Veteriner Hekimlikte İmmünokontrasepsiyon

Year 2022, , 263 - 268, 30.12.2022

Anıl Gürkan Aksu , Serhan Serhat Ay

https://doi.org/10.31196/huvfd.1153097

Abstract

Hayvan popülasyonundaki kontrolsüz artış üremenin denetlenmesi konusunu daha da önemli hale getirmiştir. Tüm dünyada kontrasepsiyon amacıyla halen kullanılmakta olan cerrahi ve hormonal yöntemlerin birçok dezavantajı bulunmaktadır. İmmünokontrasepsiyon bu dezavantajları ortadan kaldırmak amacıyla yeni bir kontrasepsiyon yöntemi olarak düşünülmüştür. Görevi çeşitli etkenlere karşı vücudu korumak olan immün sistemin fizyolojik tolerans etkisi gebeliğin devam etmesini sağlamaktadır. İmmünokontrasepsiyon ile immün sistemin bu etkisi tersine çevrilerek gebelik ile sonuçlanan reprodüktif süreci bozmaktadır. Farklı deyişle immün sistemin vücudun kendi reprodüktif sürecinde belli aşamalara/dokulara saldırması ile sağlanmaktadır. Bunun için bir antijen-antikor kompleksinin oluşturulması gereklidir. 1970’li yıllardan bu yana çalışılmakta olan immünokontraseptiyon alanında hali hazırda zona pelusida (ZP), gonadotropin salgılatıcı hormon (GnRH) ve lüteinleştirici hormon (LH) reseptörlerine karşı aşılamalar geliştirilmiştir. Sunulan derleme immünokontrasepsiyon ve günümüzde kullanılan aşılar hakkındaki bilgilerin güncellenmesi amacıyla hazırlanmıştır.

Keywords

GnRH aşısı, Üremenin denetlenmesi, İmmünokontrasepsiyon, ZP aşısı

References

• Asa CS, 2018: Contraception in dogs and cats. Vet Clin North Am Small Anim Pract, 48 (4), 733-742.
• Barber MR, Fayrer-Hosken RA, 2000: Possible mechanisms of mammalian immunocontraception. J Reprod Immunol, 46 (2), 103-124.
• Curtis PD, Richmond ME, Miller LA, Quimby FW, 2008: Physiological effects of gonadotropin-releasing hormone immunocontraception on white-tailed deer. Human- Wildlife Conflicts, 2 (1), 68-79.
• Delsink AK, Kirkpatrick J, Van Altena JJ, Bertschinger HJ, Ferreira SM, Slotow R, 2013: Lack of spatial and behavioral responses to immunocontraception application in African elephants (Loxodonta africana). J Zoo Wildl Med, 44 (4).
• Giriboni J, Lacuesta L, Santiago-Moreno J, Ungerfeld R, 2020: Chronic use of a GnRH agonist (deslorelin) or immunization against GnRH: effects on testicular function and sperm quality of bucks. Domest Anim Endocrinol, 71, 106395.
• Gupta SK, 2022: Zona pellucida glycoproteins: Relevance in fertility and development of contraceptive vaccines. A J Repro Immunol, e13535.
• Gupta SK, Srivastava N, Choudhury S, Rath A, Sivapurapu N, Gahlay GK, Batra D, 2004: Update on zona pellucida glycoproteins based contraceptive vaccine. J Reprod Immunol, 62 (1-2), 79-89.
• Jung MJ, Moon YC, Cho IH, Yeh JY, Kim SE, Chang WS, Lee JB, 2005: Induction of castration by immunization of male dogs with recombinant gonadotropin- releasing hormone (GnRH)-canine distemper virus (CDV) T helper cell epitope p35. J Vet Sci, 6 (1), 21-24
• Katherine M, Linda R, 2013: Contraception and Fertility Control in Dogs and Cats. Portland: Alliance for Conception in Cats and Dogs. Hal, 19-24.
• Khatal GD, Thorat MG, Chepte SD, Fani F A, Deshmukh SG, Bhave NP, Jadhav AA, 2019: Clinical evaluation of right lateral flank and ventral midline approach for ovariohysterectomy in dog. J Entomol Zool Studi 7 (5): 957-960.
• Killian G, Kreeger TJ, Rhyan J, Fagerstone K, Miller L, 2009: Observations on the use of GonaconTM in captive female elk (Cervus elaphus). J Wildl Dis, 45 (1), 184-188.
• Killian G, Miller L, Rhyan J, Doten H, 2006: Immunocontraception of Florida feral swine with a single‐dose GnRH vaccine. A J Repro Immunol, 55 (5), 378-384.
• Kirkpatrick JF, Rutberg AT, Coates-Markle L, Fazio PM, 2012: Immunocontraceptive Reproductive Control Utilizing Porcine Zona Pellucida (PZP) in Federal Wild Horse Populations. Sci Conserv Cent: Bil, MT
• Kirkpatrick JF, Turner A, 2007: Immunocontraception and increased longevity in equids. Zoo Biol: Published in affiliation with the AZA, 26 (4), 237-244.
• Kirkpatrick JF, Turner A, 2008: Achieving population goals in a long-lived wildlife species (Equus caballus) with contraception. Wildl Res, 35 (6), 513-519.
• Kochman K, 2012: Evolution of gonadotropin-releasing hormone (GnRH) structure and its receptor. J Anim Feed Sci, 21 (3), 30.
• Kustritz MVR, 2018: Population control in small animals. Vet Clin Small Anim Pract, 48 (4), 721-732.
• Kutzler M, Wood A, 2006: Non-surgical methods of contraception and sterilization. Theriogenology, 66 (3), 514-525. Levy JK, Miller LA, Crawford PC, Ritchey JW, Ross MK, Fagerstone KA, 2004: GnRH immunocontraception of male cats. Theriogenology, 62 (6), 1116-1130.
• Liu IKM, Bernoco M, Feldman M, 1989: Contraception in mares heteroimmunized with pig zonae pellucidae. Reprod, 85 (1), 19-29.
• Mask TA, Schoenecker KA, Kane AJ, Ransom JI, Bruemmer JE, 2015: Serum antibody immunoreactivity to equine zona protein after SpayVac vaccination. Theriogenology, 84 (2), 261-267
• Meeusen EN, Walker J, Peters A, Pastoret PP, Jungersen G, 2007: Current status of veterinary vaccines. Clin Microbiol Rev, 20 (3), 489-510.
• Moros-Nicolás C, Leza A, Chevret P, Guillén-Martínez A, González-Brusi L, Boué F, Izquierdo-Rico MJ, 2018: Analysis of ZP1 gene reveals differences in zona pellucida composition in carnivores. Reprod Fertil Dev, 30 (2), 272-285.
• Munks MW, 2012: Progress in development of immunocontraceptive vaccines for permanent non‐surgical sterilization of cats and dogs. Reprod Domest Anim, 47, 223-227.
• Munson L. 2006: Contraception in felids. Theriogenology, 66 (1), 126-134.
• Naz RK, Saver AE, 2016: Immunocontraception for animals: current status and future perspective. A J Repro Immunol, 75 (4), 426-439.
• Nuñez CMV, Adelman JS, Rubenstein DI, 2010: Immunocontraception in wild horses (Equus caballus) extends reproductive cycling beyond the normal breeding season. PloS One, 5: 1–10
• Plumb DC, 2002: Veterinary Drug Handbook, 4th ed., Ames, IA Iowa State University Press.
• Ransom JI, Powers JG, Garbe HM, Oehler Sr MW, Nett TM, Baker DL, 2014: Behavior of feral horses in response to culling and GnRH immunocontraception. Appl Anim Behav Sci, 157, 81-92
• Riaz M, Yousaf F, Akram M, Ullah MI, Rasool G, Egbuna C, Ifemeje JC, 2022: J Immunoassay Immunochem. In Analytical Techniques in Biosciences. Academic Press. (pp. 251-268)
• Robbins SC, Jelinski MD, Stotish RL, 2004: Assessment of the immunological and biological efficacy of two different doses of a recombinant GnRH vaccine in domestic male and female cats (Felis catus). J Reprod Immunol, 64 (1-2), 107-119
• Saxena BB, Clavio A, Singh M, Rathnam P, Bukharovich EY, Reimers Jr TJ, Perkins S, 2003: Effect of immunization with bovine luteinizing hormone receptor on ovarian function in cats. Am J Vet Res, 64 (3), 292-298
• Saxena BB, Clavio A, Singh M, Rathnam P, Bukharovich Y, Reimers Jr T, Perkins S, 2002: Modulation of ovarian function in female dogs immunized with bovine luteinizing hormone receptor. Reprod Domest Anim, 37 (1), 9-17.
• Skinner SM, Prasad SV, Ndolo TM, Dunbar BS, 1996: Zona pellucida antigens: targets for contraceptive vaccines. Am J Reprod Immunol, 35 (3), 163-174.
• Soto FRM, Ferreira F, Pinheiro SR, Nogari F, Risseto MR, de Souza O, Amaku M, 2005: Adoption of shelter dogs in a Brazilian community: assessing the caretaker profile. J Appl Anim Welf Sci, 8 (2), 105-116.
• Turner Jr JW, Liu IK, Flanagan DR, Bynum KS, Rutberg AT, 2002: Porcine zona pellucida (PZP) immunocontraception of wild horses (Equus caballus) in Nevada: a 10 year study. Reprod Suppl, 60, 177-186.
• Turvey SE, Broide DH, 2010: Innate immunity. J Allergy Clin Immunol, 125 (2), 24-32.
• Vargas-Pino F, Gutiérrez-Cedillo V, Canales-Vargas EJ, Gress-Ortega LR, Miller LA, Rupprecht CE, Slate D, 2013: Concomitant administration of GonaConTM and rabies vaccine in female dogs (Canis familiaris) in Mexico. Vaccine, 31 (40), 4442- 4447.