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Laparoskopik Sleeve Gastrektomi Yapılan Hastaların Patoloji Spesmenlerinde Rastlantısal Gastro İntestinal Stromal Tümör Saptama Oranımız

Year 2024, Volume: 21 Issue: 2, 201 - 205, 29.08.2024
https://doi.org/10.35440/hutfd.1491256

Abstract

Amaç: Kliniğimizde morbid obezite nedeniyle laparoskopik sleeve gastrektomi (LSG) uygulanan hastalarda rastlantısal gastrointestinal stromal tümör (gıst) olgularımızı sunmayı amaçladık
Materyal ve Metod: Kliniğimizde Ocak 2015 ile Kasım 2023 tarihleri arasında tek genel cerrahi uzmanı tarafından yapılan 743 LSG olgusu retrospektif olarak incelendi. Bu hastaların patoloji raporları değerlendirildi.
Bulgular: 743 hastanın patoloji raporları incelendiğinde 4 olguda GIST saptandı (%0.54). Bu 4 olguda da cerrahi esnasında lezyonlar görüldü ve GIST' den şüphelenildi.
Sonuç: GIST normal popülasyonda oldukça nadirdir. LSG operasyonunun daha geniş bir şekilde yapılmaya başlanmasıyla morbid obez hastalarda görülen GIST oranı normal popülasyondan daha fazla gözlenmektedir. Çalışmamızda belirlenen oranın literatür ile uyumlu olduğu görüldü (%0.3-1.2).

References

  • 1. Erdem H, Gencturk M, Emir S, Sisik A, Sozen S. Incidental detection of gastrointestinal stromal tumors during lapa-roscopic sleeve gastrectomy. What to do? Ann Ital Chir. 2022;93:536-43.
  • 2. Dowgiałło-Gornowicz N, Sztaba K, Lech P, Botulińska A, Michalik M. The Incidence of Gastrointestinal Stromal Tu-mors in Obese Patients-A Large Single Center Experience. Medicina (Kaunas). 2021:14;57(11):1242.
  • 3. Ünver B, Yılmaz S, Taş S. Diz osteoartritli hastalarda klinik semptomlar, yaş, cinsiyet, vücut kitlesi ve radyolojik şiddet arasındaki ilişkinin araştırılması. Turk J Physiother Reha-bil 2015;26:9.
  • 4. Sevinçer Güzin M. "Türkiye'de obezite cerrahisinin psikiyat-rik yönetimi: fikir birliği ve kılavuz ihtiyacı/Türkiye'de obezi-te cerrahisinde psikiyatrik değerlendirme: Uzlasma ve kila-vuz gereksinmesi." Anadolu Psikiyatri Dergisi 2016;17:2-15.
  • 5. Juodeikis Z, Brimas G. "Tüp mide ameliyatı sonrası uzun vadeli sonuçlar: sistematik bir inceleme", Obezite ve İlgili Hastalıklar Cerrahisi 2017;13:693-9.
  • 6. Lazzati A, Guy-Lachuer R, Delaunay V et al. Bariatric surgery trends in France: 2005-2011. Surg Obes Relat Dis 2014;10(2):328- 34.
  • 7. AlAli MN, Bamehriz F, Arishi H, Aldeghaither MK, Alabdul-latif F, Alnaeem KA, et al. Trends in bariatric surgery and incidentalomas at a single institution in Saudi Arabia: a ret-rospective study and literature review. Ann Saudi Med. 2020;40(5):389-95.
  • 8. Viscido G, Signorini F, Navarro L, Campazzo M, Saleg P, Gorodner V, et al. Incidental Finding of Gastrointestinal Stromal Tumors during Laparoscopic Sleeve Gastrectomy in Obese Patients. Obes Surg. 2017;27(8):2022-5.
  • 9. Sawalmeh H, Makhdoom M, Khammas A. Incidental finding of Gastrointestinal Stromal Tumors (GISTs) during Laparos-copic Sleeve Gastrectomy: A case report and literature re-view. Pulsus J Surg Res. 2019;3(1):87- 9.
  • 10. Crouthamel MR, Kaufman JA, Billing JP, Billing PS, Lander-holm RW. Incidental gastric mesenchymal tumors identi-fied during laparoscopic sleeve gastrectomy. Surg Obes Re-lat Dis. 2015;11(5):1025-8.
  • 11. Hashimoto K, Sakaguchi Y, Nambara S, Kudou K, Kusumoto E, Yoshinaga K et al. Laparoscopic sleeve gastrectomy per-formed in a morbidly obese patient with gastrointestinal stromal tumor: a case report and literature review. Surg Case Rep. 2020;6(1):208.
  • 12. Kasapoğlu B, Türkay C. Gastrointestinal Stromal Tümör-ler. Güncel Gastroenteroloji Dergisi, 2008;12(2):106-10.
  • 13. Fletcher CDM, Berman JJ, Corless C ve diğerleri. Gastroin-testinal Stromal Tümörlerin Tanısı: Konsensüs Yaklaşımı. Uluslararası Cerrahi Patoloji Dergisi. 2002;10(2):81-9.
  • 14. Chiappetta S, Theodoridou S, Stier C et al. Incidental finding of GIST during obesity surgery. Obes Surg. 2015;25(3):579–83.
  • 15. Machado I, Claramunt-Alonso R, Lavernia J, Romero I, Bar-rios M, Safont MJ et al. ETV6::NTRK3 Fusion-Positive Wild-Type Gastrointestinal Stromal Tumor (GIST) with Abundant Lymphoid Infiltration (TILs and Tertiary Lymphoid Structu-res): A Report on a New Case with Therapeutic Implications and a Literature Review. Int J Mol Sci. 2024;25(7):3707.
  • 16. Yuval JB, Khalaileh A, Abu-Gazala M et al. The True Inciden-ce of Gastric GIST—a Study Based on Morbidly Obese Pati-ents Undergoing Sleeve Gastrectomy. Obes Surg Obes Surg. 2014;24(12):2134-7.
  • 17. Sanchez BR, Morton JM, Curet MJ et al. Incidental Finding of Gastrointestinal Stromal Tumors (GISTs) during Laparos-copic Gastric Bypass. Obes Surg 2005;15: 1384–8.
  • 18. Hallak YO, Karajeh O, Rivas H et al. Incidental Gastrointes-tinal Stromal Tumors (GIST) During Laparoscopic Sleeve Gastrectomy Procedures: a Retrospective Study. Obes Surg. 2022;32:3–7.
  • 19. Ferig M, Alarcon Velasco S, Van Doren L, Saif MW. Gastro-intestinal Stromal Tumors Incidentalomas: A Case Series. Cancer Med J. 2020;3(1):35-8.

Our Incidental Gastro Intestinal Stromal Tumor Detection rate in pathology Specimens of Patients Who Had Laparoscopic Sleeve Gastrectomy

Year 2024, Volume: 21 Issue: 2, 201 - 205, 29.08.2024
https://doi.org/10.35440/hutfd.1491256

Abstract

Background: In this study, we discussed the incidental detection of Gastro Intestinal Stromal Tumor (GIST) in patients who underwent Laparoscopic Sleeve Gastrectomy (LSG) operation in our hospital.
Materials and Methods: We retrospectively analyzed the data of 743 patients operated on by a single surgeon in our clinic between January 2015 and November 2023. The pathology reports of these patients were examined.
Results: When the pathology reports of 743 patients were examined, GIST was detected inciden-tally in 4 patients (0.54%). These patients had lesions that were noticed during surgery and were suspicious for GIST.
Conclusions: GIST is very rare in the normal population. With the widespread use of LSG opera-tion, it has been observed that the rate of GIST is much higher in the morbidly obese patient population than in the normal population. The rate determined in our study was found to be compatible with the general literature (0.3-1.2%).

Key Words: Pathology, GIST, Morbid obesity, Sleeve gastrectomy

References

  • 1. Erdem H, Gencturk M, Emir S, Sisik A, Sozen S. Incidental detection of gastrointestinal stromal tumors during lapa-roscopic sleeve gastrectomy. What to do? Ann Ital Chir. 2022;93:536-43.
  • 2. Dowgiałło-Gornowicz N, Sztaba K, Lech P, Botulińska A, Michalik M. The Incidence of Gastrointestinal Stromal Tu-mors in Obese Patients-A Large Single Center Experience. Medicina (Kaunas). 2021:14;57(11):1242.
  • 3. Ünver B, Yılmaz S, Taş S. Diz osteoartritli hastalarda klinik semptomlar, yaş, cinsiyet, vücut kitlesi ve radyolojik şiddet arasındaki ilişkinin araştırılması. Turk J Physiother Reha-bil 2015;26:9.
  • 4. Sevinçer Güzin M. "Türkiye'de obezite cerrahisinin psikiyat-rik yönetimi: fikir birliği ve kılavuz ihtiyacı/Türkiye'de obezi-te cerrahisinde psikiyatrik değerlendirme: Uzlasma ve kila-vuz gereksinmesi." Anadolu Psikiyatri Dergisi 2016;17:2-15.
  • 5. Juodeikis Z, Brimas G. "Tüp mide ameliyatı sonrası uzun vadeli sonuçlar: sistematik bir inceleme", Obezite ve İlgili Hastalıklar Cerrahisi 2017;13:693-9.
  • 6. Lazzati A, Guy-Lachuer R, Delaunay V et al. Bariatric surgery trends in France: 2005-2011. Surg Obes Relat Dis 2014;10(2):328- 34.
  • 7. AlAli MN, Bamehriz F, Arishi H, Aldeghaither MK, Alabdul-latif F, Alnaeem KA, et al. Trends in bariatric surgery and incidentalomas at a single institution in Saudi Arabia: a ret-rospective study and literature review. Ann Saudi Med. 2020;40(5):389-95.
  • 8. Viscido G, Signorini F, Navarro L, Campazzo M, Saleg P, Gorodner V, et al. Incidental Finding of Gastrointestinal Stromal Tumors during Laparoscopic Sleeve Gastrectomy in Obese Patients. Obes Surg. 2017;27(8):2022-5.
  • 9. Sawalmeh H, Makhdoom M, Khammas A. Incidental finding of Gastrointestinal Stromal Tumors (GISTs) during Laparos-copic Sleeve Gastrectomy: A case report and literature re-view. Pulsus J Surg Res. 2019;3(1):87- 9.
  • 10. Crouthamel MR, Kaufman JA, Billing JP, Billing PS, Lander-holm RW. Incidental gastric mesenchymal tumors identi-fied during laparoscopic sleeve gastrectomy. Surg Obes Re-lat Dis. 2015;11(5):1025-8.
  • 11. Hashimoto K, Sakaguchi Y, Nambara S, Kudou K, Kusumoto E, Yoshinaga K et al. Laparoscopic sleeve gastrectomy per-formed in a morbidly obese patient with gastrointestinal stromal tumor: a case report and literature review. Surg Case Rep. 2020;6(1):208.
  • 12. Kasapoğlu B, Türkay C. Gastrointestinal Stromal Tümör-ler. Güncel Gastroenteroloji Dergisi, 2008;12(2):106-10.
  • 13. Fletcher CDM, Berman JJ, Corless C ve diğerleri. Gastroin-testinal Stromal Tümörlerin Tanısı: Konsensüs Yaklaşımı. Uluslararası Cerrahi Patoloji Dergisi. 2002;10(2):81-9.
  • 14. Chiappetta S, Theodoridou S, Stier C et al. Incidental finding of GIST during obesity surgery. Obes Surg. 2015;25(3):579–83.
  • 15. Machado I, Claramunt-Alonso R, Lavernia J, Romero I, Bar-rios M, Safont MJ et al. ETV6::NTRK3 Fusion-Positive Wild-Type Gastrointestinal Stromal Tumor (GIST) with Abundant Lymphoid Infiltration (TILs and Tertiary Lymphoid Structu-res): A Report on a New Case with Therapeutic Implications and a Literature Review. Int J Mol Sci. 2024;25(7):3707.
  • 16. Yuval JB, Khalaileh A, Abu-Gazala M et al. The True Inciden-ce of Gastric GIST—a Study Based on Morbidly Obese Pati-ents Undergoing Sleeve Gastrectomy. Obes Surg Obes Surg. 2014;24(12):2134-7.
  • 17. Sanchez BR, Morton JM, Curet MJ et al. Incidental Finding of Gastrointestinal Stromal Tumors (GISTs) during Laparos-copic Gastric Bypass. Obes Surg 2005;15: 1384–8.
  • 18. Hallak YO, Karajeh O, Rivas H et al. Incidental Gastrointes-tinal Stromal Tumors (GIST) During Laparoscopic Sleeve Gastrectomy Procedures: a Retrospective Study. Obes Surg. 2022;32:3–7.
  • 19. Ferig M, Alarcon Velasco S, Van Doren L, Saif MW. Gastro-intestinal Stromal Tumors Incidentalomas: A Case Series. Cancer Med J. 2020;3(1):35-8.
There are 19 citations in total.

Details

Primary Language Turkish
Subjects General Surgery
Journal Section Research Article
Authors

Hasan Elkan 0000-0003-3781-7527

Mehmet Sait Berhuni 0000-0003-4617-069X

Muhammet Emin Güldür 0000-0002-6568-3362

Vedat Kaplan 0000-0002-9389-4351

Faik Tatlı 0000-0002-7488-1854

Early Pub Date August 7, 2024
Publication Date August 29, 2024
Submission Date May 29, 2024
Acceptance Date July 18, 2024
Published in Issue Year 2024 Volume: 21 Issue: 2

Cite

Vancouver Elkan H, Berhuni MS, Güldür ME, Kaplan V, Tatlı F. Laparoskopik Sleeve Gastrektomi Yapılan Hastaların Patoloji Spesmenlerinde Rastlantısal Gastro İntestinal Stromal Tümör Saptama Oranımız. Harran Üniversitesi Tıp Fakültesi Dergisi. 2024;21(2):201-5.

Harran Üniversitesi Tıp Fakültesi Dergisi  / Journal of Harran University Medical Faculty