Viral Enfeksiyonlarda Telomeraz Aktivitesi

Year 2017, , 108 - 111, 30.06.2017

Elif Bayram Metin Çenesiz Semra Okur Gümüşova

https://doi.org/10.31196/huvfd.325795

Abstract

Lineer kromozomların uçlarında yer
alan telomer adı verilen yapılar kromozomların bütünlüğünü sağlar. Kısa
telomerler, DNA hasarında oluşan sinyale benzer bir sinyal üreterek, gerek
yaşlanmayı gerekse de programlı hücre ölümünü tetikler. Telomeraz enzimi de kısalan
telomerleri onararak telomer zincirlerinin uzun kalmasını sağlar. Böylece
hücrelerin bölünme kapasitesinde artış sağlanmış olur. İnsan ve hayvan
onkojenik viruslarının, geliştirdikleri mekanizmalarla telomeraz enzimini
yeniden aktive edebildikleri ispatlanmıştır.  Bu derleme viral enfeksiyonlar ile telomeraz
aktivitesi arasındaki ilişkinin incelendiği bir dizi çalışmadan hazırlanmıştır.

Keywords

Viral enfeksiyonlar, Telomer, Telomeraz

Telomerase Activity in Viral Infections

Abstract

The structures at the ends of
linear chromosomes called telomeres provide the integrity of the chromosomes.
Short telomeres produce a signal similar to DNA damage and triggering both
programmed cell aging and programmed cell death. Also, telomerase enzyme
restores shortened telomeres and allowing telomerase chains to stay longer.
Thus increases the cleavage capacity of the cells. It has been proven that
human and animal oncogenic viruses can re-activate telomerase enzyme in the
cell through their new developed mechanisms. This review is prepared with
series of studies that is examined the relationship between viral infections
and telomerase activity.

Keywords

Viral infections, Telomer, Telomerase

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