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Nörolojik Distemperli Köpeklerin Başlangıç Klinik Görünümü

Year 2023, , 152 - 159, 22.12.2023
https://doi.org/10.31196/huvfd.1310888

Abstract

Kanin distemper virus (CDV), merkezi sinir sistemi içinde demyelinizasyona, gastrointestinal ve/veya respiratorik semptomlara yol açabilir. Çok çeşitli klinik bulguları nedeniyle, farklı yaştaki nörolojik CDV'li köpeklerin başlangıç klinik görünümlerinin belirlenmesi, özellikle triyajda, CDV şüphesi indeksini artırmak için kullanılabilir. Klinik bulguları nörolojik CDV varlığından şüphelendiren 2-8 aylık 44 köpeğin 38'i çalışmaya dahil edildi. Köpekler yaşlarına göre iki alt gruba ayrıldı. Buna göre, 2-4 aylık köpekler Grup 1'e (n:16), 5-8 aylık köpekler Grup 2'ye (n:22) dahil edildi. Grup 1'in vücut sıcaklığı Grup 2'den yüksekti (p<0.000). Ekstranöral bulgular kapsamında ateş, iştahsızlık, depresyon, göz ve burun akıntısı, diyare, üveit ve pnömoni belirlendi. Nöral bulgular arasında davranış değişikliği, kafa sallama, kuadripleji, konvülsiyon, ataksi ve miyoklonus belirlendi. Toraks radyografisinde kranioventral alveoler pulmoner patern ve yaygın interstisyel pnömoni saptandı. Grup 2’de, gastrointestinal sistemde yabancı cisim varlığı dikkat çekiciydi. Toraks ultrasonografisinde her iki grupta da B çizgileri (>3 çizgi) belirgindi. Abdominal ultrasonografide dilate barsak segmentleri gözlendi. İnvaziv olmayan görüntüleme teknikleri ile birlikte başlangıç klinik görünümün değerlendirilmesinin, özellikle triyajda, laboratuvar analizlerine geçmeden önce nörolojik CDV şüphe indeksini artırmak için kullanılabileceği kanısına varıldı.

Supporting Institution

Bulunmamaktadır.

Project Number

Bulunmamaktadır.

Thanks

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References

  • Amude AM, Alfieri AA, Alfieri AF, 2006: The nervous form of canine distemper. Vet e Zootec, 13 (2), 125-136.
  • Amude AM, Alfieri AA, Arias MVB, Alfieri AF, 2012: Clinical syndromes of nervous distemper in dogs initially presented without conventional evidences of CDV infection. Semin Ciênc Agrár, 33 (6), 2347-2358.
  • Amude AM, Alfieri AA, Alfieri AF, 2006: Antemortem diagnosis of CDV infection by RT-PCR in distemper dogs with neurological deficits without the typical clinical presentation. Vet Res Commun, 30 (6), 679.
  • Appel MJ, Mendelson SG, Hall WW, 1984: Macrophage Fc receptors control infectivity and neutralization of canine distemper virus-antibody complexes. J Virol, 51 (3), 643–649.
  • Appel MJ, Shek WR, Summers BA, 1982: Lymphocyte-mediated immune cytotoxicity in dogs infected with virulent canine distemper virus. Infect Immun, 37 (2), 592–600.
  • Appel MJ, Yates RA, Foley GL, Bernstein JJ, Santinelli S, Spelman LH, Miller LD, Arp LH, Anderson M, Barr M, Pearce-Kelling S, Summers BA, 1994: Canine distemper epizootic in lions, tigers, and leopards in North America. J Vet Diagn, 6 (3), 277-288.
  • Braund, 1994 Braund KG, Toivio-Kinnucan M, Vallat JM, Mehta JR, Levesque DC, 1994: Distal sensorimotor polyneuropathy in mature Rottweiler dogs. Vet Pathol, 31 (3), 316-326.
  • Braund KG, 1994: Distemper. In: Clinical Syndromes in Veterinary Neurology. Braund KG (Ed), 115-119, St Louis, Mosby.
  • DeLahunta A, Glass E, 2009: Upper motor neuron. In: Veterinary Neuroanatomy and Clinical Neurology, DeLa-hunta A, Glass E (Eds). 192-229, Elsevier Health Science, St Louis, MO, USA.
  • Dewey CWA, 2008: Pratical Guide To Canine and Feline Neurology. 2nd ed. Wiley-Blackwell, Ames, Iowa, USA.
  • Green EC, Appel MJ, 1990: Canine distemper virus. In: Infections diseases of the dog and cat. Greene CE (Ed), 226-241. WB Saunders Company, Philadelphia, USA.
  • Griot C, Burge T, Vandevelde M, Peterhans E, 1989: Antibody-induced generation of reactive oxygen radicals by brain macrophages in canine distemper encephalitis: a mechanism for bystander demyelination. Acta Neuropathol, 78, 396–403.
  • Gülersoy E, Balıkçı C, Günal İ, Şahan A, 2022: Evaluation of the Efficacy of Blood Gases and Hemogram Parameters in the Diagnosis of non Neurogenic Distemper and Parvoviral Enteritis in Dogs with Acute Gastroenteritis. Rev Cient Fac Cienc Vet, 32.
  • Handl S, Wehr U, Zentek J, Krammer-Lukas S, 2009: Histological and immunohistochemical evaluation of duodenal and colonic biopsies after oral bovine lactoferrin supplementation in beagle puppies. J Anim Physiol Anim Nutr, 93, 76–82. doi: 10.1111/j.1439-0396.2007.00781.x
  • Harjes L, Le Pommellet H, Hostnik E, Rudinsky A, 2018: Resolution of esophageal dysmotility following treatment of nasal disease in a dog. Can Vet J, 59 (2), 147-151.
  • Headley SA, Amude AM, Alfieri AF, Bracarense APF, Alfieri AA, Summers BA, 2009: Molecular detection of canine distemper virus and the immunohistochemical characterization of the neurologic lesions in naturally occurring old dog encephalitis. J Vet Diagn Invest, 21 (5), 588-597.
  • Koutinas AF, Polizopoulou ZS, Baumgaertner W, Lekkas S, Kontos V, 2002: Relation of clinical signs to pathological changes in 19 cases of canine distemper encephalomyelitis. J Comp Pathol, 126 (1), 47-56.
  • Lan NT, Yamaguchı R, Inomata A, Furuya Y, Uchıda K, Sugano S, Tateyama S, 2006: Comparative analyses of canine distemper viral isolates from clinical cases of canine distemper in vaccinated dogs. Vet Microbiol, 115 (13), 32-45.
  • Masson S, Guitaut N, Medam T, Béata C, 2021: Link between Foreign Body Ingestion and Behavioural Disorder in Dogs. J Vet Behav, 45, 25-32.
  • Mazzola M, Pugliese NR, Zavagli M, De Biase N, Bandini G, Barbarisi G, D'Angelo G, Sollazzo M, Piazzai C, David S, Masi S, Moggi-Pignone A, Gargani L, 2021: Diagnostic and Prognostic Value of Lung Ultrasound B-Lines in Acute Heart Failure With Concomitant Pneumonia. Front Cardiovasc Med, 8, 693912.
  • Plattet P, Rivals JP, Zuber B, Brunner JM, Zurbriggen A, Wittek R, 2005: The fusion protein of wild-type canine distemper virus is a major determinant of persistent infection. Virol, 337 (2), 312–326.
  • Rendon-Marin S, da Fontoura Budaszewski R, Canal CW, Ruiz-Saenz J, 2019: Tropism and molecular pathogenesis of canine distemper virus. Virol J, 16 (30) 1-15.
  • Shell LG, 1990: Canine distemper. Compend Contin Educ Vet, 12 (2), 173-179. Tipold A, Vandevelde M, Jaggy A, 1992: Neurological manifestation of canine distemper virüs infection. J Small Anim Pract, 338 (10): 466-470.
  • Vandevelde M, Zurbriggen A, 2005: Demyelination in canine distemper virus infection: a review. Acta Neuropathol, 109, 56–68.
  • Vite C, 2005: Inflammatory diseases of the central nervous system. In: Braund’s Clinical Neurology in Small Animals: Localization, Diagnosis and Treatment. K. Braund (Ed). International Veterinary Information Service, Ithaca, NY, USA.
  • Willi B, Spiri AM, Meli ML, Grimm F, Beatrice L, Riond B, Bley T, Jordi R, Dennler M, Hofmann-Lehmann R, 2015: Clinical and molecular investigation of a canine distemper outbreak and vector-borne infections in a group of rescue dogs imported from Hungary to Switzerland. BMC Vet Res, 11, 154.
  • Winters KA, Mathes LE, Krakowka S, Olsen RG, 1984: Immunoglobulin class response to canine distemper virus in gnotobiotic dogs. Vet Immunol Immunopathol, 5 (2), 209–215.

Initial Clinical Manifestations of Dogs with Neurological Distemper

Year 2023, , 152 - 159, 22.12.2023
https://doi.org/10.31196/huvfd.1310888

Abstract

The canine distemper virus (CDV) causes demyelination within the central nervous system, gastrointestinal and/or respiratory signs. Due to the wide variety of clinical manifestations, determining the initial clinical manifestation of dogs with neurological CDV of different ages can be used to increase the index of suspicion of CDV, especially in triage. 44 dogs, aged 2-8 months, with clinical findings suggesting the presence of neurological CDV were used, and 38 were enrolled. The dogs were divided into 2 subgroups based on their age. Accordingly, dogs aged 2-4 months were included in Group 1 (n:16), and dogs aged 5-8 months were included in Group 2 (n:22). The body temperature of Group 1 was higher than that of Group 2 (p<0.000). Within the scope of extraneural findings, fever, anorexia, depression, ocular discharge, nasal discharge, diarrhea, uveitis, and pneumonia were detected. Neural findings included behavioral change, head tilt, quadriplegia, convulsion, ataxia and myoclonus. Thoracic radiography revealed a cranioventral alveolar pulmonary pattern and diffuse interstitial pneumonia. The presence of the foreign body in the gastrointestinal tract was prominent in Group 2. On thoracic ultrasonography, B lines (>3 lines) were prominent in both groups. Abdominal ultrasonography revealed dilated intestine segments. It was concluded that the evaluation of the initial clinical manifestation in combination with non-invasive imaging methods might be used to increase the index of suspicion of neurologic CDV before proceeding to laboratory analyses, especially in triage.

Project Number

Bulunmamaktadır.

References

  • Amude AM, Alfieri AA, Alfieri AF, 2006: The nervous form of canine distemper. Vet e Zootec, 13 (2), 125-136.
  • Amude AM, Alfieri AA, Arias MVB, Alfieri AF, 2012: Clinical syndromes of nervous distemper in dogs initially presented without conventional evidences of CDV infection. Semin Ciênc Agrár, 33 (6), 2347-2358.
  • Amude AM, Alfieri AA, Alfieri AF, 2006: Antemortem diagnosis of CDV infection by RT-PCR in distemper dogs with neurological deficits without the typical clinical presentation. Vet Res Commun, 30 (6), 679.
  • Appel MJ, Mendelson SG, Hall WW, 1984: Macrophage Fc receptors control infectivity and neutralization of canine distemper virus-antibody complexes. J Virol, 51 (3), 643–649.
  • Appel MJ, Shek WR, Summers BA, 1982: Lymphocyte-mediated immune cytotoxicity in dogs infected with virulent canine distemper virus. Infect Immun, 37 (2), 592–600.
  • Appel MJ, Yates RA, Foley GL, Bernstein JJ, Santinelli S, Spelman LH, Miller LD, Arp LH, Anderson M, Barr M, Pearce-Kelling S, Summers BA, 1994: Canine distemper epizootic in lions, tigers, and leopards in North America. J Vet Diagn, 6 (3), 277-288.
  • Braund, 1994 Braund KG, Toivio-Kinnucan M, Vallat JM, Mehta JR, Levesque DC, 1994: Distal sensorimotor polyneuropathy in mature Rottweiler dogs. Vet Pathol, 31 (3), 316-326.
  • Braund KG, 1994: Distemper. In: Clinical Syndromes in Veterinary Neurology. Braund KG (Ed), 115-119, St Louis, Mosby.
  • DeLahunta A, Glass E, 2009: Upper motor neuron. In: Veterinary Neuroanatomy and Clinical Neurology, DeLa-hunta A, Glass E (Eds). 192-229, Elsevier Health Science, St Louis, MO, USA.
  • Dewey CWA, 2008: Pratical Guide To Canine and Feline Neurology. 2nd ed. Wiley-Blackwell, Ames, Iowa, USA.
  • Green EC, Appel MJ, 1990: Canine distemper virus. In: Infections diseases of the dog and cat. Greene CE (Ed), 226-241. WB Saunders Company, Philadelphia, USA.
  • Griot C, Burge T, Vandevelde M, Peterhans E, 1989: Antibody-induced generation of reactive oxygen radicals by brain macrophages in canine distemper encephalitis: a mechanism for bystander demyelination. Acta Neuropathol, 78, 396–403.
  • Gülersoy E, Balıkçı C, Günal İ, Şahan A, 2022: Evaluation of the Efficacy of Blood Gases and Hemogram Parameters in the Diagnosis of non Neurogenic Distemper and Parvoviral Enteritis in Dogs with Acute Gastroenteritis. Rev Cient Fac Cienc Vet, 32.
  • Handl S, Wehr U, Zentek J, Krammer-Lukas S, 2009: Histological and immunohistochemical evaluation of duodenal and colonic biopsies after oral bovine lactoferrin supplementation in beagle puppies. J Anim Physiol Anim Nutr, 93, 76–82. doi: 10.1111/j.1439-0396.2007.00781.x
  • Harjes L, Le Pommellet H, Hostnik E, Rudinsky A, 2018: Resolution of esophageal dysmotility following treatment of nasal disease in a dog. Can Vet J, 59 (2), 147-151.
  • Headley SA, Amude AM, Alfieri AF, Bracarense APF, Alfieri AA, Summers BA, 2009: Molecular detection of canine distemper virus and the immunohistochemical characterization of the neurologic lesions in naturally occurring old dog encephalitis. J Vet Diagn Invest, 21 (5), 588-597.
  • Koutinas AF, Polizopoulou ZS, Baumgaertner W, Lekkas S, Kontos V, 2002: Relation of clinical signs to pathological changes in 19 cases of canine distemper encephalomyelitis. J Comp Pathol, 126 (1), 47-56.
  • Lan NT, Yamaguchı R, Inomata A, Furuya Y, Uchıda K, Sugano S, Tateyama S, 2006: Comparative analyses of canine distemper viral isolates from clinical cases of canine distemper in vaccinated dogs. Vet Microbiol, 115 (13), 32-45.
  • Masson S, Guitaut N, Medam T, Béata C, 2021: Link between Foreign Body Ingestion and Behavioural Disorder in Dogs. J Vet Behav, 45, 25-32.
  • Mazzola M, Pugliese NR, Zavagli M, De Biase N, Bandini G, Barbarisi G, D'Angelo G, Sollazzo M, Piazzai C, David S, Masi S, Moggi-Pignone A, Gargani L, 2021: Diagnostic and Prognostic Value of Lung Ultrasound B-Lines in Acute Heart Failure With Concomitant Pneumonia. Front Cardiovasc Med, 8, 693912.
  • Plattet P, Rivals JP, Zuber B, Brunner JM, Zurbriggen A, Wittek R, 2005: The fusion protein of wild-type canine distemper virus is a major determinant of persistent infection. Virol, 337 (2), 312–326.
  • Rendon-Marin S, da Fontoura Budaszewski R, Canal CW, Ruiz-Saenz J, 2019: Tropism and molecular pathogenesis of canine distemper virus. Virol J, 16 (30) 1-15.
  • Shell LG, 1990: Canine distemper. Compend Contin Educ Vet, 12 (2), 173-179. Tipold A, Vandevelde M, Jaggy A, 1992: Neurological manifestation of canine distemper virüs infection. J Small Anim Pract, 338 (10): 466-470.
  • Vandevelde M, Zurbriggen A, 2005: Demyelination in canine distemper virus infection: a review. Acta Neuropathol, 109, 56–68.
  • Vite C, 2005: Inflammatory diseases of the central nervous system. In: Braund’s Clinical Neurology in Small Animals: Localization, Diagnosis and Treatment. K. Braund (Ed). International Veterinary Information Service, Ithaca, NY, USA.
  • Willi B, Spiri AM, Meli ML, Grimm F, Beatrice L, Riond B, Bley T, Jordi R, Dennler M, Hofmann-Lehmann R, 2015: Clinical and molecular investigation of a canine distemper outbreak and vector-borne infections in a group of rescue dogs imported from Hungary to Switzerland. BMC Vet Res, 11, 154.
  • Winters KA, Mathes LE, Krakowka S, Olsen RG, 1984: Immunoglobulin class response to canine distemper virus in gnotobiotic dogs. Vet Immunol Immunopathol, 5 (2), 209–215.
There are 27 citations in total.

Details

Primary Language English
Subjects Veterinary Medicine
Journal Section Research
Authors

Erdem Gülersoy 0000-0001-8511-0150

Canberk Balıkçı 0000-0001-7473-5163

İsmail Günal 0000-0003-3679-4132

Adem Şahan 0000-0002-4779-0893

Kerem Yener 0000-0002-6947-0356

Esma Kısmet 0000-0002-2906-074X

Meral Çıkma This is me 0000-0002-3859-433X

Project Number Bulunmamaktadır.
Early Pub Date December 4, 2023
Publication Date December 22, 2023
Submission Date June 7, 2023
Acceptance Date October 13, 2023
Published in Issue Year 2023

Cite

APA Gülersoy, E., Balıkçı, C., Günal, İ., Şahan, A., et al. (2023). Initial Clinical Manifestations of Dogs with Neurological Distemper. Harran Üniversitesi Veteriner Fakültesi Dergisi, 12(2), 152-159. https://doi.org/10.31196/huvfd.1310888
AMA Gülersoy E, Balıkçı C, Günal İ, Şahan A, Yener K, Kısmet E, Çıkma M. Initial Clinical Manifestations of Dogs with Neurological Distemper. Harran Univ Vet Fak Derg. December 2023;12(2):152-159. doi:10.31196/huvfd.1310888
Chicago Gülersoy, Erdem, Canberk Balıkçı, İsmail Günal, Adem Şahan, Kerem Yener, Esma Kısmet, and Meral Çıkma. “Initial Clinical Manifestations of Dogs With Neurological Distemper”. Harran Üniversitesi Veteriner Fakültesi Dergisi 12, no. 2 (December 2023): 152-59. https://doi.org/10.31196/huvfd.1310888.
EndNote Gülersoy E, Balıkçı C, Günal İ, Şahan A, Yener K, Kısmet E, Çıkma M (December 1, 2023) Initial Clinical Manifestations of Dogs with Neurological Distemper. Harran Üniversitesi Veteriner Fakültesi Dergisi 12 2 152–159.
IEEE E. Gülersoy, C. Balıkçı, İ. Günal, A. Şahan, K. Yener, E. Kısmet, and M. Çıkma, “Initial Clinical Manifestations of Dogs with Neurological Distemper”, Harran Univ Vet Fak Derg, vol. 12, no. 2, pp. 152–159, 2023, doi: 10.31196/huvfd.1310888.
ISNAD Gülersoy, Erdem et al. “Initial Clinical Manifestations of Dogs With Neurological Distemper”. Harran Üniversitesi Veteriner Fakültesi Dergisi 12/2 (December 2023), 152-159. https://doi.org/10.31196/huvfd.1310888.
JAMA Gülersoy E, Balıkçı C, Günal İ, Şahan A, Yener K, Kısmet E, Çıkma M. Initial Clinical Manifestations of Dogs with Neurological Distemper. Harran Univ Vet Fak Derg. 2023;12:152–159.
MLA Gülersoy, Erdem et al. “Initial Clinical Manifestations of Dogs With Neurological Distemper”. Harran Üniversitesi Veteriner Fakültesi Dergisi, vol. 12, no. 2, 2023, pp. 152-9, doi:10.31196/huvfd.1310888.
Vancouver Gülersoy E, Balıkçı C, Günal İ, Şahan A, Yener K, Kısmet E, Çıkma M. Initial Clinical Manifestations of Dogs with Neurological Distemper. Harran Univ Vet Fak Derg. 2023;12(2):152-9.