Tiftik Keçilerinde Doğum Şeklinin Bazı Oksidatif Stres Belirteçleri ve Hormon Konsantrasyonları Üzerine Etkisi

Year 2021, , 60 - 65, 22.06.2021

Serdal Kurt , Nebi Çetin , Funda Eşki

https://doi.org/10.31196/huvfd.881150

Abstract

Güç doğum, spontan doğumun belirli bir zaman içerisinde herhangi bir müdahale olmadan gerçekleşemediği olgu olarak tanımlanmaktadır. Güç doğum steroid hormon seviyesi ile ilişkili olabilmekte ve oksidatif stres üzerine etki edebilmektedir. Bu çalışmanın amacı, normal ve sezaryen ile doğum yapan Tiftik keçilerinde malondialdehid (MDA), süperoksit dismutaz (SOD), glutatyon peroksidaz (GSH-Px), total glutatyonun (GSH) progesteron (P4) ve östradiol (E2) konsantrasyonlarını değerlendirmektir. Yapılan çalışmada, keçiler normal (n=10) ve sezaryen ile doğum (n=10) olmak üzere 2 gruba ayrıldı. Her iki grubun kan örnekleri, doğumdan sonraki ilk yarım saat içinde jugular venadan alındı. MDA, GSH-Px, total GSH seviyelerinde gruplar arasında önemli bir farklılık (P>0.05) görülmedi. Sezaryen grubunda hem SOD (P <0.01), hem de P4 ve E2 konsantrasyonları anlamlı olarak daha yüksekti (P <0.05). Sonuç olarak, sezaryen ile doğum yapan keçilerde SOD, P4 ve E2 seviyelerinde farklılıklar gözlemlendi. P4 ve E2 konsantrasyonlarındaki farklılıkların güç doğumun etiyopatogenezinde rol alabileceği ve güç doğuma bağlı artan strese karşı mücadele için endojen bir antioksidan madde olan SOD’un üretiminin arttığı kanaatine varıldı.

Keywords

Güç doğum, Hormon, Keçi, Oksidatif stres

Thanks

Sunulan çalışma 4. Uluslararası Akdeniz Sempozyumu’nda (22-24 Ekim 2020, Mersin) özet metin olarak sunulmuştur

The Effect of Delivery Mode on Some Oxidative Stress Markers and Hormone Concentrations in Angora Goats

Abstract

Dystocia is defined as the situation in which spontaneous parturition cannot occur at a given time without any intervention. It can be related to steroid hormone levels and can affect oxidative stress. The purpose of this study was to evaluate the concentrations of malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), total glutathione (GSH), progesterone (P4), and estradiol (E2) in goats which were parturated normally and with cesarean section. In the study, goats were divided into two groups as normal delivery (n=10) and cesarean delivery groups (n=10). Blood samples of both groups were taken from the jugular vein within the first half-hour after parturition. There was no statistically (P>0.05) difference between the groups in MDA, GSH-Px, total GSH levels. Differences in both SOD (P<0.01) and levels of P4 and E2 were significantly higher in the cesarean group (P<0.05). In conclusion, differences were observed in SOD, P4, and E2 concentrations in goats delivered by cesarean section. It was concluded that the differences in P4 and E2 concentrations might play a role in the etiopathogenesis of dystocia, and the production of SOD, an endogenous antioxidant substance, has increased to combat the increased stress due to dystocia.

References

• Bansal AK, Singh AK, Cheema RS, Brar PS, Gandotra VK, Singh P, Prabhakar S, 2011: Status of oxidative stress and antioxidant enzymes in normally calved and dystocia affected buffaloes. Indian J Anim Sci, 81 (9), 915.
• Erel O, 2005: A new automated colorimetric method for measuring total oxidant status. Clin Biochem, 38 (12), 1103-1111.
• Erisir M, Akar Y, Gurgoze SY, Yuksel M, 2006: Changes in plasma malondialdehyde concentration and some erythrocyte antioxidant enzymes in cows with prolapsus uteri, caesarean section, and retained placenta. Revue Med Vet, 157 (2), 80-83.
• Eşki F, Kurt S, Demir PA, 2021: Effect of different estrus synchronization protocols on estrus and pregnancy rates, oxidative stress and some biochemical parameters in Hair goats. Small Rumin Res, 106348.
• Ghoneim IM, Waheed MM, Al-Eknah MM 2016: Effect of dystocia on some hormonal and biochemical parameters in the one-humped camel (Camelus dromedarius). Theriogenology, 86(3), 894-898.
• Hussain SO, Zaid NW, 2010: Dystocia in goats, causes and treatment. QJVMS, 9(1), 63-68.
• Hydbring E, Madej A, MacDonald E, Drugge-Boholm G, Berglund B, Olsson K, 1999: Hormonal changes during parturition in heifers and goats are related to the phases and severity of labour. J Endocrinol, 160 (1), 75-86.
• Jacobson C, Bruce M, Kenyon PR, Lockwood A, Miller D, Refshauge G, Masters DG, 2020: A review of dystocia in sheep. Small Rumin Res, 106209.
• Khan S, Satheesh A, Sabarinadh VR, Ranjith Mohan M, Sidhique SA, Panikkassery S, 2018: Surgical management of dystocia due to uterine adhesion in a goat. J Entomol Zool Studies, 6 (6), 988-991.
• Khanum SA, Hussain M, Kausar R, 2008: Progesterone and estradiol profiles during estrous cycle and gestation in Dwarf goats (Capra hircus). Pak Vet J, 28 (1), 1.
• Kurt S, Eşki F, Salar S, Sel T, Baştan A, 2021: The effect of heat stress on total oxidant capacity in hair goats. Vet Hekim Der Derg, 92 (1), 24-30.
• Manat TD, Chaudhary SS, Singh VK, Patel SB, Tyagi KK, 2017: Oxidative stress profile during postpartum period in Surti goats. Indian J Anim Res, 51 (5), 837-840.
• Nakao T, Grunert E, 1990: Effects of dystocia on postpartum adrenocortical function in dairy cows. J dairy sci, 73 (10), 2801-2806.
• Sathya A, Prabhakar S, Sangha SPS, Ghuman SPS, 2007: Vitamin E and selenium supplementation reduces plasma cortisol and oxidative stress in dystocia-affected buffaloes. Vet Res Commun, 31 (2007), 809–818.
• Singh AK, Bansal AK, Prabhakar S, Cheema RS, Singh P, Brar PS, Gandotra VK, 2011: Level of cortisol in placental tissue vis-à-vis oxidative stress in dystocia affected buffaloes. Indian J Anim Sci, 81 (3), 235-237.
• Thangamani A, Prasad BC, Srinivas M, Rao KS, 2019: Evaluation of oxidative stress in maternal dystocia affected cows (Bos indicus): A preliminary study. J Pharm Innov, 8 (5), 399-402.
• Nagel C, Aurich C, Aurich J, 2019: Stress effects on the regulation of parturition in different domestic animal species. Anim reprod sci, 207 (2019), 153-161.
• Zhang WC, Nakao T, Moriyoshi M, Nakada K, Ribadu AY, Ohtaki T, Tanaka Y, 1999: Relationship of maternal plasma progesterone and estrone sulfate to dystocia in Holstein-Friesian heifers and cows. J vet sci, 61(8), 909-913.