Effects of oral and topical Momordica charantia-Propolis premix on wound healing

Year 2020, , 53 - 58, 25.06.2020

Elif Doğan , Güler Karademir , Semin Gedikli Sıtkıcan Okur

https://doi.org/10.31196/huvfd.704364

Abstract

Momordica charantia ve Propolis'in (MCP) antibakteriyel, antifungal, antioksidan ve antienflamatuar özelliklere sahip olduğu bildirilmektedir. Bu çalışmada, 60 yetişkin erkek sıçanda MCP'nin oral ve topikal uygulanmasının yara iyileşmesi üzerindeki etkinliğinin belirlenmesi amaçlanmıştır. Çalışmada kontrol sıçanlarındaki yaralar tedavi edilmeden bırakıldı, MCP-oral gruptaki sıçanlar oral MCP ile tedavi edildi ve MCP topikal grubundaki hayvanlar, yara üzerine MCP tozu dökülerek tedavi edildi. Yara boyutu 3., 7., 14. ve 21. günlerde ölçüldü ve her iki gruptaki beş hayvandan doku örnekleri alındı. Doku örnekleri histopatolojik olarak değerlendirildi. Takip süresi boyunca tedaviyi takiben remisyon, her sıçan için orijinal yara boyutunun yüzdesi olarak tanımlandı. Verilerin analizi için iki yönlü bir ANOVA kullanıldı. Ortalama yara yüzey alanı 1.69 cm2 olarak ölçüldü. Deneyin sonunda ortalama azalma MCP-topikal grubunda %81.40 ve MCP-oral grubundaki yaralarda%87.85 idi. Yara boyutundaki en düşük azalma kontrol grubunda (%45.55) ölçüldü. Yara boyutundaki küçülme, deney sonunda MCP grupları arasında önemli ölçüde farklı değildi. 21. güne kadar hem MCP-oral hem de MCP-topikal gruplarda yeniden epitelizasyon ve neovaskülarizasyon tamamlandı. Genel olarak, oral ve topikal MCP ile yapılan tedaviler yara iyileşmesinde eşit derecede etkilidir. Momordica charantia ve Propolis'in hem oral hem de topikal uygulamaları yara iyileşmesinin hızlandırılması için düşünülebilir.

Keywords

momordica charantia, propolis, rat, Yara iyileşmesi

Project Number

2015/048

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