. As an antidote, Pyridoxine 1.5 gr 50 mg/kg/day ,was administered intravenously. After 8 hours the patient regained consciousness, his general condition normalized and oral nutrition was started. Conclusions: Pyridoxine administration is the best way of treating convulsions. Parenteral pyridoxine administration is an effective method in isoniazid intoxication

References

  • Citak A, Kaya O, Ucsel R, Karabocuoglu M, Uzel N. Acute isoniazid neurotoxicity in childhood. Turk J Pediatr 2002;44:54-7.
  • Temmerman W, Dhondt A, Vandewoude K. Acute isoniazid intoxication: seizures, acidosis and coma. Acta Clin Belg. 1999;54:211-6.
  • Okutur SK, Borlu F, Ersoy CY, Paksoy F. Acute Isoniazid Rhabdomyolysis and Metabolic Acidosis. Turk J Med Sci 2006; 36: 397-399.
  • Romero JA, Kuczler FJ. Isoniazid overdose. Recognition and management. Am Fam Physician ; 57: 749-752. Miller J, Robinson A, Percy AK. Acute isoniazid poisoning in childhood. Am J Dis Child ; 134: 290-292. Ozmenoglu M, Bolukbası O, Mocan H, Bulut F. Acute Isoniazid Poisoning Presenting As Seizures. ;31:63-65. Turkmen A, Ersoy A, Atlan A, Turgut N, Ervatan Z, Kızılırmak S. Acute isoniaside intoxication. ;20:51-53
  • Brown A, Mallett M, Fiser D, Arnold WC. Acute isoniazid intoxication: reversal of CNS symptoms with large doses of pyridoxine. Pediatr Pharmacol 1984;4:199-202. Convulsion, Archives of Neuropsychiatry Medical Journal of Goztepe
  • Corresponding Address: Alpay Cakmak, MD Harran University School of Medicine Department of Pediatrics TR-63100, Sanliurfa, TURKEY. Tel: +90 414 3141170 Mobile Phone : +90 5326235956 e-mail: alpaycakmak@gmail.com Fax: +90 414 3151181
There are 6 citations in total.

Details

Primary Language English
Journal Section Research Article
Authors

Alpay Cakmak This is me

Ali Atas This is me

Mustafa Soran This is me

Dost Zeyrek This is me

Publication Date April 1, 2009
Published in Issue Year 2009 Volume: 6 Issue: 1

Cite

Vancouver Cakmak A, Atas A, Soran M, Zeyrek D. Acute Isoniazid Poisoning Presenting With Convulsions And Coma. Harran Üniversitesi Tıp Fakültesi Dergisi. 2009;6(1):47-8.

Harran Üniversitesi Tıp Fakültesi Dergisi  / Journal of Harran University Medical Faculty