Tavşanlarda Sistemik Olarak Kullanılan Midazolam, Ketamin ve İsofluranın Gözyaşı Üretimi ve Göziçi Basıncı Üzerine Olan Etkilerinin Deneysel Olarak Araştırılması

Year 2018, , 21 - 25, 04.07.2018

Muharrem Erol , Hanifi Erol Gültekin Atalan Zafer Doğan Muhammed Kaan Yönez Şule Melek

https://doi.org/10.31196/huvfd.458783

Cited By: 2

Abstract

Bu çalışmanın amacı;
tavşanlarda midazolam, ketamin ve isofluran anestezik ajanların gözyaşı üretimi
ve göziçi basıncı üzerine olan etkilerini belirlemektir. Bu çalışmada yirmi
adet (n = 20) sağlıklı, (ortalama ağırlıkları 2.20 ± 0.50 kg, yaşları 16 hafta)
erkek Yeni Zelanda tavşanı kullanıldı. Birinci grupta intramuskuler (İM)
midazolam 3mg/kg, ve ketamine İM 30 mg/ kg uygulanarak anestezi sağlandı.
Ikinci grupta (Grup 2), midazolam ve ketamine enjeksiyonundan sonra genel
anestezi için %2’lik İsofluran uygulandı. Anesteziden sonra her iki grupta da intraoküler basınç değerlerinde düşüşler görüldü. Birinci
grupta (Grup I) göz içi basıncı sağ gözde 10.3 ± 0.85 mmHg ölçülürken, sol
gözde 11.4 ± 0.95 mmHg olarak ölçüldü. İkinci grupta (Grup II) göziçi basıncı
sağ gözde 8.5 ± 0.85 mmHg ölçülürken, sol gözde 8.3 ± 0.85 mmHg (sol göz)
vardı. Bu çalışmanın sonucunda tavşanlarda sistemik olarak kullanılan
midazolam, ketamin ve isofluran gibi anestezik ajanların GİB ve gözyaşı salgısını
azalttığı görüldü.

Keywords

Anestezi, Göz içi basıncı, Tavşan, Gözyaşı üretimi

Effects of Systemically Used Midazolam, Ketamine and Isoflurane Anesthetic Agents on Intraocular Pressure and Tear Production in Rabbits

Abstract

The aim of this
study was to determine of the effects of midazolam, ketamine and isoflurane
anesthetic agents on tear production and intraocular pressure in rabbits. In
this study twenty healthy (n=20) male white New Zealand rabbits (mean weight
2.20 ± 0.50 kg, age 16 weeks) were used. Anesthesia was performed intramuscular
(IM) midazolam 3 mg/kg, and ketamine 30 mg/kg in group I. In second group (Group
II), after midazolam and ketamine injections isoflurane 2% was used for general
anesthesia. After anesthesia means intraocular pressure (IOP) decreased in both
groups. Intraocular pressure in first group (Group I) was 10.3 ± 0.85 mmHg
(right eyes), 11.4 ± 0.95 mmHg (left eyes) while it was 8.5 ± 0.85 mmHg (right
eyes), 8.3 ± 0.85 mmHg (left eyes) n group II. The result of this study show
that systemically used midazolam, ketamine and isoflurane anesthetic agents
decrease IOP and tear secretion in rabbits.

Keywords

Anesthesia, Intraocular pressure, Rabbit, Tear production

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