Surgical Management of Abortion in a Rat

Year 2021, , 196 - 198, 12.12.2021

Serdal Kurt , Seçkin Salar

https://doi.org/10.31196/huvfd.827437

Abstract

The gestation period of rats is on average 21 to 23 days. Conceptus can be detected by ultrasonography after the 8‐9th days of the pregnancy. The total number of fetuses per pregnancy is 1 to 20. In some cases, abortion occurs depending on many etiological factors, and it is the most common complication of pregnancy. The subject of the present case report was the surgical management of spontaneous abortion using inhalation anesthesia in a rat. The material of the case report was a female albino 2‐year‐ old rat weighing about 450 gr. The rat was admitted with vaginal bleeding and abortion in to the clinic. In anamnesis, it was reported that a pup was stillborn about three hours ago and then no other pup was delivered. Furthermore, it was informed that there was ongoing vaginal bleeding since the last 4‐5 hours. Upon physical examination and ultrasonography, the case was diagnosed as abortion. It was decided to intervene with the abortion by surgery. The rat was premedicated subcutaneously with atropine sulphate and general anesthesia was induced with isoflurane through inhalation. Then, celiotomy was performed at cauda umbilicus. In total, 13 non viable fetuses were removed from both uterine horns. Incision wounds were sutured and the rat was evenly awakened from anesthesia and discharged. In conclusion, surgical management of the abortion case using inhalation anesthesia was successfully performed on the rat.

Keywords

Abortion, Fetus, Rat, Surgery

Thanks

This article was presented as abstract (online oral presentation) in INESEC 2020-4th International Health sciences Conference (IHSC 2020).

Bir Sıçanda Abortusun Cerrahi Yönetimi

Abstract

Sıçanlarda gebelik süresi ortalama 21 ila 23 gün arasındadır. Konseptus gebeliğin 8‐9. günlerinden sonra ultrasonografi ile tespit edilebilir. Gebelik başına toplam fetüs sayısı 1 ile 20'dir. Bazı durumlarda, birçok nedene bağlı olarak abort meydana gelir ve gebeliğin en sık görülen komplikasyonudur. Bu olgu sunumunun konusu, bir sıçanda spontan abortusun inhalasyon anestezisi ile cerrahi yönetimiydi. Olgu sunumunun materyali, 2 yaşında ve 450 gr ağırlığında dişi bir albino sıçandı. Sıçan vajinal kanama ve abort şikayeti ile kliniğe getirildi. Anamnezde, bir yavrunun yaklaşık üç saat önce ölü doğduğu ve ardından başka yavrunun doğmadığı bildirildi. Ayrıca son 4‐5 saattir devam eden vajinal kanama olduğu bilgisi verildi. Fiziksel ve ultrasonografi muayenesinde olguya abortus tanısı kondu. Cerrahi müdahaleye karar verildi. Sıçana premedikasyon olarak deri altı yolla atropin sülfat uygulandı ve genel anestezi inhalasyon yoluyla izofluran ile indüklendi. Daha sonra göbek deliğinin gerisinden ensizyon yapıldı. Uterusun iki kornusundan toplam 13 ölü fetüs çıkarıldı. Ensizyon hattı dikildi ve sıçan anesteziden sorunsuz şekilde uyandırılarak taburcu edildi. Sonuç olarak, sıçanda abort olgusunun inhalasyon anestezisi ile cerrahi yönetimi başarıyla gerçekleştirildi.

Keywords

Abort, Cerrahi, Fetüs, Sıçan

References

• Barrington JW, Lindsay P, James D, Smith S, Roberts A, 1996: Selenium deficiency and miscarriage: a possible link?. BJOG, 103(2), 130-132.
• Bekyürek T, (2002): Laboratuvar hayvanlarında üreme sorunları, In: Evcil hayvanlarda doğum ve İnfertilite, Alaçam E (ed), 355-382, Medisan Yayınları, Ankara.
• Brunson DB (1997): Pharmacology of inhalation anesthetics, In: Anesthesia and analgesia in laboratory animals, Kohn DF, Wixson SK, White WJ, Benson GJ (ed), 29-40, Elsevier, Acedemic pres, London.
• He Y, Sun Q, 2018: IFN-γ induces upregulation of TNF-α, downregulation of MMP-2 and MMP-9 expressions in abortion rat. Eur Rev Med Pharmacol Sci, 22(15), 4762-4767.
• Kazerooni T, Mousavizadeh K, Abdollahee A, Sarkarian M, Sattar A, 2006: Abortifacient effect of Prangos ferulacia on pregnant rats. Contraception, 73(5), 554-556.
• Narotsky MG, Best DS, Guidici DL, Cooper RL, 2000: Strain comparisons of atrazine-induced pregnancy loss in the rat 1. Reprod toxicol, 15(1), 61-69.
• Ypsilantis P, Deftereos S, Prassopoulos P, Simopoulos C, 2009: Ultrasonographic diagnosis of pregnancy in rats. J Am Assoc Lab Anim Sci, 48(6), 734-739.
• Zhang Y, Yan W, Ge PF, Li Y, Ye Q, (2016): Study on prevention effect of Zishen Yutai pill combined with progesterone for threatened abortion in rats. Asian Pac J Trop Med, 9(6), 577-581.