Köpek seminomlarının histolojik tiplendirilmesi ve morfolojik karakterizasyonu

Abstract

Çalışmanın amacını, seminomları hücre morfolojisi ve histolojik yapılarına göre değerlendirerek alt tiplerine ayırmak oluşturdu. Otuz adet seminom hematoksilen-eozin (HE) ve Periyodik Asit Schiff (PAS) ile boyandı. PAS pozitif vakalar Klasik seminom (CS) (n:5), PAS negatif vakalar ise Spermatositik seminom (SS) (n:23) olarak sınıflandırıldı. Hem pozitif hem de negatif boyanma gösteren vakalar Spermatositik/Klasik seminom (n:2) olarak değerlendirildi. Klasik seminom vakalarında Carcinoma in situ gözlendi (n:3). Her bir vakaya ait hücre morfolojisi ve mitotik indeksleri ayrıntılı olarak verildi. Köpek seminomları üç alt tipe ayrıldı: intratübüler (n:12), diffüz (n:1) ve intratübüler/diffüz (n:10). Sonuç olarak, SS ve CS tiplerinin bir arada görülebileceği düşünüldü ve intratübülerden diffüz forma dönüşümüyle karakterize edilen üçüncü bir tipin intratübüler/diffüz alt türü olduğu gözlendi.

Keywords

• Köpek seminomları
• histopatoloji
• klasik seminom
• spermatositik seminom

Histological Typing and Morphological Characterization of Canine Seminomas

Abstract

The aim of this study was to evaluate seminomas based on cell morphology and histological structures and classify them into subtypes. Thirty canine seminomas were stained with hematoxylin-eosin (HE) and Periodic Acid Schiff (PAS). PAS-positive cases were classified as Classical seminoma (CS) (n:5), while PAS-negative cases were categorized as Spermatocytic seminoma (SS) (n:23). Cases exhibiting both positive and negative staining were evaluated as Spermatocytic/Classical seminoma (n:2). Carcinoma in situ were observed in the cases with Classical seminoma (n:3). The cell morphology and mitotic indices of each case were given in detail. Canine seminomas were classified into three subtypes: intratubular (n:12), diffuse (n:1), and intratubular/diffuse (n:10). As a result, it was thought that SS and CS types could be observed together, and it was observed that the intratubular/diffuse subtype is a third type characterized by its transformation from intratubular to diffuse form.

Keywords

• Canine seminoma
• histopathology
• classical seminoma
• spermatocytic seminoma

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