Tavşanlarda Sistemik Olarak Kullanılan Midazolam, Ketamin ve İsofluranın Gözyaşı Üretimi ve Göziçi Basıncı Üzerine Olan Etkilerinin Deneysel Olarak Araştırılması

Abstract

Bu çalışmanın amacı; tavşanlarda midazolam, ketamin ve isofluran anestezik ajanların gözyaşı üretimi ve göziçi basıncı üzerine olan etkilerini belirlemektir. Bu çalışmada yirmi adet (n = 20) sağlıklı, (ortalama ağırlıkları 2.20 ± 0.50 kg, yaşları 16 hafta) erkek Yeni Zelanda tavşanı kullanıldı. Birinci grupta intramuskuler (İM) midazolam 3mg/kg, ve ketamine İM 30 mg/ kg uygulanarak anestezi sağlandı. Ikinci grupta (Grup 2), midazolam ve ketamine enjeksiyonundan sonra genel anestezi için %2’lik İsofluran uygulandı. Anesteziden sonra her iki grupta da intraoküler basınç değerlerinde düşüşler görüldü. Birinci grupta (Grup I) göz içi basıncı sağ gözde 10.3 ± 0.85 mmHg ölçülürken, sol gözde 11.4 ± 0.95 mmHg olarak ölçüldü. İkinci grupta (Grup II) göziçi basıncı sağ gözde 8.5 ± 0.85 mmHg ölçülürken, sol gözde 8.3 ± 0.85 mmHg (sol göz) vardı. Bu çalışmanın sonucunda tavşanlarda sistemik olarak kullanılan midazolam, ketamin ve isofluran gibi anestezik ajanların GİB ve gözyaşı salgısını azalttığı görüldü.

Keywords

• Anestezi,Göz içi basıncı,Tavşan,Gözyaşı üretimi

Effects of Systemically Used Midazolam, Ketamine and Isoflurane Anesthetic Agents on Intraocular Pressure and Tear Production in Rabbits

Abstract

The aim of this study was to determine of the effects of midazolam, ketamine and isoflurane anesthetic agents on tear production and intraocular pressure in rabbits. In this study twenty healthy (n=20) male white New Zealand rabbits (mean weight 2.20 ± 0.50 kg, age 16 weeks) were used. Anesthesia was performed intramuscular (IM) midazolam 3 mg/kg, and ketamine 30 mg/kg in group I. In second group (Group II), after midazolam and ketamine injections isoflurane 2% was used for general anesthesia. After anesthesia means intraocular pressure (IOP) decreased in both groups. Intraocular pressure in first group (Group I) was 10.3 ± 0.85 mmHg (right eyes), 11.4 ± 0.95 mmHg (left eyes) while it was 8.5 ± 0.85 mmHg (right eyes), 8.3 ± 0.85 mmHg (left eyes) n group II. The result of this study show that systemically used midazolam, ketamine and isoflurane anesthetic agents decrease IOP and tear secretion in rabbits.

Keywords

• Anesthesia,Intraocular pressure,Rabbit,Tear production

References

1. Alkan F, Izci C, Tepeli C, Koc Y, 2004: Evaluation of the Schirmer tear test in clinically normal Turkish hunting dogs. Vlaams Dier. ge nees kun dig. Tijd schrift, 73, 263-279.
2. Dogan E, Yanmaz LE, Senocak MG, Okumus Z, 2016: Comparasion of propofol, ketamine and ketofol on intraocular pressure in New Zealand white rabbits. Revue Med Vet, 167, 18-21.
3. Ghaffari MS, Moghaddassi AP, 2010: Effects of Ketamin-diazepam and ketamin-acepromazine combinations on intraocular pressure in rabbits. Veterinary Anaesthesia Analgesia, 37, 269–272.
4. Gianetto C, Piccione G, Giudice E, 2009: Daytime profile of the intraocular pressure and tear production in normal dog. Vet Ophthal,12, 302-305.
5. Grundon RA, Anderson GA, Lynch M, Hardman C, O’Reilly A, Stanley RG, 2011: Schirmer tear tests and intraocular pressures in conscious and anesthetized koalas (Phascolarctus cinereus). Vet Ophthal, 14, 292-295.
6. Hazra S, Pauli H, Biswas B, Konar A, 2011: Anesthesia for Intraocular Surgery in Rabbits. Scand J Lab Anim Sci, 38, 81-87.
7. Holve D, Gum GG, Pritt SL, 2013: Effect of sedation with xylazine and ketamine on intraocular pressure in New Zealand White Rabbits. J Am Assoc Lab Anim Sci, 52, 488-490.
8. Kovaljuca L and Birgele E, 2011: The effects of some medication and general anesthesia drugs on intraocular pressure and pupil diameter in dog’s eyes. LLU Raksti,26, 77-83.

9. Meekins JM, Overton TL, Rankin AJ, Roush JK, 2016: Effect of oral administration of carprofen on intraocular pressure in normal dogs. J Vet Pharmacol Therap, 39, 344-349.
10. Miller PE, 2008: The glaucomas, Maggs DJ, Miller PE, Ofri R (4th. eds): In Slatter’s Fundamentals of Veterinary Ophthalmology. pp. 230-257. Saunders, St. Louis.
11. Ollivier FJ, Plummer CE, Barrie KP (2008). Ophthalmic examination and diagnostics, Section 1: the eye examination and diagnostic procedures. In: Essentials of 86 Veterinary Ophthalmology. 2 nd ed., Gelatt KN, (edt), Blackwell publishing, USA: 3-22
12. Ofri R, Horowitzs IH, Levison M, Kass PH, 2001: Intraocular pressure and tear production in captive eland and fallow deer. J Wildl Dis,37, 387-390.
13. Ofri R, Steinmetz A, Thielebein J, Horowitz IH, Oechtering G, Kass PH, 2008: Factors affecting intraocular pressure in lions. The Vet J ,177, 124-129.
14. Pereira FQ, Bercht BS, Soeres MG, Mota MGB, Pigatto JAT, 2011: Comparison of a rebound and an applanation tonometer for measuring intraocular pressure in normal rabbits. Veterinary Opthalmology, 14, 321-326.
15. Pintor J, Martin L, Pelaez T, Hoyle CHV, Peral A, 2001: Involvement of melatonin MT3 receptors in the regulation of intraocular pressure in rabbits. Eur J Pharmaco, 146, 251-254.
16. Reitsamer HA, Kiel JW, Harrison JM, Ransom NL, Mckinnon SJ, 2004: Tonopen measurement of intraocular pressure in mice. Exp Eye Res, 78, 799-804.
17. Riberio AP, Piso DYT, Pauda IRM, Silva ML, Laus JL, 2010: Intraocular pressure and tear secretion in Saanen goats with different ages. Pesq Vet Bras, 30, 798-802.
18. Santangelo B, Micieli F, Marino F et al, 2015: Plasma concentrations and sedative effects of a dexmedetomidine, midazolam, and butorphanol combination after transnasal administration in healthy rabbits. J Vet Pharmacol Therap, 39, 408-411.
19. Sarıcaoğlu MS, 2010. Yeni tonometreler ve göz içi basıncı ölçümünde yeni tartışma: korneanın biyomekanik özellikleri. Glo-Kat; 5: 67-74.
20. Sator S, Wildling E, Schabernig C, Akramain J, Zulus E, Winkler M, 1998: Desflurane maintains intraocular pressure at an equivalent level to isoflurane and propofol during unstressed non-ophthalmic surgery. Br J Anaesth, 80, 243-244.
21. Sator-Katzenschlager S, Deusch E, Dolezal S et al, 2002: Sevoflurane and propofol decrease intraocular pressure equally during non-ophthalmic surgery and recovery. Br J Anaesth, 89, 764-766.
22. Schäfer R, Klett J, Auffarht G. et al, 2002: Intraocular pressure more reduced during anaesthesia with propofol than with sevoflurane: both comined with remifentanil. Acta Anaesthesiol Scand, 46, 703-706.
23. Swinger RL, Langan JN, Hamor R, 2009: Ocular bacterial flora, tear production, and intraocular pressure in a captive flock of humboldt penguins (Spheniscus humboldti). J Zoo Wildl Med, 40, 430-436