Research Article
Hipertrofik Kardiyomyopatili Kedilerde Trombosit ve Ortalama Trombosit Hacmi Düzeyleri Erken Emboli Oluşumunu Belirlemede Kullanılabilir mi?
Abstract
Hipertrofik
kardiyomyopati (HCM) kedilerin sıklıkla rapor edilen kalp hastalığıdır.
Arterial thromboembolizm (ATE) ise thrombüs fragmentlerinin arteriyal dolaşıma
girerek damarlarda obstrüksiyon yaratması sonucu ilişkili klinik belirtilerin
ortaya çıkması olarak tanımlanmaktadır. Bu çalışmada; ATE’in eşlik ettiği
HCM’li kedilerde, ATE’in bulunmadığı HCM’li kedilerle karşılaştırıldığında
artmış koagülasyon aktivitesi (düşük trombosit, yüksek MPV düzeyleri) ile
ilgili hipotez değerlendirilmiştir. Çalışma çeşitli yaş ve ırklardaki 25 kedi
ile gerçekleştirildi. HCM teşhisinde; sağ parasternal kısa eksende sol
ventriküler konsantrik hipertrofi ve sol ventriküler duvar kalınlığı (LVWd ≥6 mm) kriterleri baz alındı. Sağ kısa eksende
artmış sol atrium/aort oranı (LA/Ao > 2 mm) belirlendi. Diğer
Ekokardiyografik değerlendirmeler için sağ parasternal uzun eksen (sağ PLAX) ve
M mod kullanıldı. Çalışmada hastalar (n:25); grup 1 (HCM+ATE; n:9) ve grup 2
(HCM; n: 16) olarak sınıflandırıldı. Grup 1’de trombosit (PLT) ortalamaları
grup 2 ile karşılaştırıldığında daha düşük olmasına rağmen gruplar arasında
istatistiki farklılığa rastlanmadı (p < 0,05). Ortalama trombosit hacmi (MPV)
ortalamaları ise Grup 1’de grup 2’ye göre daha yüksek olmasına rağmen gruplar
arasında istatistiki olarak fark saptanmadı. Sonuç olarak; her ne kadar ATE’nin
eşlik ettiği HCM’li kedilerde artmış hiperkoagülatif durumun göstergesi olan
daha düşük PLT ve daha yüksek MPV düzeyleri bulunduysa da, bu parametrelerin
erken thrombüs oluşumunu ortaya koymadaki kullanılabilirliğini belirlemek için
daha geniş olgu sayılı prospektif çalışmalara ihtiyaç duyulmaktadır.
References
- Bedard C, Lanevschi‐Pietersma A, Dunn M, 2007: Evaluation of coagulation markers in the plasma of healthy cats and cats with asymptomatic hypertrophic cardiomyopathy. Vet Clin Pathol, 36, 167-172.
- Dwyer L, 2015: Thromboembolic disease in dogs and cats. Veterinary Nursing Journal, 30, 118.
- Erne P, Wardle J, Sanders K, Lewis SM, Maseri A, 1988: Mean platelet volume and size distribution and their sensitivity to agonists in patients with coronary artery disease and congestive heart failure. Thromb Haemost, 59, 259-63.
- Fox PR, Liu SK, Maron BJ, 1995: Echocardiographic assessment of spontaneously occurring feline hypertrophic cardiomyopathy. An animal model of human disease. Circulation, 92, 2645-2651.
- Glud T, Schmidt EB, Kristensen SD, Arnfred T, 1986: Platelet number and volume during myocardial infarction in relation to infarct size. Acta Med Scand, 220, 401-5.
- Helenski CA, Ross JN, 1987: Platelet aggregation in feline cardiomyopathy. J Vet Internal Med, 1, 24-28.
- Hogan DF, 2017: Feline Cardiogenic Arterial Thromboembolism. Vet Clin Small Anim, 47, 1065-1082.
- Kang ME, Min SH, Kim SG, Lee CM, Park HM, 2015: Characteristic Clinical Features and Survival in Cats with Symptomatic Hypertrophic Cardiomyopathy. J Biomed Res, 16, 152-158.
- Laste NJ, Harpster NK, 1995: A retrospective study of 100 cases of feline distal aortic thromboembolism: 1977–1993. J Am Anim Hosp Assoc, 31, 492-500.
- Liu SK, Fox PR, 1999: Cardiovascular pathology. In “Textbook of Canine and Feline Cardiology: Principles and Practice”, Ed; Fox PR, Sisson D, Moise NS, W.B. Saunders, Philadelphia, USA.
- Martin JF, Bath PMW, 1991: Platelets and megakaryocytes in vascular disease. In “Antitrombotics: pathophysiological rationale for pharmacological inventions”, Ed; Herman AG, Kluwer Academic Publishers, Boston.
- Martin JF, Plumb J, Kilby RS, Kishk YT, 1983: Changes in volume and density of platelets in myocardial infarction. Br Med J, 287, 456-9.
- Park Y, Schoene N, Harris W, 2002: Mean platelet volume as an indicator of platelet activation: methodological issues. Platelets, 13, 301-306.
- Payne J, Luis Fuentes V, Boswood A, Connolly D, Koffas H, Brodbelt D, 2010: Population characteristics and survival in 127 referred cats with hypertrophic cardiomyopathy (1997 to 2005). J Small Anim Pract, 51, 540-547.
- Payne JR, Borgeat K, Connolly DJ, Boswood A, Dennis S, Wagner T, Menaut P, Maerz I, Evans D, Simons VE, Brodbelt DC, Luis Fuentes V, 2013: Prognostic indicators in cats with hypertrophic cardiomyopathy. J Vet Intern Med, 27, 1427-1436.
- Pereg D, Berlin T, Mosseri M, 2010: Mean platelet volume on admission correlates with impaired response to thrombolysis in patients with ST-elevation myocardial infarction. Platelets, 21, 117-121.
- Ross R, 1999: Atherosclerosis: an inflammatory disease. N Engl J Med, 340, 115-126.
- Rush JE., Freeman LM., Fenollosa NK., Brown DJ., 2002. Population and survival characteristics of cats with hypertrophic cardiomyopathy: 260 cases (1990–1999). J Am Vet Med Assoc, 220, 202–207.
- Schober KE, Fuentes VL, Bonagura JD, 2003: Comparison between invasive hemodynamic measurements and noninvasibe assessment of left ventricular diastolic function by use of doppler echocardiography in healthy anesthetized cats. Am J Vet Res, 64, 93-103.
- Sewell R, Ibbotson RM, Philips R, Cardson P, 1984: High mean platelet volume after myocardial infarction: is it due consumption of small platelet? Br Med J, 289, 1576- 8.
- Smith NM, Pathansali R, Bath PM, 1999: Platelets and stroke. Vasc Med, 4, 165-172.
- Smith SA, Tobias AH, 2004: Feline arterial thromboembolism: An update. Vet Clin North Am Small Anim Pract, 34, 1245-1271.
- Smith SA, Tobias AH, Jacob KA, Fine DM, Grumbles PL, 2003: Arterial thromboembolism in cats: acute crisis in 127 cases (1992e2001) and long-term management with low-dose aspirin in 24 cases. J Vet Int Med, 17, 73-83.
- Spalla I, Locatelli C, Riscazzi G, Santagostino S, Cremaschi E, Brambilla P, 2016: Survival in cats with primary and secondary cardiomyopathies. Journal of Feline Medicine and Surgery, 18, 501–509.
- Stokol T, Brooks M, Rush JE, Rishniw M, Erb H, Rozanski E, Kraus MS, Gelzer AR, 2008: Hypercoagulability in cats with cardiomyopathy. J Vet Intern Med, 22, 546-552.
- Welles EG, Boudreau MK, Crager CS, Tyler JW, 1994: Platelet function and anti-thrombin, plasminogen and fibrinolytic activities in cats with heart disease. Am J Vet Res, 55, 619-627.a
Year 2018,
, 84 - 88, 04.07.2018
Abstract
References
- Bedard C, Lanevschi‐Pietersma A, Dunn M, 2007: Evaluation of coagulation markers in the plasma of healthy cats and cats with asymptomatic hypertrophic cardiomyopathy. Vet Clin Pathol, 36, 167-172.
- Dwyer L, 2015: Thromboembolic disease in dogs and cats. Veterinary Nursing Journal, 30, 118.
- Erne P, Wardle J, Sanders K, Lewis SM, Maseri A, 1988: Mean platelet volume and size distribution and their sensitivity to agonists in patients with coronary artery disease and congestive heart failure. Thromb Haemost, 59, 259-63.
- Fox PR, Liu SK, Maron BJ, 1995: Echocardiographic assessment of spontaneously occurring feline hypertrophic cardiomyopathy. An animal model of human disease. Circulation, 92, 2645-2651.
- Glud T, Schmidt EB, Kristensen SD, Arnfred T, 1986: Platelet number and volume during myocardial infarction in relation to infarct size. Acta Med Scand, 220, 401-5.
- Helenski CA, Ross JN, 1987: Platelet aggregation in feline cardiomyopathy. J Vet Internal Med, 1, 24-28.
- Hogan DF, 2017: Feline Cardiogenic Arterial Thromboembolism. Vet Clin Small Anim, 47, 1065-1082.
- Kang ME, Min SH, Kim SG, Lee CM, Park HM, 2015: Characteristic Clinical Features and Survival in Cats with Symptomatic Hypertrophic Cardiomyopathy. J Biomed Res, 16, 152-158.
- Laste NJ, Harpster NK, 1995: A retrospective study of 100 cases of feline distal aortic thromboembolism: 1977–1993. J Am Anim Hosp Assoc, 31, 492-500.
- Liu SK, Fox PR, 1999: Cardiovascular pathology. In “Textbook of Canine and Feline Cardiology: Principles and Practice”, Ed; Fox PR, Sisson D, Moise NS, W.B. Saunders, Philadelphia, USA.
- Martin JF, Bath PMW, 1991: Platelets and megakaryocytes in vascular disease. In “Antitrombotics: pathophysiological rationale for pharmacological inventions”, Ed; Herman AG, Kluwer Academic Publishers, Boston.
- Martin JF, Plumb J, Kilby RS, Kishk YT, 1983: Changes in volume and density of platelets in myocardial infarction. Br Med J, 287, 456-9.
- Park Y, Schoene N, Harris W, 2002: Mean platelet volume as an indicator of platelet activation: methodological issues. Platelets, 13, 301-306.
- Payne J, Luis Fuentes V, Boswood A, Connolly D, Koffas H, Brodbelt D, 2010: Population characteristics and survival in 127 referred cats with hypertrophic cardiomyopathy (1997 to 2005). J Small Anim Pract, 51, 540-547.
- Payne JR, Borgeat K, Connolly DJ, Boswood A, Dennis S, Wagner T, Menaut P, Maerz I, Evans D, Simons VE, Brodbelt DC, Luis Fuentes V, 2013: Prognostic indicators in cats with hypertrophic cardiomyopathy. J Vet Intern Med, 27, 1427-1436.
- Pereg D, Berlin T, Mosseri M, 2010: Mean platelet volume on admission correlates with impaired response to thrombolysis in patients with ST-elevation myocardial infarction. Platelets, 21, 117-121.
- Ross R, 1999: Atherosclerosis: an inflammatory disease. N Engl J Med, 340, 115-126.
- Rush JE., Freeman LM., Fenollosa NK., Brown DJ., 2002. Population and survival characteristics of cats with hypertrophic cardiomyopathy: 260 cases (1990–1999). J Am Vet Med Assoc, 220, 202–207.
- Schober KE, Fuentes VL, Bonagura JD, 2003: Comparison between invasive hemodynamic measurements and noninvasibe assessment of left ventricular diastolic function by use of doppler echocardiography in healthy anesthetized cats. Am J Vet Res, 64, 93-103.
- Sewell R, Ibbotson RM, Philips R, Cardson P, 1984: High mean platelet volume after myocardial infarction: is it due consumption of small platelet? Br Med J, 289, 1576- 8.
- Smith NM, Pathansali R, Bath PM, 1999: Platelets and stroke. Vasc Med, 4, 165-172.
- Smith SA, Tobias AH, 2004: Feline arterial thromboembolism: An update. Vet Clin North Am Small Anim Pract, 34, 1245-1271.
- Smith SA, Tobias AH, Jacob KA, Fine DM, Grumbles PL, 2003: Arterial thromboembolism in cats: acute crisis in 127 cases (1992e2001) and long-term management with low-dose aspirin in 24 cases. J Vet Int Med, 17, 73-83.
- Spalla I, Locatelli C, Riscazzi G, Santagostino S, Cremaschi E, Brambilla P, 2016: Survival in cats with primary and secondary cardiomyopathies. Journal of Feline Medicine and Surgery, 18, 501–509.
- Stokol T, Brooks M, Rush JE, Rishniw M, Erb H, Rozanski E, Kraus MS, Gelzer AR, 2008: Hypercoagulability in cats with cardiomyopathy. J Vet Intern Med, 22, 546-552.
- Welles EG, Boudreau MK, Crager CS, Tyler JW, 1994: Platelet function and anti-thrombin, plasminogen and fibrinolytic activities in cats with heart disease. Am J Vet Res, 55, 619-627.a
There are 26 citations in total.
Details
| Primary Language | Turkish |
|---|---|
| Journal Section | Research |
| Authors | |
| Publication Date | July 4, 2018 |
| Submission Date | March 5, 2018 |
| Acceptance Date | June 7, 2018 |
| Published in Issue | Year 2018 |
